Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Christian Kukat"'
Autor:
Nikolai Tschernoster, Florian Erger, Stefan Kohl, Björn Reusch, Andrea Wenzel, Stephen Walsh, Holger Thiele, Christian Becker, Marek Franitza, Malte P. Bartram, Martin Kömhoff, Lena Schumacher, Christian Kukat, Tatiana Borodina, Claudia Quedenau, Peter Nürnberg, Markus M Rinschen, Jan H. Driller, Bjørn P. Pedersen, Karl P. Schlingmann, Bruno Hüttel, Detlef Bockenhauer, Bodo Beck, Janine Altmüller
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Long-read sequencing is increasingly used to uncover structural variants in the human genome, both functionally neutral and deleterious. Structural variants occur more frequently in regions with a high homology or repetitive segme
Externí odkaz:
https://doaj.org/article/562f2d8f33f64894b552c46d64c66672
Autor:
Christian Vossen, Patricia Schmidt, Claudia Maria Wunderlich, Melanie Joyce Mittenbühler, Claas Tapken, Peter Wienand, Paul Nicolas Mirabella, Leonie Cabot, Anna-Lena Schumacher, Kat Folz-Donahue, Christian Kukat, Ingo Voigt, Jens C. Brüning, Henning Fenselau, F. Thomas Wunderlich
Publikováno v:
Cells, Vol 13, Iss 1, p 102 (2024)
Enteroendocrine cells (EECs) constitute only a small proportion of Villin-1 (Vil1)-expressing intestinal epithelial cells (IECs) of the gastrointestinal tract; yet, in sum, they build the largest endocrine organ of the body, with each of them storing
Externí odkaz:
https://doaj.org/article/eaf10d02ed844a188e6cca6ae65c46b1
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D. Simons, Hisham Bazzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
How the developing skin epidermis is transformed from a simple single-layered epithelium to a complex and stratified barrier is still an open question. Here, the authors provide a model based on high proliferation and delamination of the keratinocyte
Externí odkaz:
https://doaj.org/article/a8d8b4dfc80449d585d4094cbc088097
Autor:
José A. Campoy, Hequan Sun, Manish Goel, Wen-Biao Jiao, Kat Folz-Donahue, Nan Wang, Manuel Rubio, Chang Liu, Christian Kukat, David Ruiz, Bruno Huettel, Korbinian Schneeberger
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-20 (2020)
Abstract Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whol
Externí odkaz:
https://doaj.org/article/658db518181749c3aa95c68557d4af5e
Autor:
Franziska M. Collmann, Rory Pijnenburg, Somayyeh Hamzei-Taj, Anuka Minassian, Kat Folz-Donahue, Christian Kukat, Markus Aswendt, Mathias Hoehn
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Microglia are the brain-innate immune cells which actively surveil their environment and mediate multiple aspects of neuroinflammation, due to their ability to acquire diverse activation states and phenotypes. Simplified, M1-like microglia are define
Externí odkaz:
https://doaj.org/article/f59de61bd6b24239be4f4bf9dd6a8b07
Autor:
Stefanie Vogel, Cordula Schäfer, Simon Hess, Kat Folz-Donahue, Melanie Nelles, Anuka Minassian, Martin K. Schwarz, Christian Kukat, Marc Ehrlich, Holm Zaehres, Peter Kloppenburg, Mathias Hoehn, Markus Aswendt
Publikováno v:
Stem Cell Research, Vol 37, Iss , Pp - (2019)
Understanding the individual timeline of stem cell differentiation in vivo is critical for evaluating stem cell properties in animal models. However, with conventional ex vivo techniques, such as histology, the individual timeline of differentiation
Externí odkaz:
https://doaj.org/article/d313a883cfd444bbba445c68fee2ccaf
Autor:
Marie Lagouge, Arnaud Mourier, Hyun Ju Lee, Henrik Spåhr, Timothy Wai, Christian Kukat, Eduardo Silva Ramos, Elisa Motori, Jakob D Busch, Stefan Siira, German Mouse Clinic Consortium, Elisabeth Kremmer, Aleksandra Filipovska, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005423 (2015)
We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on
Externí odkaz:
https://doaj.org/article/e1bf9ab72edd4e89b4da90f991133906
Autor:
Anna Wredenberg, Marie Lagouge, Ana Bratic, Metodi D Metodiev, Henrik Spåhr, Arnaud Mourier, Christoph Freyer, Benedetta Ruzzenente, Luke Tain, Sebastian Grönke, Francesca Baggio, Christian Kukat, Elisabeth Kremmer, Rolf Wibom, Paola Loguercio Polosa, Bianca Habermann, Linda Partridge, Chan Bae Park, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003178 (2013)
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial t
Externí odkaz:
https://doaj.org/article/552ff24687c845449ceccce47f040473
Autor:
Ana Bratic, Anna Wredenberg, Sebastian Grönke, James B Stewart, Arnaud Mourier, Benedetta Ruzzenente, Christian Kukat, Rolf Wibom, Bianca Habermann, Linda Partridge, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002324 (2011)
The bicoid stability factor (BSF) of Drosophila melanogaster has been reported to be present in the cytoplasm, where it stabilizes the maternally contributed bicoid mRNA and binds mRNAs expressed from early zygotic genes. BSF may also have other role
Externí odkaz:
https://doaj.org/article/e11fce0f497a42daba5830fd457069a4