Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christian Fetzer"'
Publikováno v:
RSC Chemical Biology. 3:955-971
Unlike most bacteria, L. monocytogenes encodes 2 isoforms of Caseinolytic Protease P. Balogh et al. show that both proteins form a heterocomplex temperature-dependently and find protein substrate candidates with an integrated proteomic approach.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379d3c53a6a6e7d1d9f8ab75c9759ba5
https://doi.org/10.1039/d2cb00077f
https://doi.org/10.1039/d2cb00077f
Publikováno v:
Journal of Proteome Research. 20:867-879
Staphylococcus aureus represents an opportunistic pathogen, which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd90120efdeeb9200c0952365c27764d
https://doi.org/10.1021/acs.jproteome.0c00668
https://doi.org/10.1021/acs.jproteome.0c00668
Autor:
Stephan A. Sieber, Manfred Rohde, Mathias W. Hackl, Eva Medina, Vadim S. Korotkov, Elena Kunold, Franziska A. Mandl, William M. Wuest, Christian Fetzer, Robert Macsics, Philipp Le, Maria Reinecke, Bernhard Kuster, Johannes Lehmann, Diego Chaves-Moreno, Katharina Rox, Stephan M. Hacker, Dietmar H. Pieper, Iris Antes, Megan C. Jennings, Ilke Ugur
Publikováno v:
Nature chemistry
International
United States
England
International
United States
England
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935e55da529e0b968c01c74f13b95bcd
http://europepmc.org/articles/PMC6994260
http://europepmc.org/articles/PMC6994260
Publikováno v:
Journal of proteome research. 20(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfb761a80c4280ad12b2e371bd0503cb
https://pubmed.ncbi.nlm.nih.gov/33210542
https://pubmed.ncbi.nlm.nih.gov/33210542
Autor:
Dietrich Mostert, Jennifer K. Bender, Franziska Layer, Mathias W. Hackl, Robert Macsics, Christian Fetzer, Stephan A. Sieber
Publikováno v:
Applied and environmental microbiology
United States
Appl Environ Microbiol
United States
Appl Environ Microbiol
Triclocarban (TCC), a formerly used disinfectant, kills bacteria via an unknown mechanism of action. A structural hallmark is its N,N′-diaryl urea motif, which is also present in other antibiotics, including the recently reported small molecule PK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a5cdb2bd28e431927159f619cc1197
https://hdl.handle.net/10033/622441
https://hdl.handle.net/10033/622441
Autor:
William M. Wuest, Paul Stodghill, Stephan A. Sieber, Colleen E. Keohane, Andrew D. Steele, Christian Fetzer, Melanie J. Filiatrault, Krista M Giglio
Publikováno v:
ACS Infectious Diseases. 4:1179-1187
Promysalin, a secondary metabolite produced by P. putida RW10S1, is a narrow-spectrum antibiotic that targets P. aeruginosa over other Pseudomonas spp. P. putida KT2440, a nonproducing strain, displays increased swarming motility and decreased pyover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c690f692348378be37373569944e0499
https://doi.org/10.1021/acsinfecdis.8b00041
https://doi.org/10.1021/acsinfecdis.8b00041
Autor:
Stephan A. Sieber, Martin Neuenschwander, Christian Fetzer, Robert Thänert, Jens Peter von Kries, Eva Medina, Kyu Myung Lee, Vadim S. Korotkov
Publikováno v:
Angewandte Chemie. 129:15952-15957
Die ClpXP-Protease von Staphylococcus aureus ist ein wichtiger Regulator der Zellhomoostase und Virulenz. Mithilfe eines Hochdurchsatz-Screenings gegen den ClpXP-Komplex wurde ein spezifischer Inhibitor des ClpX-Chaperons identifiziert, der den oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bf335ee6a617ec6d9b755dcbcc28b8
https://doi.org/10.1002/ange.201708454
https://doi.org/10.1002/ange.201708454
Publikováno v:
Organic & biomolecular chemistry
Proteolysis mediated by ClpXP is a crucial cellular process linked to bacterial pathogenesis. The development of specific inhibitors has largely focused on ClpP. However, this focus was challenged by a recent finding showing that conformational contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aef918aac3b99157b398c0494ad14df
https://pubmed.ncbi.nlm.nih.gov/31313793
https://pubmed.ncbi.nlm.nih.gov/31313793
Autor:
Franziska A. Mandl, Stephan A. Sieber, Klaus Richter, Ilke Ugur, Christian Fetzer, Iris Antes, Jan Vomacka, Volker C. Kirsch, Thilo M. Fuchs, Sabine Schneider, Elena Kunold
Publikováno v:
Angewandte Chemie International Edition. 55:14852-14857
Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0e474daf8a9f18eeed262005952659
https://doi.org/10.1002/anie.201607338
https://doi.org/10.1002/anie.201607338
Autor:
Elena Kunold, Klaus Richter, Ilke Ugur, Iris Antes, Jan Vomacka, Volker C. Kirsch, Stephan A. Sieber, Franziska A. Mandl, Thilo M. Fuchs, Christian Fetzer, Sabine Schneider
Publikováno v:
Angewandte Chemie. 128:15074-15079
Aufgrund ihrer undurchlassigeren Zellmembran und der damit verbundenen eingeschrankten Aufnahme von niedermolekularen Verbindungen stellen Gram-negative Bakterien eine grose Herausforderung fur die Entwicklung neuer Antibiotika dar. Hier wurden natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::628a02cb5640cb885d3d51218cb047f8
https://doi.org/10.1002/ange.201607338
https://doi.org/10.1002/ange.201607338