Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christian K Engel"'
Publikováno v:
Drug Development Research. 81:329-337
Monoclonal antibodies (mAbs) are currently leading products in the global biopharmaceutical market. Multiple mAbs are in clinical development and novel biotherapeutic protein scaffolds, based on the canonical immunoglobulin G (IgG) fold, are emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e3b52ba347cd9f1b20fc56638d487b
https://doi.org/10.1002/ddr.21624
https://doi.org/10.1002/ddr.21624
Autor:
Carolin, Gerbeth-Kreul, Antje, Pommereau, Sven, Ruf, John L, Kane, Theresa, Kuntzweiler, Gerhard, Hessler, Christian K, Engel, Patrick, Shum, LinLi, Wei, Joerg, Czech, Thomas, Licher
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(6)
Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9160baf68ccf7faf0016023ba5f4dc1
https://pubmed.ncbi.nlm.nih.gov/33955247
https://pubmed.ncbi.nlm.nih.gov/33955247
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1564(1):47-56
Protein stability, as measured by irreversible protein aggregation, is one of the central difficulties in the handling of detergent-solubilized membrane proteins. We present a quantitative analysis of the stability of the Escherichia coli lactose (la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62623c503b5f86db312af4c0d6f4bbd0
Autor:
Jenny C. Lee, H R Kaback, Gilbert G. Privé, J. le Coutre, Christian K Engel, Kym F. Faull, Julian P. Whitelegge
Publikováno v:
Proceedings of the National Academy of Sciences. 96:10695-10698
Genes encoding membrane proteins comprise a substantial proportion of genomes sequenced to date, but ability to perform structural studies on this portion of the proteome is limited. Electrospray ionization-MS (ESI-MS) of an intact protein generates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417a23ab7764fc21f0b669e0729a81c4
https://doi.org/10.1073/pnas.96.19.10695
https://doi.org/10.1073/pnas.96.19.10695
Publikováno v:
Proceedings of the National Academy of Sciences. 95:12123-12128
The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein–protein interaction motif found at the N terminus of 5–10% of C 2 H 2 -type zinc-finger transcription factors, as well as in some actin-associated proteins beari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2a44a069a0d5ef1d87e565092a0e4c
https://doi.org/10.1073/pnas.95.21.12123
https://doi.org/10.1073/pnas.95.21.12123
Autor:
Yorgo Modis, J. P. Zeelen, Christian K Engel, Bjarne Rasmussen, Anders Ahlberg, Ruben Abagyan, Rik K. Wierenga, Magali Mathieu, Victor S. Lamzin, Wolf H. Kunau
Publikováno v:
Journal of Molecular Biology. 273:714-728
The dimeric, peroxisomal 3-ketoacyl-CoA thiolase catalyses the conver- sion of 3-ketoacyl-CoA into acyl-CoA, which is shorter by two carbon atoms. This reaction is the last step of the b-oxidation pathway. The crys- tal structure of unliganded peroxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4de2f082602f2c63a3ca1763777a46
https://doi.org/10.1006/jmbi.1997.1331
https://doi.org/10.1006/jmbi.1997.1331
Autor:
Gilbert G. Privé, Eileen I. Lo, Peter M. Hwang, Russell E. Bishop, Lewis E. Kay, Victoria E. Ahn, Christian K Engel, Lu Chen
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any membrane-bound enzyme remains to be defined. PagP is an outer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a525c67a98c5fddae85cc6c931f2e9
https://europepmc.org/articles/PMC514935/
https://europepmc.org/articles/PMC514935/
Autor:
Rik K. Wierenga, Christian K Engel
Publikováno v:
Current opinion in structural biology. 6(6)
Coenzyme A is involved in a number of important metabolic pathways. Recently the structures of several coenzyme A binding proteins have been determined. We compare in some detail the structures of seven different coenzyme A protein complexes. These s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29281cf9030daeb6fb9cfa90f6caf076
https://pubmed.ncbi.nlm.nih.gov/8994879
https://pubmed.ncbi.nlm.nih.gov/8994879