Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christian Grossardt"'
Autor:
Hans Martin Singh, Mathias Felix Leber, Sascha Bossow, Christine E. Engeland, Jan Dessila, Christian Grossardt, Karim Zaoui, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss , Pp 340-355 (2021)
Advanced pancreatic cancer is characterized by few treatment options and poor outcomes. Oncolytic virotherapy and chemotherapy involve complementary pharmacodynamics and could synergize to improve therapeutic efficacy. Likewise, multimodality treatme
Externí odkaz:
https://doaj.org/article/95b9c48283a54a47bc599fb72e9ab78d
Autor:
Sascha Bossow, Dirk Jäger, Christine E. Engeland, Christian Grossardt, Hans Martin Singh, Christof von Kalle, John C. Bell, Jan Dessila, Mathias F. Leber, Guy Ungerechts, Karim Zaoui
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 340-355 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Advanced pancreatic cancer is characterized by few treatment options and poor outcomes. Oncolytic virotherapy and chemotherapy involve complementary pharmacodynamics and could synergize to improve therapeutic efficacy. Likewise, multimodality treatme
Autor:
Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, Christine E. Engeland
Publikováno v:
OncoImmunology, Vol 6, Iss 4 (2017)
Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different
Externí odkaz:
https://doaj.org/article/c94806dbf0f84599a829ae67877d0ae8
Autor:
Christian Grossardt, Sascha Bossow, Ivan Shevchenko, Christof von Kalle, Dirk M. Nettelbeck, Diana Lutz, Wilko Weichert, Rūta Veinalde, Viktor Umansky, Guy Ungerechts, Dirk Jäger, Christine E. Engeland, Johanna K. Kaufmann
Publikováno v:
Molecular Therapy. 22(11):1949-1959
We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors en
Autor:
M A Baertsch, Sascha Bossow, M Singh, Jessica Albert, Mathias F. Leber, Christine E. Engeland, Guy Ungerechts, C von Kalle, Christian Grossardt, Dirk Jäger
Publikováno v:
Cancer Gene Therapy. 21:373-380
Precise oncotropism is required for successful systemic administration of next-generation oncolytic measles viruses (MVs). We have previously established a system for efficient post-entry targeting by insertion of synthetic microRNA target sites (miR
Autor:
Rūta Veinalde, Christian Grossardt, John C. Bell, Christine E. Engeland, Guy Ungerechts, Laura Hartmann, Dirk Jäger, Marie-Claude Bourgeois-Daigneault, Christof von Kalle
Publikováno v:
OncoImmunology, Vol 6, Iss 4 (2017)
Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different
Autor:
Christian Grossardt, Guy Ungerechts, Christof von Kalle, Marie-Claude Bourgeois-Daigneault, Christine E. Engeland, Dirk Jaeger, Rūta Veinalde
Publikováno v:
Cancer Immunology Research. 4:A068-A068
Replicating oncolytic viruses (OVs) are emerging as a promising therapeutic approach for different tumor entities. Positive data from numerous clinical studies are accumulating and as a first-in-class oncolytic herpes virus encoding GM-CSF, Talimogen
Autor:
Christian Grossardt, A Temme, Guy Ungerechts, C von Kalle, E P Rieber, Sascha Bossow, Roberto Cattaneo, Stefanie Sawall, Mathias F. Leber
Publikováno v:
Cancer Gene Therapy. 18:598-608
No curative therapy is currently available for locally advanced or metastatic pancreatic cancer. Therefore, new therapeutic approaches must be considered. Measles virus (MV) vaccine strains have shown promising oncolytic activity against a variety of
Publikováno v:
Tissue Engineering Part A. 16:3687-3695
Biocements are clinically applied materials for bone replacement in non-load-bearing defects. Depending on their final composition, cements can be either resorbed or remain stable at the implantation site. Degradation can occur by two different mecha
Autor:
Rūta Veinalde, Christof von Kalle, Christine E. Engeland, Guy Ungerechts, Christian Grossardt, Dirk Jäger
Publikováno v:
Molecular Therapy. 23:S247-S248
We hypothesized that combining oncolytic Measles virus (MV) with immune checkpoint modulation using antibodies which block CTLA-4 and PD-1/PD-L1 signaling can provide synergistic antitumor effects.Targeted immunomodulatory MV vectors encoding checkpo