Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Autor: Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka, the DELCODE study group

Publikováno v: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2023)

Abstract Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neu

Externí odkaz: https://doaj.org/article/cc42b75361934fa681bb00e0c1d00ff6

Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils

Autor: Tatjana Reif, Gerhard Dyckhoff, Ralph Hohenberger, Carl-Christian Kolbe, Henning Gruell, Florian Klein, Eicke Latz, Bettina Stolp, Oliver T. Fackler

Publikováno v: Cell Reports Medicine, Vol 2, Iss 6, Pp 100317- (2021)

Summary: Polymorphonuclear neutrophils (PMNs), the most abundant white blood cells, are recruited rapidly to sites of infection to exert potent anti-microbial activity. Information regarding their role in infection with human immunodeficiency virus (

Externí odkaz: https://doaj.org/article/2411acf8c3fd4a5ab6301faf1c2701f9

Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid‐binding protein 3 and ferritin to neurodegeneration and neuroinflammation

Autor: Frank Jessen, Carl-Christian Kolbe, Sergio Castro-Gomez, Pawel Tacik, Kilian Kleemann, Eicke Latz, Francesco Santarelli, Frederic Brosseron, Michael T. Heneka

Publikováno v: Journal of neurochemistry 157(6), 2210-2224 (2021). doi:10.1111/jnc.15175

There is growing evidence that promising biomarkers of inflammation in Alzheimer´s disease (AD) and other neurodegenerative diseases correlate strongest to levels of tau or neurofilament, indicating an inflammatory response to neuronal damage or dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669f6412a8a900d4d3fcf5b53bb82dc
https://doi.org/10.1111/jnc.15175

Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease

Autor: Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Pablo García González, Róisín M. McManus, Christina Ising, Francesco Santarelli, Carl-Christian Kolbe, Lisa M. Häsler, Steffen Wolfsgruber, Marta Marquié, Mercè Boada, Adelina Orellana, Itziar de Rojas, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Arda Cetindag, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Bürger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupov, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Charlotte E. Teunissen, Natalie L. Marchant, Annika Spottke, Mathias Jucker, Eicke Latz, Michael Wagner, David Mengel, Matthis Synofzik, Frank Jessen, Alfredo Ramirez, Agustín Ruiz, Michael T. Heneka

Publikováno v: the DELCODE study group 2022, ' Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease ', Neuron, vol. 110, no. 6, pp. 1009-1022.e4 . https://doi.org/10.1016/j.neuron.2021.12.016
Neuron, 110(6), 1009-1022.e4. Cell Press
Neuron 110(6), 1009-1022.e4 (2022). doi:10.1016/j.neuron.2021.12.016

There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD). We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41ef513202d55323e4fa7d6c6fae0e9
https://research.vumc.nl/en/publications/7b3bd725-fd82-4214-85cb-1b6558b53b1c

Contact-dependent inhibition of HIV-1 replication in

Autor: Tatjana, Reif, Gerhard, Dyckhoff, Ralph, Hohenberger, Carl-Christian, Kolbe, Henning, Gruell, Florian, Klein, Eicke, Latz, Bettina, Stolp, Oliver T, Fackler

Publikováno v: Cell Reports Medicine

Summary Polymorphonuclear neutrophils (PMNs), the most abundant white blood cells, are recruited rapidly to sites of infection to exert potent anti-microbial activity. Information regarding their role in infection with human immunodeficiency virus (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15af39cf428f7dfc7a715f3f58e0e657
https://pubmed.ncbi.nlm.nih.gov/34195682