Results from (11)C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

Autor: Jørgen Frøkiær, Michael R. Horsman, Christian Garm, Steen Jakobsen, Ane B. Iversen, Morten Busk, Peter Breining, Niels Jessen, Jonas Jensen

Publikováno v: Iversen, A B, Horsman, M R, Jakobsen, S, Jensen, J B, Garm, C, Jessen, N, Breining, P, Frøkiær, J & Busk, M 2017, ' Results from (11)C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly ', Scientific Reports, vol. 7, no. 1, 9436, pp. 9436 . https://doi.org/10.1038/s41598-017-10010-z
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e9f64d95e2e6d6159a8ecb1866a2d4
https://pure.au.dk/portal/da/publications/results-from-11cmetforminpet-scans-tissue-analysis-and-cellular-drugsensitivity-assays-questions-the-view-that-biguanides-affects-tumor-respiration-directly(7d9755b8-8a26-47aa-85fe-a4ae1595a629).html

Genetic and environmental influence on DNA strand break repair:A twin study

Autor: Christian, Garm, Maria, Moreno-Villanueva, Alexander, Bürkle, Lisbeth Aagaard, Larsen, Vilhelm A, Bohr, Kaare, Christensen, Tinna, Stevnsner

Publikováno v: Garm, C, Moreno-Villanueva, M, Bürkle, A, Larsen, L A, Bohr, V, Christensen, K & Stevnsner, T V 2013, ' Genetic and environmental influence on DNA strand break repair : A twin study ', Environmental and Molecular Mutagenesis. Supplement, vol. 54, no. 6, pp. 414-420 . https://doi.org/10.1002/em.21791
Garm, C, Moreno-Villanueva, M, Bürkle, A, Larsen, L A, Bohr, V A, Christensen, K & Stevnsner, T V 2013, ' Genetic and environmental influence on DNA strand break repair: a twin study ', Environmental and Molecular Mutagenesis, vol. 54, no. 6, pp. 414-420 . https://doi.org/10.1002/em.21791

Accumulation of DNA damage deriving from exogenous and endogenous sources has significant consequences for cellular survival, and is implicated in aging, cancer, and neurological diseases. Different DNA repair pathways have evolved in order to mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::29f4aa833d5aa1d2e714ca0d4bd7bc66
https://portal.findresearcher.sdu.dk/da/publications/d4a7fa65-cf43-4436-bcce-4317c39170d7

Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems

Autor: Christian Garm, Ricardo Gredilla, Tinna Stevnsner

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2012 (2012)
Gredilla, R, Garm, C & Stevnsner, T 2012, ' Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems ', Oxidative Medicine and Cellular Longevity, vol. 2012 . https://doi.org/10.1155/2012/282438

Knowledge about the different mechanisms underlying the aging process has increased exponentially in the last decades. The fact that the basic mechanisms involved in the aging process are believed to be universal allows the use of different model sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80515552b54a340664e523718c90f96
https://pubmed.ncbi.nlm.nih.gov/23050036

107 Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

Autor: Tinna Stevnsner, Christian Garm, Vilhelm A. Bohr, Lior Weissman, Rikke Holm, Ricardo Gredilla

Publikováno v: Mitochondrion. 10:230

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c27eb4373e880d01a0d51184c6dcb6ef
https://doi.org/10.1016/j.mito.2009.12.099