Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christian Harak"'
Autor:
Cristina M. Dorobantu, Lucian Albulescu, Heyrhyoung Lyoo, Mirjam van Kampen, Raffaele De Francesco, Volker Lohmann, Christian Harak, Hilde M. van der Schaar, Jeroen R. P. M. Strating, Alexander E. Gorbalenya, Frank J. M. van Kuppeveld
Publikováno v:
mSphere, Vol 1, Iss 3 (2016)
ABSTRACT Positive-strand RNA [(+)RNA] viruses are true masters of reprogramming host lipid trafficking and synthesis to support virus genome replication. Via their membrane-associated 3A protein, picornaviruses of the genus Enterovirus (e.g., poliovi
Externí odkaz:
https://doaj.org/article/95a6ee69959a49289b7cdb53a02feac5
Autor:
Cristina M Dorobantu, Lucian Albulescu, Christian Harak, Qian Feng, Mirjam van Kampen, Jeroen R P M Strating, Alexander E Gorbalenya, Volker Lohmann, Hilde M van der Schaar, Frank J M van Kuppeveld
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005185 (2015)
Cardioviruses, including encephalomyocarditis virus (EMCV) and the human Saffold virus, are small non-enveloped viruses belonging to the Picornaviridae, a large family of positive-sense RNA [(+)RNA] viruses. All (+)RNA viruses remodel intracellular m
Externí odkaz:
https://doaj.org/article/9cd403359eff4377b3824bc5b774fca6
Autor:
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003359 (2013)
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cell
Externí odkaz:
https://doaj.org/article/31cf5bdcec9d45a18d0975801117a4ed
Publikováno v:
Journal of General Virology
The Journal of General Virology
The Journal of General Virology
Picornaviruses form replication complexes in association with membranes in structures called replication organelles. Common themes to emerge from studies of picornavirus replication are the need for cholesterol and phosphatidylinositol 4-phosphate (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b0451ac5b5bdf736eb8bf4b2b506a
Autor:
Volker Lohmann, Christian Harak, Max Meyrath, Christian Schenk, Uwe Warnken, Martina Schnölzer, Walter Mier
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein with key functions in regulating viral RNA replication and assembly. Two phosphoisoforms are discriminated by their different apparent molecular weights: a basally phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165c394dd72e19f01c8e36c460173422
https://europepmc.org/articles/PMC6258934/
https://europepmc.org/articles/PMC6258934/
Autor:
Christian Harak, Volker Lohmann, Hayat Khan, Leen Delang, Mohammed Benkheil, Pieter Leyssen, Martin James Inglis Andrews, Johan Neyts
Publikováno v:
The Journal of antimicrobial chemotherapy. 73(12)
OBJECTIVES: Many positive-stranded RNA viruses, including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA replication. Phosphatidylinositol 4-kinase III (PI4KIII)α plays an essential role in the formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c0bce4e6f7098b2a0cdb868ad01aac
https://pubmed.ncbi.nlm.nih.gov/30219827
https://pubmed.ncbi.nlm.nih.gov/30219827
Autor:
Christian Harak, Max Meyrath, Inés Romero-Brey, Christian Schenk, Claire Gondeau, Philipp Schult, Katharina Esser-Nobis, Mohsan Saeed, Petra Neddermann, Paul Schnitzler, Daniel Gotthardt, Sofia Perez-del-Pulgar, Christoph Neumann-Haefelin, Robert Thimme, Philip Meuleman, W. R. Vondran Florian, Raffaele De Francesco, Charles M. Rice, Ralf Bartenschlager, Volker Lohmann
Publikováno v:
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2017, 2 (3), ⟨10.1038/nmicrobiol.2017.12⟩
Nature Microbiology, Nature Publishing Group, 2017, 2 (3), ⟨10.1038/nmicrobiol.2017.12⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac8ae70dcc45a47646e1d1195e926e
https://pubmed.ncbi.nlm.nih.gov/27991882
https://pubmed.ncbi.nlm.nih.gov/27991882
Publikováno v:
Hepatology (Baltimore, Md.)
Hepatitis A virus (HAV) and hepatitis C virus (HCV) are two positive-strand RNA viruses sharing a similar biology, but causing opposing infection outcomes, with HAV always being cleared and HCV establishing persistence in the majority of infections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68967c69d53c0bd6d4075a71f054e9ac
https://pubmed.ncbi.nlm.nih.gov/25866017
https://pubmed.ncbi.nlm.nih.gov/25866017
Autor:
Rahel Klein, Christian Harak, Cyntia Taveneau, Danijela Radujkovic, Volker Lohmann, Stéphane Bressanelli, Simon Reiss
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an endoplasmic reticulum (ER)-resident enzyme that synthesizes phosphatidylinositol 4-phosphate (PI4P). PI4KIIIα is an essential host factor for hepatitis C virus (HCV) replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797f0d5c2e7a4abea0f64cae8ac3be7
https://europepmc.org/articles/PMC4136347/
https://europepmc.org/articles/PMC4136347/
Autor:
Danijela Radujkovic, Inés Romero-Brey, Rahel Klein, Christian Harak, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann, Alessia Ruggieri, Simon Reiss
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003359 (2013)
PLoS Pathogens
PLoS Pathogens
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c8021989562caf6208b1c4a2bbc330
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23675303/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23675303/?tool=EBI