Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christian J Braun"'
Autor:
Adaobi Mofunanya, Eleanor R. Cameron, Christian J. Braun, Frank Celeste, Xiaoyu Zhao, Michael T. Hemann, Kenneth L. Scott, Jinyu Li, Scott Powers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract There are hundreds of genes typically overexpressed in breast cancer cells and it's often assumed that their overexpression contributes to cancer progression. However, the precise proportion of these overexpressed genes contributing to tumor
Externí odkaz:
https://doaj.org/article/2e94ab9f512a48898053bbf41470759c
Autor:
Natalya N Pavlova, Christian Pallasch, Andrew EH Elia, Christian J Braun, Thomas F Westbrook, Michael Hemann, Stephen J Elledge
Publikováno v:
eLife, Vol 2 (2013)
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. A gain of func
Externí odkaz:
https://doaj.org/article/35a1c62bb4604d2c8fecec3f358548ad
Autor:
Felix Orben, Katharina Lankes, Christian Schneeweis, Zonera Hassan, Hannah Jakubowsky, Lukas Krauß, Fabio Boniolo, Carolin Schneider, Arlett Schäfer, Janine Murr, Christoph Schlag, Bo Kong, Rupert Öllinger, Chengdong Wang, Georg Beyer, Ujjwal M. Mahajan, Yonggan Xue, Julia Mayerle, Roland M. Schmid, Bernhard Kuster, Roland Rad, Christian J. Braun, Matthias Wirth, Maximilian Reichert, Dieter Saur, Günter Schneider
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Systemic therapies for pancreatic ductal adenocarcinoma (PDAC) remain unsatisfactory. Clinical prognosis is particularly poor for tumor subtypes with activating aberrations in the MYC pathway, creating an urgent need for novel therapeutic targets. To
Externí odkaz:
https://doaj.org/article/eb693ba667cc4d5dae97e9b398a9f104
Publikováno v:
Nature Protocols. 17:1903-1925
Here we provide a detailed tutorial on CRISPR in vivo screening. Using the mouse as the model organism, we introduce a range of CRISPR tools and applications, delineate general considerations for 'transplantation-based' or 'direct in vivo' screening
Autor:
Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Christian J. Braun, Dieter Saur, Stefan Engelhardt, Roland Rad
Publikováno v:
Nature Protocols. 17:1142-1188
Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic stem cells. Here, we describe methods for rapid and scalable genome engineering in somatic cel
Autor:
K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke
Mutated in approximately 30% of human cancers, Ras GTPases are the most common drivers of oncogenesis and render tumors unresponsive to many standard therapies. Despite decades of research, no drugs directly targeting Ras are currently available. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eee4f01b70dca9119d86936d6043a5
https://doi.org/10.1158/1535-7163.c.6537837.v1
https://doi.org/10.1158/1535-7163.c.6537837.v1
Autor:
K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke
Supplementary Figure S1. Cell lines constitutively express R11.1.6 or control proteins YW1 and EGFP. a, Flow cytometry histograms of human cancer cell lines A431, HT-29, LS180, and HPAF-II, transduced to constitutively express EGFP, R11.1.6 (and an E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821b86b5e150248cb82275e07830ab9
https://doi.org/10.1158/1535-7163.22504734.v1
https://doi.org/10.1158/1535-7163.22504734.v1
Autor:
Leona D. Samson, Forest M. White, Michael T. Hemann, Jacqueline A. Lees, Natalia Tretyakova, Yimin Chen, Amanda Vargas, Kelly Barford, Edvinas Cerniauskas, Dewakar Sangaraju, Patrizia Mazzucato, Zachary D. Nagel, Monica Stanciu, Christian J. Braun, José L. McFaline-Figueroa
Supplementary Figures S1-S14. p53 levels in p53 knockdown GBM cells (S1); TMZR3 cells obtained from a p53 deficient background display increased ploidy (S2); H2AX activation in temozolomide treated parental and TMZR3 GBM cells (S3); In-cell Host cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d61595daab9ce727fba79788a9a5d5e
https://doi.org/10.1158/0008-5472.22405706.v1
https://doi.org/10.1158/0008-5472.22405706.v1
Autor:
Leona D. Samson, Forest M. White, Michael T. Hemann, Jacqueline A. Lees, Natalia Tretyakova, Yimin Chen, Amanda Vargas, Kelly Barford, Edvinas Cerniauskas, Dewakar Sangaraju, Patrizia Mazzucato, Zachary D. Nagel, Monica Stanciu, Christian J. Braun, José L. McFaline-Figueroa
Supplementary Tables S1-S2. O6-methylguanine adducts levels in parental and TMZR3 GBM cells 3 hours post-TMZ exposure (S1); shRNA constructs used in this study (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03141e6265910024dfffd4d88b95bfac
https://doi.org/10.1158/0008-5472.22405700.v1
https://doi.org/10.1158/0008-5472.22405700.v1
Autor:
Matthias Dobbelstein, Claus L. Andersen, Torben F. Ørntoft, Troels Schepeler, Ute M. Moll, Sonja Wolff, Irina Savelyeva, Xin Zhang, Christian J. Braun
Supplementary Figures 1-8 from p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06caca5d9cce6fd1bc7697b7eff951d2
https://doi.org/10.1158/0008-5472.22375875
https://doi.org/10.1158/0008-5472.22375875