Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Christian H Ottensmeier"'
Autor:
Liku B Tezera, Magdalena K Bielecka, Paul Ogongo, Naomi F Walker, Matthew Ellis, Diana J Garay-Baquero, Kristian Thomas, Michaela T Reichmann, David A Johnston, Katalin Andrea Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N Jayasinghe, Robert J Wilkinson, Salah Mansour, Gareth J Thomas, Christian H Ottensmeier, Alasdair Leslie, Paul T Elkington
Publikováno v:
eLife, Vol 9 (2020)
Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whereby immune
Externí odkaz:
https://doaj.org/article/26d53fc70a4d49198d9cbc54c4787117
Autor:
Salma Naheed, Chloe Holden, Lulu Tanno, Eleanor Jaynes, Christian H Ottensmeier, Giuseppe Pelosi
Publikováno v:
BMJ Open, Vol 9, Iss 8 (2019)
IntroductionThe omission of the immunohistochemical proliferation marker Ki-67 labelling index (henceforth, simply Ki-67) from the 2015 WHO classification system of pulmonary neuroendocrine tumours (Lung-NETs) as a prognostic and grading criterion re
Externí odkaz:
https://doaj.org/article/2ea55ce093c049e29b8baebbdc7129f6
Autor:
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauldie, Martin Kolb, Sumeet Mahajan, Aurelie Fabre, Atul Bhaskar, Wolfgang Jarolimek, Luca Richeldi, Katherine MA O'Reilly, Phillip D Monk, Philipp J Thurner, Donna E Davies
Publikováno v:
eLife, Vol 7 (2018)
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in hum
Externí odkaz:
https://doaj.org/article/2541e80c33c2458ba21e589aed967251
Autor:
Yifang Gao, William Rae, Keseva Ananth Ramakrishnan, Gabriela Barcenas-Morales, Rainer Döffinger, Efrem Eren, Saul N Faust, Christian H Ottensmeier, Anthony P Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155059 (2016)
The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are c
Externí odkaz:
https://doaj.org/article/8227f279a8c64bf9bb7fce5111985d4e
Autor:
Eleonora Li Causi, Suraj C Parikh, Lindsey Chudley, David M Layfield, Christian H Ottensmeier, Freda K Stevenson, Gianfranco Di Genova
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136717 (2015)
CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important. Previously
Externí odkaz:
https://doaj.org/article/85f5e9ebbe6b498eaf2416e51749a086
Autor:
Salma Naheed, Chloe Holden, Lulu Tanno, Eleanor Jaynes, Judith Cave, Giuseppe Pelosi, Neil W Pearce, Bryan Green, Linda Pattini, Christian H. Ottensmeier
Publikováno v:
BMJ Open, Vol 12, Iss 3 (2022)
Objectives Ki-67, a marker of cellular proliferation, is associated with prognosis across a wide range of tumours, including gastroenteropancreatic neuroendocrine neoplasms (NENs), lymphoma, urothelial tumours and breast carcinomas. Its omission from
Externí odkaz:
https://doaj.org/article/5482897f0b694ef68b9a885ffd792043
Autor:
William J Pandori, Lindsey E Padgett, Ahmad Alimadadi, Norma A Gutierrez, Daniel J Araujo, Christine J Huh, Claire E Olingy, Huy Q Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J Chee, Christian H Ottensmeier, Catherine C Hedrick
Publikováno v:
Journal of Leukocyte Biology. 112:1053-1063
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe immune dysfunction, hospitalization, and death. Many patients also develop long-COVID-19, experiencing symptoms
Autor:
Edward James, Tim Elliott, Gareth J. Thomas, Emma V. King, Christian H. Ottensmeier, Oliver Wood, Emma Reeves
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3abe2483bc7c8db3099086050cc0cb1
https://doi.org/10.1158/2326-6066.22542129
https://doi.org/10.1158/2326-6066.22542129
Autor:
Edward James, Tim Elliott, Gareth J. Thomas, Emma V. King, Christian H. Ottensmeier, Oliver Wood, Emma Reeves
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712a17e273db01f409d49c341090e095
https://doi.org/10.1158/2326-6066.22542135
https://doi.org/10.1158/2326-6066.22542135
Autor:
Edward James, Tim Elliott, Gareth J. Thomas, Emma V. King, Christian H. Ottensmeier, Oliver Wood, Emma Reeves
Presence of tumor-infiltrating lymphocytes (TIL) predicts survival in many cancer types. In HPV-driven cancers, cervical and oropharyngeal squamous cell carcinomas (CSCC and OPSCC, respectively), numbers of infiltrating T cells, particularly CD8+ T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4def297d031cde7b84607b9fcdc834c1
https://doi.org/10.1158/2326-6066.c.6549810
https://doi.org/10.1158/2326-6066.c.6549810