Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Christian Faul"'
Autor:
Kylie Heitman, Seth Bollenbecker, Jordan Bradley, Brian Czaya, Abul Fajol, Sarah Madison Thomas, Qing Li, Svetlana Komarova, Stefanie Krick, Glenn C. Rowe, Matthew S. Alexander, Christian Faul
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9308 (2024)
Chronic kidney disease (CKD) is associated with various pathologic changes, including elevations in serum phosphate levels (hyperphosphatemia), vascular calcification, and skeletal muscle atrophy. Elevated phosphate can damage vascular smooth muscle
Externí odkaz:
https://doaj.org/article/35883c1fb1e142d9a97860fc3f330b5d
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5117 (2024)
Chronic kidney disease (CKD) is associated with significant reductions in lean body mass and in the mass of various tissues, including skeletal muscle, which causes fatigue and contributes to high mortality rates. In CKD, the cellular protein turnove
Externí odkaz:
https://doaj.org/article/906c4daa097d4c529a480ba93cf95593
Autor:
Seth Bollenbecker, Kylie Heitman, Brian Czaya, Molly Easter, Meghan June Hirsch, Shia Vang, Elex Harris, E. Scott Helton, Jarrod W. Barnes, Christian Faul, Stefanie Krick
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract An elevation in serum phosphate—also called hyperphosphatemia—is associated with reduced kidney function in chronic kidney disease (CKD). Reports show CKD patients are more likely to develop lung disease and have poorer kidney function t
Externí odkaz:
https://doaj.org/article/db07b6064cd94c5c8b00468b53f06677
Autor:
Thomas M. Berghaus, Stefanie Bader, Christian Faul, Sabine Haberl, Florian Schwarz, Alessandro Liebich, Alexander Dierks, Malte Kircher, Constantin Lapa, Christian H. Pfob
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-6 (2022)
Abstract Background Anticoagulant treatment is recommended for at least three months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related acute pulmonary embolism (PE), but the persistent pulmonary clot burden after that time is
Externí odkaz:
https://doaj.org/article/5107dc7732914379b1410e30b2194ecf
Autor:
Tarak Srivastava, Katherine M. Dell, Kevin V. Lemley, Debbie S. Gipson, Frederick J. Kaskel, Kevin Edward Meyers, Christian Faul, Ayelet Goldhaber, LauraJane Pehrson, Howard Trachtman
Publikováno v:
Glomerular Diseases, Pp 1-8 (2022)
Introduction: Minimal change disease in childhood can follow a frequently relapsing or steroid-dependent course in up to 40% of cases. Second-line immunosuppressive medications that are used to manage these patients are associated with significant ad
Externí odkaz:
https://doaj.org/article/47cf391d09624317bd22d0ca8697b20f
Autor:
Christopher Yanucil, Dominik Kentrup, Xueyi Li, Alexander Grabner, Karla Schramm, Eliana C. Martinez, Jinliang Li, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Adam R. Wende, Alexis Sloan, Johanna M. Roche, Alessia Fornoni, Michael S. Kapiloff, Christian Faul
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Fibroblast growth factor (FGF) 21, a hormone that increases insulin sensitivity, has shown promise as a therapeutic agent to improve metabolic dysregulation. Here we report that FGF21 directly targets cardiac myocytes by binding β-klotho an
Externí odkaz:
https://doaj.org/article/fe47b8724d4d4d738d8504c6ebbc913e
Autor:
Ying Si, Mohamed Kazamel, Michael Benatar, Joanne Wuu, Yuri Kwon, Thaddaeus Kwan, Nan Jiang, Dominik Kentrup, Christian Faul, Lyndsy Alesce, Peter H. King
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness. Skeletal muscle is a prime source for biomarker discovery since it is one of the earliest sites to manifest disease pathol
Externí odkaz:
https://doaj.org/article/0f8008a5ad874d87a61a78f2f91ba8e9
Autor:
Brian Czaya, Kylie Heitman, Isaac Campos, Christopher Yanucil, Dominik Kentrup, David Westbrook, Orlando Gutierrez, Jodie L Babitt, Grace Jung, Isidro B Salusky, Mark Hanudel, Christian Faul
Publikováno v:
eLife, Vol 11 (2022)
Elevations in plasma phosphate concentrations (hyperphosphatemia) occur in chronic kidney disease (CKD), in certain genetic disorders, and following the intake of a phosphate-rich diet. Whether hyperphosphatemia and/or associated changes in metabolic
Externí odkaz:
https://doaj.org/article/81f9c42874cc4914b1511f208920ae5e
Autor:
Seth Bollenbecker, Molly Easter, Shia Vang, Meghan Hirsch, Jarrod Barnes, Christian Faul, Stefanie Krick
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 83-83 (2022)
OBJECTIVES/GOALS: Using a cell culture model, we will determine the effects of phosphate on primary lung cell cultures and use our results to delineate a pathway through which these changes are carried out. Using animal models, we will determine the
Externí odkaz:
https://doaj.org/article/35eb8189bad34b019ca6e27c6e173f50
Autor:
Molly Easter, Jaleesa Garth, Elex S. Harris, Ren-Jay Shei, Eric S. Helton, Yuhua Wei, Rebecca Denson, Rennan Zaharias, Steven M. Rowe, Patrick Geraghty, Christian Faul, Jarrod W. Barnes, Stefanie Krick
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Fibroblast growth factor receptor (FGFR) 4 has been shown to mediate pro-inflammatory signaling in the liver and airway epithelium in chronic obstructive pulmonary disease. In past reports, FGFR4 knockout (Fgfr4−/−) mice did not show any lung phe
Externí odkaz:
https://doaj.org/article/ca2d7e1e16c8482e9bb9e93b4943e9c8