Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Christian H. K. Lehmann"'
Autor:
Xinyi Wei, MSc, Sabine Weber, MD, Decheng Yin, MSc, Ida Allabauer, Tilman Jobst-Schwan, MD, Michael Wiesener, MD, Mario Schiffer, MD, Diana Dudziak, PhD, Christian H. K. Lehmann, PhD, Joachim Woelfle, MD, Andre Hoerning, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1666 (2024)
Background. The mammalian target of rapamycin inhibitor (mTORi) therapy after kidney transplantation is solely monitored pharmacokinetically, not necessarily reflecting PI3K-Akt-mTOR pathway blockade efficacy leading to potential under-or overimmunos
Externí odkaz:
https://doaj.org/article/701e3fa629a94ad99b283dc1d0ebf8a1
Autor:
Jian Fu, Christian H. K. Lehmann, Xinning Wang, Mandy Wahlbuhl, Ida Allabauer, Benjamin Wilde, Lukas Amon, Sebastian Dolff, Robert Cesnjevar, Andreas Kribben, Joachim Woelfle, Wolfgang Rascher, Peter F. Hoyer, Diana Dudziak, Oliver Witzke, André Hoerning
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Allograft-specific regulatory T cells (Treg cells) are crucial for long-term graft acceptance after transplantation. Although adoptive Treg cell transfer has been proposed, major challenges include graft-specificity and stability. Thus, ther
Externí odkaz:
https://doaj.org/article/aed570743c9f4d9fb446c26967b40fc2
Autor:
Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. Schraml
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cD
Externí odkaz:
https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
Autor:
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor
Externí odkaz:
https://doaj.org/article/5fcbad4a86ec408db5a8eceac4164627
Autor:
Christiane Desel, Peter J. Murray, Christian H. K. Lehmann, Lukas Heger, Dennis Christensen, Peter Andersen, Matthias Mack, Diana Dudziak, Roland Lang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Successful subunit vaccination with recombinant proteins requires adjuvants. The glycolipid trehalose-dibehenate (TDB), a synthetic analog of the mycobacterial cord factor, potently induces Th1 and Th17 immune responses and is a candidate adjuvant fo
Externí odkaz:
https://doaj.org/article/e3f89c8623f14ba7b25fd2abe6e24b5c
Autor:
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mócsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Siglec-H is a DAP12-associated receptor on plasmacytoid dendritic cells (pDCs) and microglia. Siglec-H inhibits TLR9-induced IFN-α production by pDCs. Previously, it was found that Siglec-H-deficient mice develop a lupus-like severe autoimmune disea
Externí odkaz:
https://doaj.org/article/c505db08fdab443ead7dba66ecb91da3
Autor:
Vera Buchele, Patrick Konein, Tina Vogler, Timo Kunert, Karin Enderle, Hanif Khan, Maike Büttner-Herold, Christian H. K. Lehmann, Lukas Amon, Stefan Wirtz, Diana Dudziak, Markus F. Neurath, Clemens Neufert, Kai Hildner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Inflammatory bowel diseases (IBDs) are characterized by chronic, inflammatory gastrointestinal lesions and often require life-long treatment with immunosuppressants and repetitive surgical interventions. Despite progress in respect to the characteriz
Externí odkaz:
https://doaj.org/article/b8126bfbdeea4bca8113f41e9fa8090c
Autor:
Jennifer J. Lühr, Nils Alex, Lukas Amon, Martin Kräter, Markéta Kubánková, Erdinc Sezgin, Christian H. K. Lehmann, Lukas Heger, Gordon F. Heidkamp, Ana-Sunčana Smith, Vasily Zaburdaev, Rainer A. Böckmann, Ilya Levental, Michael L. Dustin, Christian Eggeling, Jochen Guck, Diana Dudziak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system. Upon sensing pathogenic material in their environment, DCs start to mature, which includes cellular processes, such as antigen uptake, processing and presentation,
Externí odkaz:
https://doaj.org/article/7bd94d41531748c0a76c75f16f85c8c1
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 663 (2020)
The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (
Externí odkaz:
https://doaj.org/article/7cb4926558a84b5d9545a337e3f97c0b
Autor:
Lukas Heger, Silke Balk, Jennifer J. Lühr, Gordon F. Heidkamp, Christian H. K. Lehmann, Lukas Hatscher, Ariawan Purbojo, Arndt Hartmann, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Robert Cesnjevar, Falk Nimmerjahn, Diana Dudziak
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Dendritic cells (DCs) are major players for the induction of immune responses. Apart from plasmacytoid DCs (pDCs), human DCs can be categorized into two types of conventional DCs: CD141+ DCs (cDC1) and CD1c+ DCs (cDC2). Defining uniquely expressed su
Externí odkaz:
https://doaj.org/article/8ffd0c96016f4660bb2bf458c976d932