Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christian Grune"'
Autor:
Anna Czapka, Christian Grune, Patrick Schädel, Vivien Bachmann, Karl Scheuer, Michael Dirauf, Christine Weber, Alexios-Leandros Skaltsounis, Klaus D. Jandt, Ulrich S. Schubert, Dagmar Fischer, Oliver Werz
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Background Insufficient solubility and stability of bioactive small molecules as well as poor biocompatibility may cause low bioavailability and are common obstacles in drug development. One example of such problematic molecules is 6-bromoin
Externí odkaz:
https://doaj.org/article/7e866acb2ae44fc1a0e00d5facfa2b2c
Autor:
Christian Kretzer, Stephanie Hoeppener, Dagmar Fischer, Christian Grune, Stephanie Zergiebel, Oliver Werz, Sven Kattner, Jana Thamm
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1843-1850
Diflapolin is a dual FLAP/sEH inhibitor with potent anti-inflammatory efficiency in cellular assays and experimental in vivo studies. Despite these outstanding characteristics, its high lipophilicity and plasma protein binding hamper the bioactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad930c39fab923fc0e8dccea60873a5
https://doi.org/10.1016/j.xphs.2021.10.030
https://doi.org/10.1016/j.xphs.2021.10.030
Publikováno v:
Journal of Pharmaceutical Sciences. 110:959-964
Toxic and environmental harmful organic solvents are widely applied to prepare poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NP) in standard preparation methods. Alternative non-toxic solvents suffer from disadvantages like high viscosity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea0eb9348db37ea6bd399f7c8757913
https://doi.org/10.1016/j.xphs.2020.11.031
https://doi.org/10.1016/j.xphs.2020.11.031
Autor:
Maren T. Kuchenbrod, Fabian H. Sobotta, Johannes C. Brendel, Stephanie Hoeppener, Christian Grune, Dagmar Fischer
Publikováno v:
Polymer Chemistry. 12:1668-1680
Polymerization-induced self-assembly (PISA) is an emerging methodology for the in situ preparation of complex polymeric nanostructures in aqueous solution. However, the scope of monomers allowing morphology transitions remains limited, which is relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e991362968318bd04f57754716ad8ef
https://doi.org/10.1039/d0py01697g
https://doi.org/10.1039/d0py01697g
Autor:
Thorsten Heinzel, Marc Thilo Figge, Zoltán Cseresnyés, Maren Godmann, Marie Kühne, Andreas Koschella, Henry Lindemann, Daniel Schröder, Christian Grune, Dagmar Fischer, Thomas Heinze, Christian Eggeling
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 329
The development of bio-based nanoparticles (NPs) as drug containers is of increasing interest to circumvent several obstacles in drug therapy such as rapid drug metabolization, short serum half-life, and unspecific side effects. The histone deacetyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a61e101b9861ee999c7cee6d643f76
https://pubmed.ncbi.nlm.nih.gov/33031880
https://pubmed.ncbi.nlm.nih.gov/33031880
Autor:
Wolfgang Dr. Fischer, David Bär, Heiko Debus, Christian Grune, Karsten Mäder, Peter Imming, Stephan Dr. Tosch
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 121:90-96
Naproxen is a typical and well-known analgesic classified as non-steroidal anti-inflammatory drug (NSAID) and is commercialized as tablets or liquid-filled capsules. Naproxen is typically used as a sodium salt because of its better processability com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394910db0c63a6da3e90bf85e4598428
https://doi.org/10.1016/j.ejpb.2017.09.011
https://doi.org/10.1016/j.ejpb.2017.09.011
Autor:
Karl Scheuer, Anna Czapka, Ute Neugebauer, Clara Zens, Christian Grune, Dagmar Fischer, Jana Thamm, Oliver Werz, Stephanie Hoeppener, Klaus D. Jandt
Publikováno v:
International Journal of Pharmaceutics. 599:120404
In the present study, the anti-inflammatory lipophilic drug atorvastatin was encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) using a sustainable method in comparison to the standard emulsion-diffusion-evaporation technique. For the sustainable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c125fd06cf6741acdf9a1f5ac1c05f
https://doi.org/10.1016/j.ijpharm.2021.120404
https://doi.org/10.1016/j.ijpharm.2021.120404
Autor:
Anna Czapka, Stefanie König, Alexios-Leandros Skaltsounis, Carlo Pergola, Oliver Werz, Konstantina Vougogiannopoulou, Christian Grune, Dagmar Fischer
Publikováno v:
Biochemical Pharmacology. 180:114170
Indirubin is a natural bis-indole alkaloid contained as active ingredient in the traditional Chinese remedy Danggui Longhui Wan. Indirubin and its 3′-oxime derivatives exhibit anti-cancer and anti-inflammatory properties and they inhibit glycogen s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3e81c9ec39f57b128b5dd28dc05f83
https://doi.org/10.1016/j.bcp.2020.114170
https://doi.org/10.1016/j.bcp.2020.114170
Autor:
Andreas Koschella, Marie Kühne, Paul Warncke, Thorsten Heinzel, Maren Godmann, Christian Grune, Henry Lindemann, Dagmar Fischer, Thomas Heinze, Susanne Hofmann
Publikováno v:
Macromolecular Bioscience. 20:2000039
The histone deacetylase inhibitors (HDACi) are potent drugs in the treatment of inflammatory diseases and defined cancer types. However, major drawbacks of HDACi, such as valproic acid (VPA), are limited serum half-life, side effects and the short ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8de99147c2637bb1d9dd997929fcb4
https://doi.org/10.1002/mabi.202000039
https://doi.org/10.1002/mabi.202000039
