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pro vyhledávání: '"Christian Fauchard"'
Autor:
Daniel Galtier, Jean Benoit, Remy Guegan, Joseph Millan, Jacques Clement, Michel Beaumont, Michel Vedel, Joseph Diaz, Claude Muneaux, Robert Schwyzer, Christian Fauchard, Yvette Muneaux
Publikováno v:
Bioorganic Chemistry. 8:429-442
A large-scale synthesis of somatostatin was developed. A stepwise C → N approach in solution was used, employing N (α)-t-butoxycarbonyl amino acid active esters. The scheme of semipermanent protection utilized 2-(methylsulfonyl)-ethoxycarbonyl for