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Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine
Autor:
Wilcox Glenn Ernest, Weiling Cai, Mark Edward Flanagan, Stefan Abele, Jeffrey M. Casavant, Mike Munchhoff, David H. Brown Ripin, Ton Vries, David A. Whipple, Kees Pouwer, Cliff Meltz, Jianmin Sun, Keith E. McCarthy, Klaus Laue, John J. Teixeira, Christian Koecher, Jonathan L. Doty, Bharat Kiritkumar Shah, Todd Andrew Blumenkopf
Publikováno v:
Organic Process Research & Development. 7:115-120
The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4c02f223cd1ebe05d57ff7969d746b
https://doi.org/10.1021/op025599x
https://doi.org/10.1021/op025599x
