Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christian Kappe"'
Autor:
Marcel Rühling, Louise Kersting, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, Dominic A. Helmerich, Tom Pfeuffer, Robin Elflein, Christian Kappe, Markus Sauer, Christoph Arenz, Burkhard Kleuser, Thomas Rudel, Martin Fraunholz, Jürgen Seibel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Sphingomyelin is a key molecule of sphingolipid metabolism, and its enzymatic breakdown is associated with various infectious diseases. Here, we introduce trifunctional sphingomyelin derivatives that enable the visualization of sphingomyelin
Externí odkaz:
https://doaj.org/article/49744d45d0a244ae925aa7fb11b17b6c
Autor:
Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific AS
Externí odkaz:
https://doaj.org/article/5e9c3b6587c9418bb93a4e4217043165
Autor:
Gita Naseri, Kevin Prause, Fabian Schumacher, Burkhard Kleuser, Christoph Arenz, Christian Kappe
Publikováno v:
Chemical communications (Cambridge, England). 56(94)
Acid sphingomyelinase (ASM) is a potential drug target and involved in rapid lipid signalling events. However, there are no tools available to adequately study such processes. Based on a non cell-permeable PtdIns(3,5)P2 inhibitor of ASM, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b64e9fc80ab287caed2f7660c9d4f6
https://pubmed.ncbi.nlm.nih.gov/33179626
https://pubmed.ncbi.nlm.nih.gov/33179626
Autor:
Burkhard Kleuser, Eyad Naser, Christian Kappe, Barbara Pollmeier, Fabian Schumacher, Gabriele Hessler, Katrin Anne Becker, Alexander Carpinteiro, Zainelabdeen H. Mohamed, Stephanie Kadow, Erich Gulbins, Christoph Arenz
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific AS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b708e5c93c220fcbed28ab2e1d9ba8
https://pubmed.ncbi.nlm.nih.gov/32156719
https://pubmed.ncbi.nlm.nih.gov/32156719
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Activity of acid sphingomyelinase has been implicated in a number of diseases like acute lung injury, sepsis or metastasis of melanoma cells. Here, we present a sphingomyelinase FRET probe based on FAM/BODIPY dyes for real‐time monitoring of acid s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a35eb1b1e2dd3190959624dc975def
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85083650561
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85083650561
Autor:
Christian Kappel, Thomas Friedrich, Vicky Oberkofler, Li Jiang, Tim Crawford, Michael Lenhard, Isabel Bäurle
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Transcriptional regulation is a key aspect of environmental stress responses. Heat stress induces transcriptional memory, i.e., sustained induction or enhanced re-induction of transcription, that allows plants to respond more effi
Externí odkaz:
https://doaj.org/article/d6008cea18a349eab159c830dd9b89ea
Publikováno v:
Ecology and Evolution, Vol 11, Iss 20, Pp 13986-14002 (2021)
Abstract To predict how widely distributed species will perform under future climate change, it is crucial to understand and reveal their underlying phylogenetics. However, detailed information about plant adaptation and its genetic basis and history
Externí odkaz:
https://doaj.org/article/8266d597c652405ea78110162f60811f
Autor:
Thomas Friedrich, Vicky Oberkofler, Inês Trindade, Simone Altmann, Krzysztof Brzezinka, Jörn Lämke, Michal Gorka, Christian Kappel, Ewelina Sokolowska, Aleksandra Skirycz, Alexander Graf, Isabel Bäurle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Moderate heat stress primes plants to acquire tolerance to subsequent, more severe heat stress. Here the authors show that the HSFA3 transcription factor forms a heteromeric complex with HSFA2 to sustain activated transcription of genes required for
Externí odkaz:
https://doaj.org/article/6a061bceb9b648abac5d790a57a81371
Autor:
Christian Kappe
Publikováno v:
Cell and tissue research. 274(2)
Light- and electron-microscopical observations revealed a rod-like inclusion body in the pinealocytes of the common spiny mouse (Acomys cahirinus dimidiatus). Ultrastructurally, the body is composed of a varying number of tubes whose wall consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af8aebaa8d51edda9a55e6a4f8b35b4
https://pubmed.ncbi.nlm.nih.gov/8269483
https://pubmed.ncbi.nlm.nih.gov/8269483
Publikováno v:
Plant Methods, Vol 15, Iss 1, Pp 1-14 (2019)
Abstract Background The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCR-genotyping indivi
Externí odkaz:
https://doaj.org/article/0709569009404202a7d2942110c37966