Výsledky vyhledávání - "Christian J. Lemmerhirt"

Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity

Autor: Kristin Beirow, Julia Jedamzik, Lukas Schulig, Konrad W. Wurm, Christian J. Lemmerhirt, Robert K. Hofstetter, Andreas Link, Patrick J. Bednarski

Publikováno v: ChemMedChem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e8a268eaeb445ef757b1d01a0fea24a
https://doi.org/10.1002/cmdc.202300145

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Oxidation Potentials of N-Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity

Autor: Anja Bodtke, Andreas Link, Christian J. Lemmerhirt, Patrick J. Bednarski, Mirko Rombach

Publikováno v: ChemMedChem. 10:368-379

Openers of neuronal voltage-gated potassium channels (KV ) are of interest as therapeutic agents for treating pain (flupirtine) and epilepsy (retigabine). In an effort to better understand the mechanisms of action and toxicity of flupirtine, we synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a1db43422724f869881e1c59a45bc7
https://doi.org/10.1002/cmdc.201402442

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