Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christian Flueck"'
Autor:
Christopher J. Day, Paola Favuzza, Sabrina Bielfeld, Thomas Haselhorst, Leonie Seefeldt, Julia Hauser, Lucy K. Shewell, Christian Flueck, Jessica Poole, Freda E.-C. Jen, Anja Schäfer, Jean-Pierre Dangy, Tim-W. Gilberger, Camila Tenorio França, Manoj T. Duraisingh, Marco Tamborrini, Nicolas M.B. Brancucci, Christof Grüring, Michael Filarsky, Michael P. Jennings, Gerd Pluschke
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114012- (2024)
Summary: Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential for erythrocyte invasion. The pr
Externí odkaz:
https://doaj.org/article/b1552435879b4808a30ae832a3d6786d
Autor:
Suzanne E. Hocking, Lindsay B. Stewart, Aline Freville, Adam J. Reid, Sarah J. Tarr, Kevin K. A. Tetteh, Christian Flueck, Ambroise D. Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite, Gordon A. Awandare, David J. Conway
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The merozoite surface protein MSPDBL2 of Plasmodium falciparum is under strong balancing selection and is a target of naturally acquired antibodies. Remarkably, MSPDBL2 is expressed in only a minority of mature schizonts of any cultured para
Externí odkaz:
https://doaj.org/article/30b1ad20f7684bbc9cf4c1dae765475b
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The clinical manifestations of malaria arise due to successive rounds of replication of Plasmodium
Externí odkaz:
https://doaj.org/article/002c8011b3bc41a3a9ea405439021f8a
Autor:
Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin enco
Externí odkaz:
https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Autor:
Margarida Ressurreição, James A Thomas, Stephanie D Nofal, Christian Flueck, Robert W Moon, David A Baker, Christiaan van Ooij
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235798 (2020)
During the course of the asexual erythrocytic stage of development, Plasmodium spp. parasites undergo a series of morphological changes and induce alterations in the host cell. At the end of this stage, the parasites egress from the infected cell, af
Externí odkaz:
https://doaj.org/article/80f4886ea7234c70a100a8f50abd34f2
Autor:
Avnish Patel, Abigail J Perrin, Helen R Flynn, Claudine Bisson, Chrislaine Withers-Martinez, Moritz Treeck, Christian Flueck, Giuseppe Nicastro, Stephen R Martin, Andres Ramos, Tim W Gilberger, Ambrosius P Snijders, Michael J Blackman, David A Baker
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000264 (2019)
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disr
Externí odkaz:
https://doaj.org/article/2be28e1039ea4a58a0e34dc0e05e7111
Autor:
Christian Flueck, Laura G Drought, Andrew Jones, Avnish Patel, Abigail J Perrin, Eloise M Walker, Stephanie D Nofal, Ambrosius P Snijders, Michael J Blackman, David A Baker
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000154 (2019)
Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain en
Externí odkaz:
https://doaj.org/article/f2dfa91a00fe4670be575d3637a30657
Autor:
David A. Baker, Laura G. Drought, Christian Flueck, Stephanie D. Nofal, Avnish Patel, Maria Penzo, Eloise M. Walker
Publikováno v:
Open Biology, Vol 7, Iss 12 (2017)
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a chang
Externí odkaz:
https://doaj.org/article/18f7548d2de1411f809790675d5bf748
Autor:
Jeong Joo Kim, Christian Flueck, Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David A Baker, Friedrich W Herberg, Choel Kim
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004639 (2015)
The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG's activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functions
Externí odkaz:
https://doaj.org/article/cdf948dfee564831ba47e158adaa23ca
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48206 (2012)
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of
Externí odkaz:
https://doaj.org/article/8d51aadaab954381bf6d54de296d29c6