Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christian F, Krebs"'
Autor:
Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges, Melanie Janning
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yie
Externí odkaz:
https://doaj.org/article/2c341ef7571b4502937a3beb26a74b4b
Autor:
Ann-Christin Gnirck, Marie-Sophie Philipp, Alex Waterhölter, Malte Wunderlich, Nikhat Shaikh, Virginia Adamiak, Lena Henneken, Tobias Kautz, Tingting Xiong, Daniela Klaus, Pascal Tomczyk, Mohamad M. Al-Bahra, Dirk Menche, Mark Walkenhorst, Olivier Lantz, Anne Willing, Manuel A. Friese, Tobias B. Huber, Christian F. Krebs, Ulf Panzer, Christian Kurts, Jan-Eric Turner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory diseases of barrier organs, but so far, their role in kidney disease is unclear. Here we report that MAIT cells that recognize their prototypical ligand
Externí odkaz:
https://doaj.org/article/ea197fd8a59e40e69a85f91fdcdab807
Autor:
Benjamin Grünhagel, Malte Borggrewe, Sven Hendrik Hagen, Susanne M. Ziegler, Florian Henseling, Laura Glau, Rebecca-Jo Thiele, Maria Pujantell, Varshi Sivayoganathan, Benedetta Padoan, Janna M. Claussen, Arne Düsedau, Jana Hennesen, Madeleine J. Bunders, Stefan Bonn, Eva Tolosa, Christian F. Krebs, Christoph Dorn, Marcus Altfeld
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108209- (2023)
Summary: Type I interferons (IFN-I) are important mediators of antiviral immunity and autoimmune diseases. Female plasmacytoid dendritic cells (pDCs) exert an elevated capacity to produce IFN-I upon toll-like receptor 7 (TLR7) activation compared to
Externí odkaz:
https://doaj.org/article/3e9659bff4ad40d09be5365c3478f73a
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Autor:
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M. Tomas, Elion Hoxha, Ulrich O. Wenzel, Tobias B. Huber, Thorsten Wiech, Jan-Eric Turner, Christian F. Krebs, Ulf Panzer
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Glucocorticoids remain a cornerstone of therapeutic regimes for autoimmune and chronic inflammatory diseases — for example, in different forms of crescentic glomerulonephritis — because of their rapid antiinflammatory effects, low cost, and wide
Externí odkaz:
https://doaj.org/article/6443c52a90ff43ecadb3bda903f06ac0
Autor:
Tilman Schmidt, Sara Afonso, Luce Perie, Karin Heidenreich, Sonia Wulf, Christian F. Krebs, Peter F. Zipfel, Thorsten Wiech
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the re-classification of membranoproliferative glomerulonephritis the new disease entity C3 glomerulopathy is diagnosed if C3 deposition is clearly dominant over immunoglobulins in immunohistochemistry or immunofluorescence. Although this new d
Externí odkaz:
https://doaj.org/article/790b4967f01b4ebab91eca8d0437d45e
Autor:
Patricia Bartsch, Christoph Kilian, Malte Hellmig, Hans-Joachim Paust, Alina Borchers, Amirrtavarshni Sivayoganathan, Leon Enk, Yu Zhao, Nikhat Shaikh, Henning Büttner, Milagros N Wong, Victor G Puelles, Thorsten Wiech, Richard Flavell, Tobias B Huber, Jan-Eric Turner, Stefan Bonn, Samuel Huber, Nicola Gagliani, Hans-Willi Mittrücker, Holger Rohde, Ulf Panzer, Christian F Krebs
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010430 (2022)
Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis. In part
Externí odkaz:
https://doaj.org/article/380fd4269d2449729d87e44af873b2c2
Autor:
Mohamed Marouf, Pierre Machart, Vikas Bansal, Christoph Kilian, Daniel S. Magruder, Christian F. Krebs, Stefan Bonn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Low sample numbers often limit the robustness of analyses in biomedical research. Here, the authors introduce a method to generate realistic scRNA-seq data using GANs that learn gene expression dependencies from complex samples, and show that augment
Externí odkaz:
https://doaj.org/article/54eea9701f364c569d5dd410717e6a68
Autor:
Marina Zimmermann, Martin Klaus, Milagros N. Wong, Ann-Katrin Thebille, Lukas Gernhold, Christoph Kuppe, Maurice Halder, Jennifer Kranz, Nicola Wanner, Fabian Braun, Sonia Wulf, Thorsten Wiech, Ulf Panzer, Christian F. Krebs, Elion Hoxha, Rafael Kramann, Tobias B. Huber, Stefan Bonn, Victor G. Puelles
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Morphologic examination of tissue biopsies is essential for histopathological diagnosis. However, accurate and scalable cellular quantification in human samples remains challenging. Here, we present a deep learning–based approach for antigen-specif
Externí odkaz:
https://doaj.org/article/3c08e835153e4f5397578a86dbdc44f5
Autor:
Sven Pischke, Sarah Tamanaei, Maria Mader, Julian Schulze zur Wiesch, Christine Petersen-Benz, Munif Haddad, Marylyn M. Addo, Tilman Schmidt, Tobias B. Huber, Christian F. Krebs, Oliver M. Steinmetz, Jan E. Turner, Elion Hoxha, Thomas Horvatits
Publikováno v:
Pathogens, Vol 11, Iss 1, p 18 (2021)
Among numerous other immune-mediated diseases, glomerulonephritis has also been suspected to be an extrahepatic manifestation of HEV infection. In this prospective study, we tested 108 patients with glomerulonephritis and 108 age- and sex-matched hea
Externí odkaz:
https://doaj.org/article/dbb7081c77ac4069acc53f6fd4d5300c