Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christian Gach"'
Autor:
Kostas Patas, Anne Willing, Cüneyt Demiralay, Jan Broder Engler, Andreea Lupu, Caren Ramien, Tobias Schäfer, Christian Gach, Laura Stumm, Kenneth Chan, Marissa Vignali, Petra C. Arck, Manuel A. Friese, Ole Pless, Klaus Wiedemann, Agorastos Agorastos, Stefan M. Gold
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
While a link between inflammation and the development of neuropsychiatric disorders, including major depressive disorder (MDD) is supported by a growing body of evidence, little is known about the contribution of aberrant adaptive immunity in this co
Externí odkaz:
https://doaj.org/article/43e02fb48ed7486e93fc52ea4c0a1759
Autor:
Reine El Omar, Naoill Abdellaoui, Safiatou T. Coulibaly, Laura Fontenille, François Lanza, Christian Gachet, Jean-Noel Freund, Matteo Negroni, Karima Kissa, Manuela Tavian
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-10 (2024)
Abstract Zebrafish is widely adopted as a grafting model for studying human development and diseases. Current zebrafish xenotransplantations are performed using embryo recipients, as the adaptive immune system, responsible for host versus graft rejec
Externí odkaz:
https://doaj.org/article/f6918c37b1294da69647987e0d15f79e
Autor:
Robert H. Lee, Dorsaf Ghalloussi, Gabriel L. Harousseau, Joseph P. Kenny, Patrick A. Kramer, Fabienne Proamer, Bernhard Nieswandt, Matthew J. Flick, Christian Gachet, Caterina Casari, Anita Eckly, Wolfgang Bergmeier
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Platelet homeostasis is dependent on a tight regulation of both platelet production and clearance. The small GTPase Rap1 mediates platelet adhesion and hemostatic plug formation. However, Rap1 signaling is also critical for platelet homeostasis as bo
Externí odkaz:
https://doaj.org/article/2186e8e3188e42de854d0ccf9a4a23a7
Autor:
Cyril Scandola, Mathieu Erhardt, Jean-Yves Rinckel, Fabienne Proamer, Christian Gachet, Anita Eckly
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 589-598 (2020)
Electron microscopy (EM) has a long history in megakaryocyte (MK) cellular biology. This chapter shows how the electron microscope, since its first appearance almost 90 years ago, has occupied center stage in the studies of MK morphology and function
Externí odkaz:
https://doaj.org/article/fa54f38a50e14b71981c6de83cf40757
Autor:
Muhammad Usman Ahmed, Nicolas Receveur, Emily Janus‐Bell, Clarisse Mouriaux, Christian Gachet, Martine Jandrot‐Perrus, Béatrice Hechler, Elizabeth E. Gardiner, Pierre H. Mangin
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 5, Pp n/a-n/a (2021)
Abstract Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforc
Externí odkaz:
https://doaj.org/article/79f281201ef34fe6b728f32d8e5e66e2
Publikováno v:
TH Open, Vol 05, Iss 03, Pp e343-e352 (2021)
Introduction Platelets are increasingly appreciated as key effectors during sepsis, raising the question of the usefulness of antiplatelet drugs to treat patients with sepsis. Objective Evaluate the potential contribution of the platelet P2Y12 recept
Externí odkaz:
https://doaj.org/article/202cb5d54c74438592c042c9529cec14
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 615-625 (2019)
Abstract Laboratory tests of platelet function are instrumental in studying platelet physiology and inherited or acquired platelet abnormalities. Light transmission aggregometry, developed in the early 1960s, is still considered the gold standard for
Externí odkaz:
https://doaj.org/article/9d2715bd8f5346b191f00692f9895819
Autor:
Alicia Aguilar, Josiane Weber, Julie Boscher, Monique Freund, Catherine Ziessel, Anita Eckly, Stéphanie Magnenat, Catherine Bourdon, Béatrice Hechler, Pierre H. Mangin, Christian Gachet, François Lanza, Catherine Léon
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2368-2380 (2019)
Abstract: The biogenesis of lysosome related organelles is defective in Hermansky-Pudlak syndrome (HPS), a disorder characterized by oculocutaneous albinism and platelet dense granule (DG) defects. The first animal model of HPS was the fawn-hooded ra
Externí odkaz:
https://doaj.org/article/f9d29b63529c4e02b39d934bab4263b3
Autor:
David Marx, Sophie Caillard, Jérôme Olagne, Bruno Moulin, Thierry Hannedouche, Guy Touchard, Arnaud Dupuis, Christian Gachet, Anne Molitor, Seiamak Bahram, Raphael Carapito
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Background Podocalyxin (PODXL) is a highly sialylated adhesion glycoprotein that plays an important role in podocyte's physiology. Recently, missense and nonsense dominant variants in the PODXL gene have been associated with focal segmental
Externí odkaz:
https://doaj.org/article/4e9f4409361b4fa6b0d6718d8aaead75