Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christian J. Nievera"'
Publikováno v:
Journal of Biological Chemistry. 283:7713-7720
BRCA1 plays an important role in the homologous recombination (HR)-mediated DNA double-strand break (DSB) repair, but the mechanism is not clear. Here we describe that BRCA1 forms a complex with CtIP and MRN (Mre11/Rad50/Nbs1) in a cell cycle-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b9041e89ab9b120632e811f03403bf
https://doi.org/10.1074/jbc.m710245200
https://doi.org/10.1074/jbc.m710245200
Publikováno v:
Journal of Biological Chemistry. 282:22939-22952
The Mre11-Rad50-Nbs1 (MRN) complex is required for mediating the S-phase checkpoint following UV treatment, but the underlying mechanism is not clear. Here we demonstrate that at least two mechanisms are involved in regulating the S-phase checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315f0bfea83fe15c4dba6beaf871cc0f
https://doi.org/10.1074/jbc.m702162200
https://doi.org/10.1074/jbc.m702162200
Publikováno v:
Journal of Biological Chemistry. 281:39517-39533
Upon DNA damage, replication is inhibited by the S-phase checkpoint. ATR (ataxia telangiectasia mutated- and Rad3-related) is specifically involved in the inhibition of replicon initiation when cells are treated with DNA damage-inducing agents that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6eb8d87f35d0bdb843dfa5b1ce37f
https://doi.org/10.1074/jbc.m605121200
https://doi.org/10.1074/jbc.m605121200
The Mre11/Rad50/Nbs1 complex (MRN) plays an essential role in the S-phase checkpoint. Cells derived from patients with Nijmegen breakage syndrome and ataxia telangiectasia-like disorder undergo radioresistant DNA synthesis (RDS), failing to suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ed6f87265a3f7cc65d1c097f0e251e
https://europepmc.org/articles/PMC1952149/
https://europepmc.org/articles/PMC1952149/
Publikováno v:
Molecular microbiology. 46(1)
Pre-replication complexes (pre-RC) assemble on replication origins and unwind DNA in the presence of chromatin proteins. As components of Escherichia coli pre-RC, two histone-like proteins HU and IHF (integration host factor), stimulate initiator Dna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::120fb8a0179f05bd9ad29359dc1e9ac8
https://pubmed.ncbi.nlm.nih.gov/12366835
https://pubmed.ncbi.nlm.nih.gov/12366835