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pro vyhledávání: '"Christian Jede"'
Autor:
Christian Jede, Laura J. Henze, Kirstin Meiners, Malte Bogdahn, Marcel Wedel, Valeria van Axel
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1069 (2023)
A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption i
Externí odkaz:
https://doaj.org/article/4138e665bcd04d85811abb763486677f
Autor:
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann, Katleen Hellemans, Christian Jede, Alexandros Kourentas, Maude Reggane, Lipa Shah, Christian Wagner, Maria Vertzoni, Christos Reppas
Publikováno v:
Journal of Pharmaceutical Sciences.
Autor:
James Mann, Andre Hermans, Nathan Contrella, Beverly Nickerson, Carrie A. Coutant, Christian Jede, Shangming Kao, Dawen Kou, Emmanuel Scheubel, Fredrik Winge, Johanna Milsmann, Martin Mueller-Zsigmondy, Nikolay Zaborenko
Publikováno v:
Dissolution Technologies. 29:190-203
Autor:
Andre, Hermans, Johanna, Milsmann, Hanlin, Li, Christian, Jede, Andrea, Moir, Bart, Hens, James, Morgado, Tian, Wu, Michael, Cohen
Publikováno v:
The AAPS Journal. 25
This manuscript represents the view of the Dissolution Working Group of the IQ Consortium on the challenges of and recommendations on solubility measurements and development of dissolution methods for immediate release (IR) solid oral dosage forms fo
Autor:
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann, Katleen Hellemans, Christian Jede, Alexandros Kourentas, Maude Reggane, Lipa Shah, Christian Wagner, Christos Reppas, Maria Vertzoni
Publikováno v:
International Journal of Pharmaceutics. 634:122670
Autor:
Christian Jede, Lassina Badolo, Christian Wagner, Christian Weber, Markus Weigandt, Mirko Koziolek, Holger Kubas, Werner Weitschies, Marc Lecomte
Publikováno v:
Molecular Pharmaceutics. 16:3938-3947
The characterization of intestinal dissolution of poorly soluble drugs represents a key task during the development of both new drug candidates and drug products. The bicarbonate buffer is considered as the most biorelevant buffer for simulating inte
Autor:
Christian Wagner, Christian Jede, Werner Weitschies, Christian Weber, Holger Kubas, Mirko Koziolek, Markus Weigandt
Publikováno v:
International Journal of Pharmaceutics. 565:458-471
The majority of NCEs are weakly basic drugs. Consequently, their solubility is highly pH-dependent, with higher solubility in the acidic stomach and poor solubility in the neutral intestinal environment. The gastric emptying of dissolved drug can lea
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1315-1323
Objectives Dissolution testing of poorly soluble and precipitating drugs is of great importance for pharmaceutical industry. As offline HPLC analytics is time-consuming and labour-intensive, the development of suitable in-line analytics to measure dr
Autor:
Markus Weigandt, Holger Kubas, Mirko Koziolek, Christian Jede, Christian Wagner, Werner Weitschies, Christian Weber
Publikováno v:
International journal of pharmaceutics. 556
Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug substance characterization during early development stages, where the amount of API available is limited. Therefore, it was the aim of this study to develop a
Publikováno v:
International Journal of Pharmaceutics. 574:118917
Formulation of amorphous solid dispersions (ASD) is one possibility to improve poor aqueous drug solubility by creating supersaturation. In case of weakly basic drugs like ketoconazole (KTZ), supersaturation can also be generated during the gastroint