Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Autor: Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading causes of mortality w

Externí odkaz: https://doaj.org/article/0df3d79819534a4786cd65226889c413

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Autor: Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/3b72cd72017f45ae91810eb4f3826d16

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Autor: Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza, Luke A. J. O’Neill

Publikováno v: Hooftman, A, G. Peace, C, G. Ryan, D, A. Day, E, Yang, M, F. McGettrick, A, Yin, M, N. Montano, E, Huo, L, E. Toller-Kawahisa, J, Zecchini, V, A. J. Ryan, T, Bolado Carrancio, A, M. Casey, A, A. Prag, H, S.H. Costa, A, De Los Santos, G, Ishimori, M, J. Wallace, D, Venuturupalli, S, Nikitopoulou, E, Frizzell, N, Johansson, C, von Kriegsheim, A, P. Murphy, M, Jefferies, C, Frezza, C & A.J. O'Neill, L 2023, ' Macrophage fumarate hydratase restrains mtRNA-mediated interferon production ', Nature, vol. 615, pp. 490-498 . https://doi.org/10.1038/s41586-023-05720-6

Metabolic rewiring underlies the effector functions of macrophages 1–3, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate–arginin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1440c30dd8894932c61643e40d2cc0cc
http://hdl.handle.net/10044/1/104575

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Autor: Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, Maria A. Argiriadi, Anne F. McGettrick, Rui Santalla Mendez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Y. Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke A.J. O’Neill

Publikováno v: Cell Metabolism

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" macrophages can take up itaconate. We therefore examined the effect of ita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5063071129ec16a8b6ae0c901c165b8
https://doi.org/10.1016/j.cmet.2022.02.002