Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christian E. Stieger"'
Autor:
Jacob L. Gorenflos López, Peter Schmieder, Kristin Kemnitz-Hassanin, Hatice Ceyda Asikoglu, Arif Celik, Christian E. Stieger, Dorothea Fiedler, Stephan Hinderlich, Christian P. R. Hackenberger
Publikováno v:
Chemical Science. 14:3482-3492
From chemical shifts to conversion velocity: real-time NMR spectroscopy using a combination of 1D and 2D experiments can monitor individual enzymatic steps in the sialic acid biosynthesis pathway in rat liver cytosolic extract.
Autor:
Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie. 134
Autor:
Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie International Edition. 61
Autor:
Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Wir berichten über eine Dichtefunktionaltheorie (DFT)-basierte Entdeckung von Ethinyl-Triazolyl-Phosphinaten (ETP) als eine neue Klasse elektrophiler Verbindungen für die selektive Biokonjugation von Cystein. Mit Hilfe der CuI-katalysierten Azid-Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44ed6814ba0b83c7ee26653407e7f37
Publikováno v:
Angewandte Chemie (International Ed. in English)
Diethynyl phosphinates were developed as bisfunctional electrophiles for the site‐selective modification of peptides, proteins and antibodies. One of their electron‐deficient triple bonds reacts selectively with a thiol and positions an electroph
Publikováno v:
Angewandte Chemie. 133:15487-15492
Autor:
Georg J. Pirklbauer, Christian E. Stieger, Stephan M. Winkler, Karl Mechtler, Viktoria Dorfer, Manuel Matzinger
Publikováno v:
Journal of Proteome Research
Cross-linking mass spectrometry (XL-MS) has become a powerful technique that enables insights into protein structures and protein interactions. The development of cleavable cross-linkers has further promoted XL-MS through search space reduction, ther
Autor:
Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Publikováno v:
Angewandte Chemie (International ed. in English). 61(41)
We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective bioconjugation. By using CuI‐catalysed azide alkyne cycloaddition (CuAAC) in
Publikováno v:
Total Chemical Synthesis of Proteins
Autor:
Alice L. Baumann, Nils Trieloff, Kristin Kemnitz-Hassanin, Christian E. Stieger, Sergej Schwagerus, Christian P. R. Hackenberger, Kevin Broi, Peter Schmieder
Publikováno v:
Journal of the American Chemical Society. 142:9544-9552
Herein we introduce vinylphosphonothiolates as a new class of cysteine-selective electrophiles for protein labeling and the formation of stable protein-protein conjugates. We developed a straightforward synthetic route to convert nucleophilic thiols