Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Christian H Wetzel"'
Autor:
Vladimir M Milenkovic, Stefanie Bader, Daniel Sudria-Lopez, Ramona Siebert, Caroline Brandl, Caroline Nothdurfter, Bernhard H F Weber, Rainer Rupprecht, Christian H Wetzel
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195627 (2018)
The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. Expression of TSPO is upregulated in activated microglia in various neuroinflammatory, neurodegenerative, a
Externí odkaz:
https://doaj.org/article/a54c0b37f0aa4b619a5418413b5b7cc1
Autor:
Ninthujah Kanageswaran, Marilen Demond, Maximilian Nagel, Benjamin S P Schreiner, Sabrina Baumgart, Paul Scholz, Janine Altmüller, Christian Becker, Julia F Doerner, Heike Conrad, Sonja Oberland, Christian H Wetzel, Eva M Neuhaus, Hanns Hatt, Günter Gisselmann
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0113170 (2015)
The ability of animals to sense and differentiate among thousands of odorants relies on a large set of olfactory receptors (OR) and a multitude of accessory proteins within the olfactory epithelium (OE). ORs and related signaling mechanisms have been
Externí odkaz:
https://doaj.org/article/622fc30a01ab4e29bf58b049c44ca275
Autor:
Nicole Schöbel, Debbie Radtke, Matthias Lübbert, Günter Gisselmann, Ramona Lehmann, Annika Cichy, Benjamin S P Schreiner, Janine Altmüller, Alan C Spector, Jennifer Spehr, Hanns Hatt, Christian H Wetzel
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48005 (2012)
Intracellular Cl(-) concentrations ([Cl(-)](i)) of sensory neurons regulate signal transmission and signal amplification. In dorsal root ganglion (DRG) and olfactory sensory neurons (OSNs), Cl(-) is accumulated by the Na(+)-K(+)-2Cl(-) cotransporter
Externí odkaz:
https://doaj.org/article/1bfce3b7eed44c2592a91682de65dfb3
Autor:
Daniela Brunert, Stefan Kurtenbach, Sonnur Isik, Heike Benecke, Günter Gisselmann, Wolfgang Schuhmann, Hanns Hatt, Christian H Wetzel
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5499 (2009)
The gaseous signalling molecule nitric oxide (NO) is involved in various physiological processes including regulation of blood pressure, immunocytotoxicity and neurotransmission. In the mammalian olfactory bulb (OB), NO plays a role in the formation
Externí odkaz:
https://doaj.org/article/c7da199594e4407d88eb94853cc5f0d6
Autor:
Lorraine Weidner, Julia Lorenz, Stefanie Quach, Frank K. Braun, Tanja Rothhammer-Hampl, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Laura M. Bartos, Franziska J. Dekorsy, Adrien Holzgreve, Sabrina V. Kirchleitner, Niklas Thon, Tobias Greve, Viktoria Ruf, Jochen Herms, Stefanie Bader, Vladimir M. Milenkovic, Louisa von Baumgarten, Ayse N. Menevse, Abir Hussein, Julian Sax, Christian H. Wetzel, Rainer Rupprecht, Martin Proescholdt, Nils O. Schmidt, Philipp Beckhove, Peter Hau, Joerg-Christian Tonn, Peter Bartenstein, Matthias Brendel, Nathalie L. Albert, Markus J. Riemenschneider
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging interpretation may be challenging.
Externí odkaz:
https://doaj.org/article/882098c23867491bad20bb37d6a6accc
Autor:
Iseline Cardon, Sonja Grobecker, Selin Kücükoktay, Stefanie Bader, Tatjana Jahner, Caroline Nothdurfter, Kevin Koschitzki, Mark Berneburg, Bernhard H. F. Weber, Heidi Stöhr, Marcus Höring, Gerhard Liebisch, Frank Braun, Tanja Rothammer-Hampl, Markus J. Riemenschneider, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 963 (2024)
The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria’s involvement in many mechanisms identified in depression and the high prevalence of MDD in individuals with mitochondrial d
Externí odkaz:
https://doaj.org/article/0dca2d547cd348c485b0ad25245fc6f3
Autor:
Elena-Sofia Heinl, Sebastian Lorenz, Barbara Schmidt, Nouf Nasser M Laqtom, Joseph R. Mazzulli, Laetitia Francelle, Timothy W. Yu, Benjamin Greenberg, Stephan Storch, Ines Tegtmeier, Helga Othmen, Katja Maurer, Malin Steinfurth, Ralph Witzgall, Vladimir Milenkovic, Christian H. Wetzel, Markus Reichold
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105082- (2022)
Summary: The SARS-CoV-2 virus has triggered a worldwide pandemic. According to the BioGrid database, CLN7 (MFSD8) is thought to interact with several viral proteins. The aim of this work was to investigate a possible involvement of CLN7 in the infect
Externí odkaz:
https://doaj.org/article/edaf365365c74efab193fd8d1643bbfe
Autor:
Stefanie Bader, Thea Würfel, Tatjana Jahner, Caroline Nothdurfter, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel
Publikováno v:
Cells, Vol 12, Iss 6, p 954 (2023)
Microglia are the resident immune cells of the central nervous system. Upon stimulus presentation, microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered a marker of inflammation. Here, we
Externí odkaz:
https://doaj.org/article/244f7a576ba84323a545994e929682f7
Autor:
Philipp Beckhove, Nisit Khandelwal, Gyorgy Vereb, Arpad Szoor, Mathias Witzens-Harig, Martin Ehrenschwender, Hartmut Goldschmidt, Dirk Hose, Anja Seckinger, Christian H. Wetzel, Mark Berneburg, Sebastian Haferkamp, Michael Boutros, Klaus Griewank, Anchana Rathinasamy, Chih-Yeh Chen, Vladimir M. Milenkovic, Madlen Ditz, Gertrud Knoll, Ayse N. Menevse, Antonio Sorrentino, Tillmann Michels, Valentina Volpin
The success of cancer immunotherapy is limited by resistance to immune checkpoint blockade. We therefore conducted a genetic screen to identify genes that mediated resistance against CTLs in anti–PD-L1 treatment–refractory human tumors. Using PD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47da9f6d9c41bd177cc4c2d2c565fac
https://doi.org/10.1158/2326-6066.c.6550054.v1
https://doi.org/10.1158/2326-6066.c.6550054.v1
Autor:
Philipp Beckhove, Nisit Khandelwal, Gyorgy Vereb, Arpad Szoor, Mathias Witzens-Harig, Martin Ehrenschwender, Hartmut Goldschmidt, Dirk Hose, Anja Seckinger, Christian H. Wetzel, Mark Berneburg, Sebastian Haferkamp, Michael Boutros, Klaus Griewank, Anchana Rathinasamy, Chih-Yeh Chen, Vladimir M. Milenkovic, Madlen Ditz, Gertrud Knoll, Ayse N. Menevse, Antonio Sorrentino, Tillmann Michels, Valentina Volpin
siRNA library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501130b551d81fdba64a9644e7286d79
https://doi.org/10.1158/2326-6066.22542847.v1
https://doi.org/10.1158/2326-6066.22542847.v1