Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Christian Frøkjær-Jensen"'
Autor:
Mohammed D. Aljohani, Sonia El Mouridi, Monika Priyadarshini, Amhed M. Vargas-Velazquez, Christian Frøkjær-Jensen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.
Externí odkaz:
https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d
Autor:
Xintao Fan, Sasha De Henau, Julia Feinstein, Stephanie I. Miller, Bingjie Han, Christian Frøkjær-Jensen, Erik E. Griffin
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 635-644 (2020)
Externí odkaz:
https://doaj.org/article/c391dcc97cc14930a731daffd5b89848
Autor:
Theresa L. B. Edelman, Katherine A. McCulloch, Angela Barr, Christian Frøkjær-Jensen, Erik M. Jorgensen, Ann E. Rougvie
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4077-4086 (2016)
The Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has b
Externí odkaz:
https://doaj.org/article/864ab8fcfe324e21b93bad626feb287f
Autor:
Bayly S Wheeler, Erika Anderson, Christian Frøkjær-Jensen, Qian Bian, Erik Jorgensen, Barbara J Meyer
Publikováno v:
eLife, Vol 5 (2016)
Changes in chromosome number impair fitness by disrupting the balance of gene expression. Here we analyze mechanisms to compensate for changes in gene dose that accompanied the evolution of sex chromosomes from autosomes. Using single-copy transgenes
Externí odkaz:
https://doaj.org/article/d1ea829db09d461e87de68b1babafe96
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20082 (2011)
Here we describe a toolkit for the production of fluorescently tagged proteins in the C. elegans germline and early embryo using Mos1-mediated single copy insertion (MosSCI) transformation. We have generated promoter and 3'UTR fusions to sequences of
Externí odkaz:
https://doaj.org/article/d9bb8d1994164cae81eb7221599ffaad
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2467 (2008)
Caenorhabditis elegans chemosensation has been successfully studied using behavioral assays that treat detection of volatile and water soluble chemicals as separate senses, analogous to smell and taste. However, considerable ambiguity has been associ
Externí odkaz:
https://doaj.org/article/5006fd4fcff343b7baacd315525c20f3
Autor:
Monika Priyadarshini, Julie Zhouli Ni, Amhed M. Vargas-Velazquez, Sam Guoping Gu, Christian Frøkjær-Jensen
Publikováno v:
Nat Methods
Single-guide RNAs can target exogenous CRISPR-Cas proteins to unique DNA locations, enabling genetic tools that are efficient, specific and scalable. Here we show that short synthetic guide Piwi-interacting RNAs (piRNAs) (21-nucleotide sg-piRNAs) exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2197dfc0d9fafc96cbb87dc6426580
https://doi.org/10.1038/s41592-021-01369-z
https://doi.org/10.1038/s41592-021-01369-z
Precise expression of transgenes in C. elegans can be used to understand gene regulation, control cells, or as a starting point for genetic screens. Inserting single-copy transgenes into well-defined safe-harbor locations is useful when consistent ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfd59da385e6b673be46cf72febb17d
https://doi.org/10.21203/rs.3.rs-2153916/v1
https://doi.org/10.21203/rs.3.rs-2153916/v1
Precise expression of transgenes in C. elegans can be used to understand gene regulation, control cells, or as a starting point for genetic screens. Insertion of single-copy transgenes into well-defined safe-harbor locations is useful when consistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c994dd09f56a1ce21659f2c8648521da
https://doi.org/10.21203/rs.3.rs-2053151/v1
https://doi.org/10.21203/rs.3.rs-2053151/v1
Transgene expression in C. elegans is an important tool for understanding regulatory elements (e.g., promoters and enhancers), for controlling cells using optogenetic effector proteins, and for editing the (epi)genome. Insertion of single-copy transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2874b485651bf0623c0652050121d165
https://doi.org/10.21203/rs.3.rs-2006553/v2
https://doi.org/10.21203/rs.3.rs-2006553/v2