Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Christian Ehnholm"'
Autor:
Ilenia Minicocci, Anna Tikka, Eleonora Poggiogalle, Jari Metso, Anna Montali, Fabrizio Ceci, Giancarlo Labbadia, Mario Fontana, Alessia Di Costanzo, Marianna Maranghi, Aldo Rosano, Christian Ehnholm, Lorenzo Maria Donini, Matti Jauhiainen, Marcello Arca
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 1097-1107 (2016)
The consequences of angiopoietin-like protein 3 (ANGPTL3) deficiency on postprandial lipid and lipoprotein metabolism has not been investigated in humans. We studied 7 homozygous (undetectable circulating ANGPTL3 levels) and 31 heterozygous (50% of c
Externí odkaz:
https://doaj.org/article/e3b959eb3eb143e98fb585b680745bdf
Autor:
Pietari Ripatti, Joel T Rämö, Sanni Söderlund, Ida Surakka, Niina Matikainen, Matti Pirinen, Päivi Pajukanta, Antti-Pekka Sarin, Susan K Service, Pirkka-Pekka Laurila, Christian Ehnholm, Veikko Salomaa, Richard K Wilson, Aarno Palotie, Nelson B Freimer, Marja-Riitta Taskinen, Samuli Ripatti
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006078 (2016)
Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease. The genetic architecture and contribution
Externí odkaz:
https://doaj.org/article/5198904350ad46738f987120e6f61325
Autor:
Marius R. Robciuc, Jussi Naukkarinen, Alfredo Ortega-Alonso, Henna Tyynismaa, Taneli Raivio, Aila Rissanen, Jaakko Kaprio, Christian Ehnholm, Matti Jauhiainen, Kirsi H. Pietiläinen
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1575-1582 (2011)
Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associat
Externí odkaz:
https://doaj.org/article/5a0474069e9a4871b51c3961040d73ad
Autor:
Dana Bailey, Isabelle Ruel, Anouar Hafiane, Haley Cochrane, Iulia Iatan, Matti Jauhiainen, Christian Ehnholm, Larbi Krimbou, Jacques Genest
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 785-797 (2010)
The specifics of nascent HDL remodeling within the plasma compartment remain poorly understood. We developed an in vitro assay to monitor the lipid transfer between model nascent HDL (LpA-I) and plasma lipoproteins. Incubation of α-125I-LpA-I with p
Externí odkaz:
https://doaj.org/article/678f2e7782d646f78abdaef28dd86e7a
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 824-831 (2010)
We have developed and validated quantitative ELISAs for human angiopoietin-like (ANGPTL)3 and 4 and correlated their serum levels with parameters of lipid and carbohydrate metabolism. For this study, we used a random subsample of the Health 2000 Heal
Externí odkaz:
https://doaj.org/article/66953a9d89cc42b1ab74d326b7c50b60
Autor:
Shuhei Nakanishi, Riikka Vikstedt, Sanni Söderlund, Miriam Lee-Rueckert, Anne Hiukka, Christian Ehnholm, Mikko Muilu, Jari Metso, Jussi Naukkarinen, Leena Palotie, Petri T. Kovanen, Matti Jauhiainen, Marja-Riitta Taskinen
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 183-192 (2009)
The main antiatherogenic function of HDL is to promote the efflux of cholesterol from peripheral cells and transport it to the liver for excretion in a process termed reverse cholesterol transport. The aim of this study was to evaluate the cholestero
Externí odkaz:
https://doaj.org/article/70430b0ac3304cfbaaca2c33689b2de1
Autor:
Josefin Ahnström, Olof Axler, Matti Jauhiainen, Veikko Salomaa, Aki S. Havulinna, Christian Ehnholm, Ruth Frikke-Schmidt, Anne Tybjærg-Hansen, Björn Dahlbäck
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 9, Pp 1912-1917 (2008)
Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-β-HDL and to increase cholesterol efflux f
Externí odkaz:
https://doaj.org/article/bfc4dc6172cd4fac9e57e8ded2e3bcb7
Autor:
Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Christian Ehnholm, Petri T. Kovanen, Matti Jauhiainen
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 8, Pp 1725-1732 (2006)
In vitro experiments have demonstrated that exogenous phospholipid transfer protein (PLTP), i.e. purified PLTP added to macrophage cultures, influences ABCA1-mediated cholesterol efflux from macrophages to HDL. To investigate whether PLTP produced by
Externí odkaz:
https://doaj.org/article/4f22c10713794c82a50d8849159b56ca
Autor:
Sanni Söderlund, Aino Soro-Paavonen, Christian Ehnholm, Matti Jauhiainen, Marja-Riitta Taskinen
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 8, Pp 1643-1651 (2005)
Preβ-HDL particles act as the primary acceptors of cellular cholesterol in reverse cholesterol transport (RCT). An impairment of RCT may be the reason for the increased risk of coronary heart disease (CHD) in subjects with familial low HDL. We studi
Externí odkaz:
https://doaj.org/article/7e18343232784993b816017267b3bb4d
Autor:
Minna T. Jänis, Sarah Siggins, Esa Tahvanainen, Riikka Vikstedt, Kaisa Silander, Jari Metso, Arpo Aromaa, Marja-Riitta Taskinen, Vesa M. Olkkonen, Matti Jauhiainen, Christian Ehnholm
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2303-2309 (2004)
Human serum phospholipid transfer protein (PLTP) exists as a catalytically active (HA-PLTP) and a low-active (LA-PLTP) form. In this study, the association of PLTP activity and the concentrations of both forms with lipid and carbohydrate parameters w
Externí odkaz:
https://doaj.org/article/84323361fc6148cb80067780a1ef0fff