Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christian Herhaus"'
Autor:
Christian Schmidl, Wolfgang Herr, Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Roberta Ferretti, Clarissa Korf, Lisa Schmidleithner, Benedikt Nerb, Carina Matos, Gudrun E Koehl, Peter Siska, Christina Bruss, Fabian Kellermeier, Katja Dettmer, Peter J Oefner, Marvin Wichland, Ines Ugele, Christopher Bohr, Shivapriya Ramaswamy, Timo Heinrich, Christian Herhaus, Marina Kreutz, Kathrin Renner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for th
Externí odkaz:
https://doaj.org/article/c03d167b710e4bcd97adb742f3e84064
Autor:
Andrzej Gondela, Marcin Leś, Maciej Mikulski, Łukasz Włoszczak, Frank Becker, Kamila Olech, Shivapriya Ramaswamy, Marcin Król, Henryk Pawlik, Christian Herhaus, Jose Alvarez, Joanna Szczęśniak, Heike Schilke, Paulina Niedziejko, Lindsey Crowley, Roberta Ferretti, Mireille Krier, Pamela Wahra, Pia Böpple, Timo Heinrich, Justyna Martyka, Ewa Sitek, Karol Zuchowicz, Ada Sala-Hojman, Anna Bartosik, Stefano Minguzzi, Łukasz Dudek, Frank Czauderna, Mateusz Nowak, Ansgar Wegener, Michal Galezowski, Carl Petersson, Sven Jäckel
Publikováno v:
Journal of medicinal chemistry. 64(16)
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d3f6d43a88e3759b7bf441af1e7dd6
https://pubmed.ncbi.nlm.nih.gov/34382802
https://pubmed.ncbi.nlm.nih.gov/34382802
Autor:
Oliver Pöschke, Christian Herhaus, Elissaveta Petrova, Laura Helming, Friedrich Rippmann, Jan-Carsten Pieck, Sandra Schäffner
Publikováno v:
Cancer Immunology Research. 7:A099-A099
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive function, which inhibit the antitumor activity of T-cells and natural killer (NK) cells. MDSC number is greatly increased in tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ac5fa783c0c9abe326aad9eb181b46
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a099
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a099
Autor:
Oliver Karch, Christian Herhaus
Publikováno v:
Nachrichten aus der Chemie. 57:1002-1004
Ein Medizinalchemiker muss mitunter viele strukturell verwandte Molekule untersuchen, um Substanzklassen fur Versuche zu identifizieren. Navigationskonzepte und Werkzeuge aus der Kartographie und der Geoinformatik konnen ihm helfen, sich im Raum chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f68af44dedf3db134b0c5638389aeff
https://doi.org/10.1002/nadc.200966732
https://doi.org/10.1002/nadc.200966732
Publikováno v:
Helvetica Chimica Acta. 80:1408-1420
Treatment of celery leaves (Apium graveolens, cv. secalinum) with Jasmonic acid (JA, 1) or analogues of amino-acid conjugates of Jasmonic acid such as the leucine conjugate with 1-oxoindan-4-carboxylic acid (IN-ILE, 2) stimulated the biosynthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ced3d97942374a668a8bc688ba081f9
https://doi.org/10.1002/hlca.19970800507
https://doi.org/10.1002/hlca.19970800507
Autor:
Christian Herhaus, Lars Neumann, Andreas Heine, Helene Köster, Sascha Brass, Tobias Craan, Matthias Zentgraf, Gerhard Klebe
Publikováno v:
Journal of medicinal chemistry. 54(22)
Druglike molecules are defined by Lipinski's rule of 5, to characterize fragment thresholds, they have been reduced from 5 to 3 (Astex's rule of 3). They are applied to assemble fragment libraries, and providers use them to select fragments for comme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953bc4b25e7d7ad227024ff8dfa48c41
https://pubmed.ncbi.nlm.nih.gov/21972967
https://pubmed.ncbi.nlm.nih.gov/21972967
Autor:
Clarissa Gerhäuser, Christian Herhaus, Elisabeth Bertl, Hans Becker, Helmut Bartsch, Theophil Eicher, Govind J. Kapadia
Publikováno v:
Biochemical and biophysical research communications. 325(1)
Endothelial cells (EC) play a major role in tumor-induced neovascularization and bridge the gap between a microtumor and growth factors such as nutrients and oxygen supply required for expansion. Immortalized human microvascular endothelial cells (HM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb2ecb8519abb3f431c23b8792d6650
https://pubmed.ncbi.nlm.nih.gov/15522231
https://pubmed.ncbi.nlm.nih.gov/15522231
Autor:
Christian Herhaus
Publikováno v:
Journal of Cheminformatics
Arranging similar structures in clusters is one of the typical tasks of modern Chemoinformatics with high impact in HTS follow-up, generation of structure activity relationships (SAR) and selection of starting points for compound optimisation. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5701b24e9f58490f95f7f50b5605c2d3
http://europepmc.org/articles/PMC3980174
http://europepmc.org/articles/PMC3980174
Publikováno v:
The Journal of biological chemistry. 276(34)
Sulforaphane (SFN), an aliphatic isothiocyanate, is a known cancer chemopreventive agent. Aiming to investigate anti-inflammatory mechanisms of SFN, we here report a potent decrease in lipopolysaccharide (LPS)-induced secretion of pro-inflammatory an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d0975a743165334e347e93b01fddbc
https://pubmed.ncbi.nlm.nih.gov/11410599
https://pubmed.ncbi.nlm.nih.gov/11410599
