Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Christian E. Stieger"'
1
Real-time monitoring of the sialic acid biosynthesis pathway by NMR
Autor: Jacob L. Gorenflos López, Peter Schmieder, Kristin Kemnitz-Hassanin, Hatice Ceyda Asikoglu, Arif Celik, Christian E. Stieger, Dorothea Fiedler, Stephan Hinderlich, Christian P. R. Hackenberger
Publikováno v: Chemical Science. 14:3482-3492
From chemical shifts to conversion velocity: real-time NMR spectroscopy using a combination of 1D and 2D experiments can monitor individual enzymatic steps in the sialic acid biosynthesis pathway in rat liver cytosolic extract.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d424d04c5a4a7e5c832a81b7d881fe8
https://doi.org/10.1039/d2sc06986e
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4
Diethynyl Phosphinates for Cysteine‐Selective Protein Labeling and Disulfide Rebridging
Autor: Frieder Körlin, Christian P. R. Hackenberger, Luise Franz, Christian E. Stieger
Publikováno v: Angewandte Chemie (International Ed. in English)
Diethynyl phosphinates were developed as bisfunctional electrophiles for the site‐selective modification of peptides, proteins and antibodies. One of their electron‐deficient triple bonds reacts selectively with a thiol and positions an electroph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fd43edc280709ce18f5a1a90a39559
https://doi.org/10.1002/anie.202100683
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7
MS Annika: A New Cross-Linking Search Engine
Autor: Georg J. Pirklbauer, Christian E. Stieger, Stephan M. Winkler, Karl Mechtler, Viktoria Dorfer, Manuel Matzinger
Publikováno v: Journal of Proteome Research
Cross-linking mass spectrometry (XL-MS) has become a powerful technique that enables insights into protein structures and protein interactions. The development of cleavable cross-linkers has further promoted XL-MS through search space reduction, ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68e254817f4e663bfabfbc2652dac2d
https://doi.org/10.1021/acs.jproteome.0c01000
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9
DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
Autor: Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Publikováno v: Angewandte Chemie (International ed. in English). 61(41)
We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective bioconjugation. By using CuI‐catalysed azide alkyne cycloaddition (CuAAC) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbd48633e348bd025a0f82a98e3249b
https://pubmed.ncbi.nlm.nih.gov/35792701
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10
Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol–Thiol Bioconjugations
Autor: Alice L. Baumann, Nils Trieloff, Kristin Kemnitz-Hassanin, Christian E. Stieger, Sergej Schwagerus, Christian P. R. Hackenberger, Kevin Broi, Peter Schmieder
Publikováno v: Journal of the American Chemical Society. 142:9544-9552
Herein we introduce vinylphosphonothiolates as a new class of cysteine-selective electrophiles for protein labeling and the formation of stable protein-protein conjugates. We developed a straightforward synthetic route to convert nucleophilic thiols
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74180b8e4ef44c56880cbd2e673e81b2
https://doi.org/10.1021/jacs.0c03426
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