Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Christian E. Schafmeister"'
Autor:
Yihui Xie, Danni Luo, Jesse A. Wiener, Alexander B. Koval, Conrad T. Pfeiffer, Christian E. Schafmeister
Publikováno v:
Angewandte Chemie International Edition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f60aabd7beec413142844abf3df058
https://doi.org/10.1002/anie.202302809
https://doi.org/10.1002/anie.202302809
Autor:
Matthew F. D. Hurley, Justin D. Northrup, Vincent A. Voelz, Yunhui Ge, Christian E. Schafmeister
Publikováno v:
J Chem Inf Model
The rational design of foldable and functionalizable peptidomimetic scaffolds requires the concerted application of both computational and experimental methods. Recently, a new class of designed peptoid macrocycle incorporating spiroligomer proline m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa7e1192e59f43d212e936edc75d0d7
https://doi.org/10.1021/acs.jcim.1c00447
https://doi.org/10.1021/acs.jcim.1c00447
Autor:
Justin D. Northrup, Vincent A. Voelz, Richard H. G. Baxter, Christian E. Schafmeister, Michael J. Zdilla, Taylor Keller, Chun-Feng David Hou, Matthew F. D. Hurley, Jesse A Wiener
Publikováno v:
The Journal of organic chemistry. 86(6)
Herein, we introduce the efficient synthesis of Q-proline (Q-Pro) based, metal-binding macrocycles (QPM), which can display up to nine functional groups. Synthesis of eight QPM was achieved through standard Fmoc-SPPS and peptoid chemistry. QPM are di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492c3828cf74406b8bf2372ec1e2e4e4
https://pubmed.ncbi.nlm.nih.gov/33635647
https://pubmed.ncbi.nlm.nih.gov/33635647
Autor:
Zachary Z Brown, Kavitha Akula, Alla Arzumanyan, Jennifer Alleva, Marcus Jackson, Eugeney Bichenkov, Joel B Sheffield, Mark A Feitelson, Christian E Schafmeister
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45948 (2012)
We demonstrate functionalized spiroligomers that mimic the HDM2-bound conformation of the p53 activation domain. Spiroligomers are stereochemically defined, functionalized, spirocyclic monomers coupled through pairs of amide bonds to create spiro-lad
Externí odkaz:
https://doaj.org/article/bf935dddc2744099b5b565667ce91045
Autor:
Conrad T. Pfeiffer, Jae Eun Cheong, Justin D. Northrup, Matthew F.L. Parker, Melody A. Pham, Christian E. Schafmeister
Publikováno v:
Tetrahedron Letters. 59:2884-2888
Spiroligomers are a class of peptidomimetics that connect interchangeable, stereochemically pure, cyclic monomers through pairs of amide bonds to form diketopiperazines between the monomers. This enables them to adopt predictable and programmable str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795eb7e22e84dd435b8048dab1cd3f9d
https://doi.org/10.1016/j.tetlet.2018.05.041
https://doi.org/10.1016/j.tetlet.2018.05.041
Publikováno v:
The Journal of Organic Chemistry. 80:8968-8978
We demonstrate the synthesis and characterization of the solution conformations of a collection of functionalized spiroligomer-based macrocycles. These macrocycles contain 14 independently controllable stereocenters and four independently controllabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c397ae262d3f0a55d60f1de1eb5da6b1
https://doi.org/10.1021/acs.joc.5b01109
https://doi.org/10.1021/acs.joc.5b01109
Autor:
Justin D. Northrup, Conrad T. Pfeiffer, Matthew F.L. Parker, Jae Eun Cheong, Christian E. Schafmeister
Publikováno v:
Tetrahedron Letters. 57:4882-4884
trans-4-Hydroxy-l-proline derived bis-amino acids are chiral, cyclic building blocks that display two alpha-amino acids that are differentiated from each other with protecting groups. They are assembled into spiroligomers—rigid, shape-programmable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f544b7a8fec6f6c9b167da7bcafd8b
https://doi.org/10.1016/j.tetlet.2016.09.032
https://doi.org/10.1016/j.tetlet.2016.09.032
Publikováno v:
The Journal of organic chemistry. 82(24)
Creating functional macromolecules that possess the diversity and functionality of proteins poses an enormous challenge, as this requires large, preorganized macromolecules to facilitate interactions. Peptoids have been shown to interact with protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a0851f445f5ee76c8272c79821b146
https://pubmed.ncbi.nlm.nih.gov/29161507
https://pubmed.ncbi.nlm.nih.gov/29161507
Autor:
Paul M. Flanigan, Robert J. Levis, Christian E. Schafmeister, Conrad T. Pfeiffer, Santosh Karki, Johnny J. Perez, Fengjian Shi
Publikováno v:
Journal of the American Society for Mass Spectrometry. 25:1572-1582
The internal energy distributions for dried and liquid samples that were vaporized with femtosecond duration laser pulses centered at 800 nm and postionized by electrospray ionization-mass spectrometry (LEMS) were measured and compared with conventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdab9e7f7277861a876f31b58571aea8
https://doi.org/10.1007/s13361-014-0936-6
https://doi.org/10.1007/s13361-014-0936-6
Autor:
Matthew F.L. Parker, Michael J. Zdilla, Shivaiah Vaddypally, Kendall N. Houk, Guillaume Bollot, Christian E. Schafmeister, Sílvia Osuna
Publikováno v:
Journal of the American Chemical Society, vol 136, iss 10
Journal of the American Chemical Society
Journal of the American Chemical Society
A series of hydrogen-bonding catalysts have been designed for the aromatic Claisen rearrangement of a 1,1-dimethylallyl coumarin. These catalysts were designed as mimics of the two-point hydrogen-bonding interaction present in ketosteroid isomerase t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d82ccc6e488bd227c0c77e1e5b14f7f
https://doi.org/10.1021/ja409214c
https://doi.org/10.1021/ja409214c