Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christian Kozany"'
Autor:
Anne-Katrin Fabian, Andreas März, Sonja Neimanis, Ricardo M Biondi, Christian Kozany, Felix Hausch
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57508 (2013)
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase
Externí odkaz:
https://doaj.org/article/6ced5f649c81470a8c0a399ccadf0b7e
Autor:
Holger Prokisch, Curt Scharfe, David G Camp, Wenzhong Xiao, Lior David, Christophe Andreoli, Matthew E Monroe, Ronald J Moore, Marina A Gritsenko, Christian Kozany, Kim K Hixson, Heather M Mottaz, Hans Zischka, Marius Ueffing, Zelek S Herman, Ronald W Davis, Thomas Meitinger, Peter J Oefner, Richard D Smith, Lars M Steinmetz
Publikováno v:
PLoS Biology, Vol 2, Iss 6, p e160 (2004)
In this study yeast mitochondria were used as a model system to apply, evaluate, and integrate different genomic approaches to define the proteins of an organelle. Liquid chromatography mass spectrometry applied to purified mitochondria identified 54
Externí odkaz:
https://doaj.org/article/25c00d4e3c8142d496a874910156ef45
Autor:
Lee Freiburger, Marcelo Paez-Pereda, Günter K. Stalla, Michael Buchfelder, Felix Hausch, Christian Kozany, Michael Sattler, Mathias Riebold
Publikováno v:
Nature Medicine. 21:276-280
One function of the glucocorticoid receptor (GR) in corticotroph cells is to suppress the transcription of the gene encoding proopiomelanocortin (POMC), the precursor of the stress hormone adrenocorticotropin (ACTH). Cushing disease is a neuroendocri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bce96d7c9658050889c62b731836c5
https://doi.org/10.1038/nm.3776
https://doi.org/10.1038/nm.3776
Autor:
Paula Fernandez-Vizarra, Gerd Ruhter, Serena Cuboni, Mathias V. Schmidt, S. Gaali, Alexander Kirschner, Felix Hausch, Georgia Balsevich, Elisabeth B. Binder, Anthony S. Zannas, Andreas Bracher, Christian Namendorf, Chadi Touma, Christian Kozany, Rika Draenert, Osborne F. X. Almeida, Manfred Uhr, Jakob Hartmann, Claudia Sippel
Publikováno v:
Nature Chemical Biology. 11:33-37
The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. Drug discovery for FKBP51 has been hampered by the inability to pharmacologically differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8f83ab1f89a82c7102536a7a797395
https://doi.org/10.1038/nchembio.1699
https://doi.org/10.1038/nchembio.1699
Autor:
Felix Hausch, Y. Wang, Andreas Bracher, Sebastian Pomplun, Christian Kozany, Alexander Kirschner
Publikováno v:
Angewandte Chemie. 127:352-355
Um hochst effiziente Inhibitoren fur FK506-bindende Proteine zu erzielen, wurde eine neue asymmetrische Synthese fur pro-(S)-C5-verzweigte [4.3.1]-Aza-Amid-Bicyclen entwickelt. Der entscheidende Syntheseschritt war dabei eine HF-vermittelte N-Acylimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c92cab1d100dd06cc8229a34a145ef
https://doi.org/10.1002/ange.201408776
https://doi.org/10.1002/ange.201408776
Autor:
Andreas Hähle, Christian Kozany, Philipp Wild, Felix Hausch, Martin Zacharias, Andreas Bracher
Publikováno v:
Journal of Molecular Biology. 425:4134-4144
The human Hsp90 co-chaperone FKBP52 belongs to the family of FK506-binding proteins, which act as peptidyl-prolyl isomerases. FKBP52 specifically enhances the signaling of steroid hormone receptors, modulates ion channels and regulates neuronal outgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e1b72be37377069212e30de3dd02bb
https://doi.org/10.1016/j.jmb.2013.07.041
https://doi.org/10.1016/j.jmb.2013.07.041
Publikováno v:
Molecular and Cellular Biology. 33:1357-1367
The immunosuppressant and anticancer drug rapamycin works by inducing inhibitory protein complexes with the kinase mTOR, an important regulator of growth and proliferation. The obligatory accessory partner of rapamycin is believed to be FK506-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257bfb6d522d659a5adb514770eb0add
https://doi.org/10.1128/mcb.00678-12
https://doi.org/10.1128/mcb.00678-12
Autor:
S. Gaali, Felix Hausch, C. Kress, Christian Kozany, B. Hoogeland, Andreas Bracher, R. Gopalakrishnan
Publikováno v:
Journal of Medicinal Chemistry. 55:4114-4122
The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc50c364f9e960ba3d22c4f118163f4
https://doi.org/10.1021/jm201746x
https://doi.org/10.1021/jm201746x
Publikováno v:
Current Medicinal Chemistry. 18:5355-5379
The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f643be83dfd8a503db70e19e8947db1
https://doi.org/10.2174/092986711798194342
https://doi.org/10.2174/092986711798194342
Publikováno v:
ChemBioChem. 10:1402-1410
Talented all-rounders: Fluorescence polarisation assays were developed for members of the FK506-binding protein family by using fluorescent rapamycin analogues (demonstrated in the figure). These tracers retain medium to high affinity to all tested p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17475c46c759e5243e7388ca2ebb2d6d
https://doi.org/10.1002/cbic.200800806
https://doi.org/10.1002/cbic.200800806