Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Christian Frezza"'
Autor:
Marlous Kamp, Jakub Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah E. Bohndiek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Aberrantly accumulated metabolites elicit intra- and inter-cellular pro-oncogenic cascades, yet current measurement methods require sample perturbation/disruption and lack spatio-temporal resolution, limiting our ability to fully characteriz
Externí odkaz:
https://doaj.org/article/8659ea9da0fc40959c45b06746f55cb7
Autor:
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana SH Costa, Antonio Esposito, Angelo D’Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1379-1403 (2024)
Abstract Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the e
Externí odkaz:
https://doaj.org/article/85f00a3b22fa420a87b07c2ca8140bde
Autor:
Cherif Badja, Sophie Momen, Gene Ching Chiek Koh, Soraya Boushaki, Theodoros I. Roumeliotis, Zuza Kozik, Ian Jones, Vicky Bousgouni, João M.L. Dias, Marios G. Krokidis, Jamie Young, Hongwei Chen, Ming Yang, France Docquier, Yasin Memari, Lorea Valcarcel-Zimenez, Komal Gupta, Li Ren Kong, Heather Fawcett, Florian Robert, Salome Zhao, Andrea Degasperi, Yogesh Kumar, Helen Davies, Rebecca Harris, Christian Frezza, Chryssostomos Chatgilialoglu, Robert Sarkany, Alan Lehmann, Chris Bakal, Jyoti Choudhary, Hiva Fassihi, Serena Nik-Zainal
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114243- (2024)
Summary: Xeroderma pigmentosum (XP) is caused by defective nucleotide excision repair of DNA damage. This results in hypersensitivity to ultraviolet light and increased skin cancer risk, as sunlight-induced photoproducts remain unrepaired. However, m
Externí odkaz:
https://doaj.org/article/3afcfcc423e04f808db8a71c2cb5d72f
Autor:
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and metastatic renal cancer cells grown in a physiological medium and show that the re
Externí odkaz:
https://doaj.org/article/5e44e98a96b7403ead5d644996d99bb6
Autor:
Connor Rogerson, Marco Sciacovelli, Lucas A. Maddalena, Andromachi Pouikli, Marc Segarra-Mondejar, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S. Carroll, Gavin Kelsey, Christian Frezza
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112751- (2023)
Summary: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to profound epigenetic cha
Externí odkaz:
https://doaj.org/article/4a018807958940d294037e2083e5da34
Autor:
Amin Mottahedin, Hiran A. Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J. Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M. Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P. Murphy, Thomas Krieg
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102600- (2023)
Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury. Previous data in experimental models of stroke show that ischemia leads to the
Externí odkaz:
https://doaj.org/article/41b646b7b62b4c0d9fe37775e8348c63
Autor:
Emanuel Gonçalves, Christian Frezza
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/4f0fa3293e9e4f4fa78370a8d6f439c9
Autor:
Mimmi LE Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, Filipa M Lebre, Aoife L Gorman, Bojan Stojkovic, Adrian P Bracken, Christian Frezza, Frederick J Sheedy, Eoin M Scanlan, Luke AJ O'Neill, Stephen V Gordon, Ed C Lavelle
Publikováno v:
eLife, Vol 11 (2022)
Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the ‘classically activated’ M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as M
Externí odkaz:
https://doaj.org/article/dfb7ec54071d42919b18133a72d40a8b
Autor:
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relev
Externí odkaz:
https://doaj.org/article/4b6d4a30886f478a8c8fe16da840f895
Autor:
Aurelien Dugourd, Christoph Kuppe, Marco Sciacovelli, Enio Gjerga, Attila Gabor, Kristina B. Emdal, Vitor Vieira, Dorte B. Bekker‐Jensen, Jennifer Kranz, Eric.M.J. Bindels, Ana S.H. Costa, Abel Sousa, Pedro Beltrao, Miguel Rocha, Jesper V. Olsen, Christian Frezza, Rafael Kramann, Julio Saez‐Rodriguez
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 1, Pp 1-17 (2021)
Abstract Multi‐omics datasets can provide molecular insights beyond the sum of individual omics. Various tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypothese
Externí odkaz:
https://doaj.org/article/abed4b2b8c774309840409241b4f91e0