Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christian L Boutwell"'
Autor:
Matthew R Henn, Christian L Boutwell, Patrick Charlebois, Niall J Lennon, Karen A Power, Alexander R Macalalad, Aaron M Berlin, Christine M Malboeuf, Elizabeth M Ryan, Sante Gnerre, Michael C Zody, Rachel L Erlich, Lisa M Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L Axten, Adrianne D Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F Günthard, Zabrina L Brumme, Chanson J Brumme, Suzane Bazner, Jenna Rychert, Jake P Tinsley, Ken H Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z Levin, Sarah K Young, Heiko Jessen, Marcus Altfeld, Bruce W Birren, Bruce D Walker, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 8, Iss 3, p e1002529 (2012)
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-thro
Externí odkaz:
https://doaj.org/article/7846f6a69b894bfaae962b545cdfe22c
Autor:
Alexander R Macalalad, Michael C Zody, Patrick Charlebois, Niall J Lennon, Ruchi M Newman, Christine M Malboeuf, Elizabeth M Ryan, Christian L Boutwell, Karen A Power, Doug E Brackney, Kendra N Pesko, Joshua Z Levin, Gregory D Ebel, Todd M Allen, Bruce W Birren, Matthew R Henn
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002417 (2012)
Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including compre
Externí odkaz:
https://doaj.org/article/d0f6528648654fda9f716991047631fb
Autor:
Wilfredo F. Garcia-Beltran, Daniel T. Claiborne, Colby R. Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall E. Karpel, Katharine L. Krupp, Karen A. Power, Christian L. Boutwell, Alejandro B. Balazs, Andrew M. Tager, Marcus Altfeld, Todd M. Allen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Humanized bone marrow-liver-thymus (HuBLT) mice are a revolutionary small-animal model that has facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice recapitul
Externí odkaz:
https://doaj.org/article/e6c1b3fbd7f14cf4a30a0e8d524ed2d0
Autor:
Alejandro B. Balazs, Marshall Karpel, Daniel T. Claiborne, Colby R. Maldini, Andrew M. Tager, Christian L. Boutwell, Katharine Krupp, Meredith Phelps, Todd M. Allen, Karen A. Power, Vladimir Vrbanac, Wilfredo F. Garcia-Beltran, Marcus Altfeld
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Humanized bone marrow-liver-thymus (HuBLT) mice have facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice not only support robust HIV-1 infection, but also un
Autor:
Daniel T. Claiborne, Christian L. Boutwell, Timothy Bateson, Meredith Phelps, Radiana Trifonova, James A. Hoxie, Tao Chen, Derrick L. Dopkin, Karen A. Power, Colby R. Maldini, Ken Okawa, George J. Leslie, Xiaochuan Shan, Vladimir Vrbanac, Todd M. Allen, Katharine Krupp, James L. Riley, Serah Tanno
Publikováno v:
Nat Med
An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing the CD4 ectodomain to confer specificity for the HIV envelope,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e502a9bb70766c6db89848aaf0b33a
https://europepmc.org/articles/PMC9422086/
https://europepmc.org/articles/PMC9422086/
Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia
Autor:
Daniel T. Claiborne, Katharine Krupp, Todd M. Allen, Edward Seung, Elizabeth F. Mellors, Karen A. Power, Timothy Dudek, Vladimir Vrbanac, David M. Knipe, Christian L. Boutwell, Andrew M. Tager, Musie Ghebremichael, Abigail Bisesi, Colby R. Maldini
Publikováno v:
Journal of virology. 93(20)
BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional human immune system, develop prototypic human virus-specific CD8(+) T cell responses following infection with human immunodeficiency virus type 1 (HIV-1). We explored the
Publikováno v:
Current Opinion in Virology. 13:75-80
Humanized mice are valuable models for the research and development of vaccine strategies and therapeutic interventions to control or eradicate HIV. The BLT humanized mouse model is particularly promising because the combination of transplantation of
Publikováno v:
Journal of Virology. 83:2460-2468
Cytotoxic-T-lymphocyte (CTL) escape mutations in human immunodeficiency viruses encode amino acid substitutions in positions that disrupt CTL targeting, thereby increasing virus survival and conferring a relative fitness benefit. However, it is now c
Publikováno v:
Journal of Virological Methods. 149:69-75
In recent years, highly sensitive assays have been developed that detect HIV-1 drug resistance mutations when present at less than 1% of the viral population. These assays are powerful tools when attempting to determine the clinical implications of t
Publikováno v:
Canadian Journal of Zoology. 83:1614-1623
Genotype–phenotype–environment interactions in temperate-zone species of Colias Fabricius, 1807 have been well studied in evolutionary terms. Arctic and alpine habitats present a different range of ecological, especially thermal, conditions under