Výsledky vyhledávání - "Christian E. Argueta"

RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression

Autor: Christian E. Argueta, Christopher Figy, Sawssen Bouali, Anna Guo, Kam C. Yeung, Gabriel Fenteany

Publikováno v: J Biol Chem

Raf kinase inhibitor protein (RKIP) is a multifunctional modulator of intracellular signal transduction. Although most of its functions have been considered cytosolic, we show here that the localization of RKIP is primarily nuclear in both growing an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b119fc35d841a95c4b3d379070bf02
https://doi.org/10.1016/j.jbc.2023.103023

Zobrazit plný text záznamu

Akademický článek

Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.

Autor: David A Knecht, Rebecca A LaFleur, Alem W Kahsai, Christian E Argueta, Anwar B Beshir, Gabriel Fenteany

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14039 (2010)

Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism. They are also known to cause changes in the organization of the

Externí odkaz: https://doaj.org/article/70c4fe0d9283497bbc5fc0cee1a22462

Zobrazit plný text záznamu

Diversity Through a Branched Reaction Pathway: Generation of Multicyclic Scaffolds and Identification of Antimigratory Agents

Autor: Ohyun Kwon, Sabrina Castellano, Gabriel Fenteany, Sape S. Kinderman, Zhiming Wang, Anwar B. Beshir, Christian E. Argueta

Publikováno v: Chemistry: A European Journal, 17(2), 649-654. Wiley-VCH Verlag

A library of 91 heterocyclic compounds composed of 16 distinct scaffolds has been synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis. This effort in div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dde39a6245463b37e2d586326437569
https://doi.org/10.1002/chem.201002195

Zobrazit plný text záznamu

Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket

Autor: Lochana C. Menikarachchi, José A. Gascón, Anwar B. Beshir, Gabriel Fenteany, Christian E. Argueta

Raf kinase inhibitor protein (RKIP) interacts with a number of different proteins and regulates multiple signaling pathways. Here, we show that locostatin, a small molecule that covalently binds RKIP, not only disrupts interactions of RKIP with Raf-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca0eb171fb765326cdd6300a42d8ecb
https://europepmc.org/articles/PMC3121171/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání