Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christian K. Nickl"'
Autor:
Huining Kang, Nitesh D. Sharma, Christian K. Nickl, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter, Ksenia Matlawska-Wasowska
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-6 (2018)
Abstract For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is
Externí odkaz:
https://doaj.org/article/55340d08b2874ebba7679ef33ff128e6
Autor:
Hunter Bennett, Ty D. Troutman, Enchen Zhou, Nathanael J. Spann, Verena M. Link, Jason S. Seidman, Christian K. Nickl, Yohei Abe, Mashito Sakai, Martina P. Pasillas, Justin M. Marlman, Carlos Guzman, Mojgan Hosseini, Bernd Schnabl, Christopher K. Glass
Noncoding genetic variation is a major driver of phenotypic diversity but determining the underlying mechanisms and the cell types in which it acts remain challenging problems. Here, we investigate the impact of natural genetic variation provided by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e1ba62532f56fe28a35a9ca423c9e2
https://doi.org/10.1101/2022.09.22.509046
https://doi.org/10.1101/2022.09.22.509046
Autor:
Ksenia Matlawska-Wasowska, Wojciech Ornatowski, Huining Kang, Charles G. Mullighan, Roger B. Brown, Scott A. Ness, Mignon L. Loh, Stephen P. Hunger, Judy L. Cannon, Christian K. Nickl, Stuart S. Winter, Nitesh D. Sharma
Publikováno v:
Cancer Science. 110:1931-1946
Activating mutations in cytokine receptors and transcriptional regulators govern aberrant signal transduction in T-cell lineage acute lymphoblastic leukemia (T-ALL). However, the roles played by suppressors of cytokine signaling remain incompletely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ea6fa1d46b5baaf2c3aafe11a24cb1c
https://doi.org/10.1111/cas.14021
https://doi.org/10.1111/cas.14021
Autor:
Barbara De Moerloose, Serge Van Calenbergh, Wojciech Ornatowski, Steven Goossens, Sofie Peirs, Alexandre Chigaev, Wouter Van Loocke, Charles G. Mullighan, Pieter Van Vlierberghe, Christian K. Nickl, Takeshi Takarada, Mignon L. Loh, Eliseo F. Castillo, Laurence C. Cheung, Dominique Perez, Béatrice Lintermans, Yukio Yoneda, Frederik W. van Delft, Richard B. Lock, Stuart S. Winter, Juliette Roels, Stephen P. Hunger, Lisa Demoen, Lindy Reunes, Ksenia Matlawska-Wasowska, Larry A. Sklar, Monique Nysus, Rishi S. Kotecha, Tim Lammens, Huining Kang, Dieter Deforce, Tim Pieters, Nitesh D. Sharma, Filip Van Nieuwerburgh, Martijn D. P. Risseeuw, Seth D. Merkley, Filip Matthijssens
Publikováno v:
J Clin Invest
JOURNAL OF CLINICAL INVESTIGATION
JOURNAL OF CLINICAL INVESTIGATION
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7320b73d3d90f1b61255b31a6ace270f
https://europepmc.org/articles/PMC7954605/
https://europepmc.org/articles/PMC7954605/
Autor:
Jiayang Xiao, Zahara Keulen, Fred H. Gage, Christopher K. Glass, Martina P. Pasillas, Carolyn O’Connor, James B. Brewer, Simon T. Schafer, Monique Pena, Miao Yu, Johannes C. M. Schlachetzki, David Gosselin, Christian K. Nickl, Inge R. Holtman, Michael G. Rosenfeld, Graham McVicker, Nicole G. Coufal, Alexi Nott, Rong Hu, Claudia Z. Han, David D. Gonda, Robert A. Rissman, Michael J. Levy, Zeyang Shen, Yin Wu, Bing Ren
Publikováno v:
Science, 366(6469), 1134-1139. AMER ASSOC ADVANCEMENT SCIENCE
Science (New York, N.Y.), vol 366, iss 6469
Science (New York, N.Y.), vol 366, iss 6469
Linking enhancers to disease Enhancers are genomic regions that regulate gene expression, sometimes in a cell-dependent manner. However, most of our knowledge of human brain cell–type enhancers derives from studies of bulk human brain tissue. Nott
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01603c06f7b8071ef8ceeda537b0e23b
https://research.rug.nl/en/publications/f04a1391-702e-4b5b-ac43-73946846b535
https://research.rug.nl/en/publications/f04a1391-702e-4b5b-ac43-73946846b535
Autor:
Elizabeth A. Raetz, Brent L. Wood, Stuart S. Winter, Christian K. Nickl, Scott A. Ness, Carmen Martinez, William L. Carroll, Meenakshi Devidas, Yongjin Li, Jinghui Zhang, Richard C. Harvey, Barbara L. Asselin, Richard S. Larson, André Baruchel, Hervé Dombret, Jean Soulier, I-Ming Chen, Charles G. Mullighan, Masahiro Onozawa, Andrew J. Carroll, Mignon L. Loh, Nyla A. Heerema, Kathryn G. Roberts, Naomi J. Winick, Stephen P. Hunger, Kimberly P. Dunsmore, Michael Rusch, Ji Wen, Huining Kang, Peter D. Aplan, Ksenia Matlawska-Wasowska
Publikováno v:
Leukemia
MLL rearrangements impact outcome in HOXA -deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1fd6101404dd4a392cffd60ee9258a
http://europepmc.org/articles/PMC5014577
http://europepmc.org/articles/PMC5014577
Autor:
Mignon L. Loh, Stephen P. Hunger, Huining Kang, Christian K. Nickl, Ksenia Matlawska-Wasowska, Kimberly P. Dunsmore, Meenakshi Devidas, Nitesh D. Sharma, Stuart S. Winter
Publikováno v:
Biomarker research, vol 6, iss 1
Biomarker Research, Vol 6, Iss 1, Pp 1-6 (2018)
Biomarker Research, Vol 6, Iss 1, Pp 1-6 (2018)
For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138d6cdb34a3de42abca02148b5b7b1f
https://doi.org/10.1186/s40364-018-0141-z
https://doi.org/10.1186/s40364-018-0141-z
Autor:
Dominique Perez, Stephen P. Hunger, Alexandre Chigaev, Michelle L. Hermiston, Cristina Delgado-Martin, Travis A. Woods, Bruce S. Edwards, Ksenia Matlawska-Wasowska, Anna Waller, Nitesh D. Sharma, Stuart S. Winter, Mignon L. Loh, Larry A. Sklar, Christian K. Nickl
Publikováno v:
SLAS discovery : advancing life sciences R & D, vol 23, iss 7
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with T-cell lineage acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d09a3fbd8cba1c062b5dc9a71ba3c1
https://europepmc.org/articles/PMC6292518/
https://europepmc.org/articles/PMC6292518/
Autor:
Gavin Pickett, James M. Gale, Stuart S. Winter, Jodi R. Mayfield, David R. Czuchlewski, Christian K. Nickl, Mohammad A. Vasef, Scott A. Ness, Ksenia Matlawska-Wasowska
Publikováno v:
Pediatric bloodcancer. 64(5)
A 17-year-old girl with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with persistent minimal residual disease (MRD) who underwent standard chemotherapy was found to have a BCR-ABL1-like gene expression pattern. Genome sequencing revealed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fa237faf2840771d9ddb8e1958ca09
https://pubmed.ncbi.nlm.nih.gov/27860260
https://pubmed.ncbi.nlm.nih.gov/27860260
Autor:
Bryan A. Ballif, Alan K. Howe, Paula B. Deming, Wolfgang R. Dostmann, George B. Caldwell, Christian K. Nickl
Publikováno v:
Journal of Cellular Biochemistry. 113:39-48
Protein kinases are enzymes that transmit signals throughout the intracellular environment. They catalyze the transfer of a phosphate group from ATP to serine, threonine and tyrosine residues within downstream substrates and in this manner alter the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40babac64f8ebb2ce6b70216e8bf8d1c
https://doi.org/10.1002/jcb.23325
https://doi.org/10.1002/jcb.23325