Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Christian Gaiddon"'
Autor:
Jana Mourtada, Christelle Lony, Anaïs Nicol, Justine De Azevedo, Cyril Bour, Christine Macabre, Patrick Roncarati, Sonia Ledrappier, Philippe Schultz, Christian Borel, Mickaël Burgy, Bohdan Wasylyk, Georg Mellitzer, Michaël Herfs, Christian Gaiddon, Alain C. Jung
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDeconvoluting the heterogenous prognosis of Human Papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OSCC) is crucial for enhancing patient care, given its rapidly increasing incidence in western countries and the adverse s
Externí odkaz:
https://doaj.org/article/bf2a6ac09adb4bfcbe807400b5a4314a
Autor:
Lidan Hou, Yichao Hou, Yu Liang, Baiyu Chen, Xintian Zhang, Yu Wang, Kun Zhou, Ting Zhong, Bohan Long, Wenjing Pang, Lei Wang, Xu Han, Linjing Li, Ci Xu, Isabelle Gross, Christian Gaiddon, Wei Fu, Han Yao, Xiangjun Meng
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A peptide that specifically targets amino acid transporter SLC1A5 in colorectal cancer cells is identified and conjugated with camptothecin to show selective cytotoxicity to colorectal cancer cells in preclinical models.
Externí odkaz:
https://doaj.org/article/ad93e759398740ccabb311ba9e5bad08
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The development of cancers is often linked to the alteration of essential redox processes, and therefore, oxidoreductases involved in such mechanisms can be considered as attractive molecular targets for the development of new therapeutic strategies.
Externí odkaz:
https://doaj.org/article/95c21855c0da44e6a7a66d34200d4c4f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In the light of the success and the expected growth of its arsenal, immuno-therapy may become the standard neoadjuvant procedure for many cancers in the near future. However, aspects such as the identity, organization and the activation status of the
Externí odkaz:
https://doaj.org/article/24fe603f6808498385130df6205f42d5
Publikováno v:
Cancers, Vol 14, Iss 21, p 5472 (2022)
Gastric cancer (GC) is one of the most aggressive cancers. Therapeutic treatments are based on surgery combined with chemotherapy using a combination of platinum-based agents. However, at metastatic stages of the disease, survival is extremely low du
Externí odkaz:
https://doaj.org/article/266889bab61b44e6a53151c123db55b6
Autor:
Justine De Azevedo, Jana Mourtada, Cyril Bour, Véronique Devignot, Philippe Schultz, Christian Borel, Erwan Pencreach, Georg Mellitzer, Christian Gaiddon, Alain C. Jung
Publikováno v:
Cells, Vol 11, Iss 18, p 2866 (2022)
(1) Background: The first line of treatment for recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) has recently evolved with the approval of immunotherapies that target the anti-PD-1 immune checkpoint. However, only about 20% of the p
Externí odkaz:
https://doaj.org/article/44a521a4cd23489a8063ed49c377a312
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1788 (2021)
Metal complexes based on transition metals have rich photochemical and photophysical properties that are derived from a variety of excited state electronic configurations triggered by visible and near-infrared light. These properties can be exploited
Externí odkaz:
https://doaj.org/article/4d47f3e6afdc4f6f9035d0ce13af5040
Autor:
Christian Gaiddon, Isabelle Gross, Xiangjun Meng, Marjorie Sidhoum, Georg Mellitzer, Benoit Romain, Jean-Batiste Delhorme, Aïna Venkatasamy, Alain C. Jung, Michel Pfeffer
Publikováno v:
Molecules, Vol 26, Iss 17, p 5386 (2021)
Metal complexes have been used to treat cancer since the discovery of cisplatin and its interaction with DNA in the 1960’s. Facing the resistance mechanisms against platinum salts and their side effects, safer therapeutic approaches have been sough
Externí odkaz:
https://doaj.org/article/b7400c923711400785a70f525d7f3528
Autor:
Aina Venkatasamy, Eric Guerin, Anais Blanchet, Christophe Orvain, Véronique Devignot, Matthieu Jung, Alain C. Jung, Marie-Pierre Chenard, Benoit Romain, Christian Gaiddon, Georg Mellitzer
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1485 (2021)
The reasons behind the poor efficacy of transition metal-based chemotherapies (e.g., cisplatin) or targeted therapies (e.g., histone deacetylase inhibitors, HDACi) on gastric cancer (GC) remain elusive and recent studies suggested that the tumor micr
Externí odkaz:
https://doaj.org/article/bb3db2c261f34fae99f13ec7309f2986
Autor:
Maria Dalla Pozza, Christophe Orvain, Leonardo Brustolin, Nicolò Pettenuzzo, Chiara Nardon, Christian Gaiddon, Dolores Fregona
Publikováno v:
Molecules, Vol 26, Iss 13, p 4073 (2021)
Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher
Externí odkaz:
https://doaj.org/article/939376302eae4ffbb2670cac01a8bc13