Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Christian H Haering"'
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2116-2126 (2016)
Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes. One of these factors, Pds5,
Externí odkaz:
https://doaj.org/article/173d19a667874edcac0946409763af46
Autor:
Jorine M. Eeftens, Allard J. Katan, Marc Kschonsak, Markus Hassler, Liza de Wilde, Essam M. Dief, Christian H. Haering, Cees Dekker
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1813-1818 (2016)
Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and condensin, play key roles in the regulation of higher-order chromosome organization. Even though SMC proteins are thought to mechanistically determine the function o
Externí odkaz:
https://doaj.org/article/f66a30d959e644dab67ab4ad0a8ce36c
Autor:
Clémence Hocquet, Xavier Robellet, Laurent Modolo, Xi-Ming Sun, Claire Burny, Sara Cuylen-Haering, Esther Toselli, Sandra Clauder-Münster, Lars Steinmetz, Christian H Haering, Samuel Marguerat, Pascal Bernard
Publikováno v:
eLife, Vol 7 (2018)
Condensins are genome organisers that shape chromosomes and promote their accurate transmission. Several studies have also implicated condensins in gene expression, although any mechanisms have remained enigmatic. Here, we report on the role of conde
Externí odkaz:
https://doaj.org/article/9d76ef2a02bb47c2ac8a6b183647ac2e
Publikováno v:
eLife, Vol 7 (2018)
The cohesin ring complex is required for numerous chromosomal transactions including sister chromatid cohesion, DNA damage repair and transcriptional regulation. How cohesin engages its chromatin substrate has remained an unresolved question. We show
Externí odkaz:
https://doaj.org/article/5cc5282028dc4d4ebbcaa3a2d43703b8
Autor:
Indra A. Shaltiel, Sumanjit Datta, Léa Lecomte, Markus Hassler, Marc Kschonsak, Sol Bravo, Catherine Stober, Jenny Ormanns, Sebastian Eustermann, Christian H. Haering
Publikováno v:
Science (New York, N.Y.). 376(6597)
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f6cb5b5964276abbe4a261b2ec381
https://pubmed.ncbi.nlm.nih.gov/35653469
https://pubmed.ncbi.nlm.nih.gov/35653469
Publikováno v:
Journal of Biological Chemistry
J Biol Chem
JBC papers in press 294(37), 13822-13829 (2019). doi:10.1074/jbc.RA119.008661
J Biol Chem
JBC papers in press 294(37), 13822-13829 (2019). doi:10.1074/jbc.RA119.008661
High-resolution structural analysis of flexible proteins is frequently challenging and requires the synergistic application of different experimental techniques. For these proteins, small-angle X-ray scattering (SAXS) allows for a quantitative assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e0a6cdfb509fd10ebb26410abcde0e
https://doi.org/10.1074/jbc.ra119.008661
https://doi.org/10.1074/jbc.ra119.008661
Autor:
Indra A. Shaltiel, Sebastian Eustermann, Sumanjit Datta, Christian H. Haering, Catherine Stober, Markus Hassler, Marc Kschonsak, Léa Lecomte, Sol Bravo
Publikováno v:
bioRxiv pre
bioRxiv
bioRxiv
SMC protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a DNA loop in two separate chambers. Single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb6854c4702979cf4d07eaace967608
Autor:
Pilar Gutiérrez-Escribano, Matteo Allegretti, Jan Löwe, Francis J. O’Reilly, Christopher Cawood, Luis Aragón, Ludwig Sinn, Martin Beck, Byung-Gil Lee, Christian H. Haering, Léa Lecomte, Juri Rappsilber, Fabian Merkel, Takanori Nakane, Sol Bravo, Markus Hassler, Marc Kschonsak
Publikováno v:
Nat Struct Mol Biol
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology
Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of genomes in all domains of life. The eukaryotic SMC complexes cohesin and condensin are thought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9787bd257114a4c8cf8b0299b0ece5c3
https://pubmed.ncbi.nlm.nih.gov/32661420
https://pubmed.ncbi.nlm.nih.gov/32661420
Publikováno v:
Current Biology
Protein complexes built of Structural Maintenance of Chromosomes (SMC) and kleisin subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of genome architecture in all kingdoms of life. How these large ring-shaped molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b7c493bd2374630e01c4bdcfc0fcd2
https://doi.org/10.1016/j.cub.2018.08.034
https://doi.org/10.1016/j.cub.2018.08.034
Autor:
Je-Kyung, Ryu, Allard J, Katan, Eli O, van der Sluis, Thomas, Wisse, Ralph, de Groot, Christian H, Haering, Cees, Dekker
Publikováno v:
Nature structuralmolecular biology. 27(12)
Structural maintenance of chromosome (SMC) protein complexes are the key organizers of the spatiotemporal structure of chromosomes. The condensin SMC complex has recently been shown to be a molecular motor that extrudes large loops of DNA, but the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca95c70c5f9bd56f5d906b4000169a54
https://pubmed.ncbi.nlm.nih.gov/33033391
https://pubmed.ncbi.nlm.nih.gov/33033391