Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christian Dombrowski"'
Autor:
Jonathan D. Finn, Amy Rhoden Smith, Mihir C. Patel, Lucinda Shaw, Madeleine R. Youniss, Jane van Heteren, Tanner Dirstine, Corey Ciullo, Reynald Lescarbeau, Jessica Seitzer, Ruchi R. Shah, Aalok Shah, Dandan Ling, Jacqueline Growe, Melissa Pink, Ellen Rohde, Kristy M. Wood, William E. Salomon, William F. Harrington, Christian Dombrowski, Walter R. Strapps, Yong Chang, David V. Morrissey
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://doaj.org/article/f557a3a18840449b89062013d6e1f3ec
Autor:
Wood Kristy M, Corey Ciullo, William Salomon, Finn Jonathan Douglas, Amy Madison Rhoden Smith, Jacqueline Growe, Dandan Ling, Reynald Lescarbeau, Youniss Madeleine, David V. Morrissey, Jessica Seitzer, Ellen Rohde, Tanner Dirstine, Ruchi Rudraprasad Shah, Lucinda Shaw, Melissa Pink, Mihir Patel, Christian Dombrowski, Chang Yong, Jane van Heteren, Aalok Shah, William F. Harrington, Walter Strapps
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Autor:
Drew M. Titmarsh, Andre J. van Wijnen, Wanjin Hong, Emily T. Camilleri, Ren Jie Chua, Torben Helledie, Ian Lee, Ling Ling, Rebekah M. Samsonraj, David A. Rider, James Hoi Po Hui, Christian Dombrowski, Victor Nurcombe, Simon M. Cool, Mario Galindo, Oliver Dreesen
Publikováno v:
Gene. 576:292-303
Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism invokes many adverse systemic events including thrombocytopenia, vascular reactions and osteoporosis. Here, we addressed whether adverse effects might also be dir
Autor:
Saminathan S. Nathan, Bina Rai, James Hoi Po Hui, J.L.J. Lee, Diah S. Bramono, Victor Nurcombe, Hee-Kit Wong, Ling Ling, Sadasivam Murali, Simon M. Cool, Christian Dombrowski, Simon F.R. Hinkley, Zophia X.H. Lim, Tracey J. Bell
Publikováno v:
Biomaterials. 34:5594-5605
Bone morphogenetic protein (BMP)-2 is a potent bone healing compound produced at sites of bone trauma. Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2 by delivery of an affinity-matched heparan sulfate (H
Publikováno v:
SRDS
Recently, the wireless networking community is getting more and more interested in novel protocol designs for safety-critical applications. These new applications come with unprecedented latency and reliability constraints which poses many open chall
Publikováno v:
WoWMoM
The proliferation of wireless communications has lead to a high interest to establish this technology in industrial settings. The main arguments in favor of wireless are reduced costs in deployment and maintenance, as well as increased flexibility. I
Autor:
Andre J. van Wijnen, Wanjin Hong, Christian Dombrowski, Simon M. Cool, Victor Nurcombe, Gary S. Stein, Bina Rai, Zophia X.H. Lim, James Hoi Po Hui, David A. Rider, Ian Lee Hock Hin, Torben Helledie
Publikováno v:
Stem Cells and Development. 21:1897-1910
Insufficient cell number hampers therapies utilizing adult human mesenchymal stem cells (hMSCs) and current ex vivo expansion strategies lead to a loss of multipotentiality. Here we show that supplementation with an embryonic form of heparan sulfate
Autor:
David Tai Leong, David A. Rider, Amber A. Sawyer, Victor Nurcombe, Christian Dombrowski, Grace H. B. Ng, Simon M. Cool, Dietmar W. Hutmacher
Publikováno v:
Stem Cells
Multipotent mesenchymal stem cells (MSCs), first identified in the bone marrow, have subsequently been found in many other tissues, including fat, cartilage, muscle, and bone. Adipose tissue has been identified as an alternative to bone marrow as a s
Publikováno v:
Journal of Molecular Histology. 38:435-447
Several methods to alter cell surface glycosaminoglycan (GAG) expression have previously been described, including treatments with chlorate to reduce the addition of charged sulfate groups, xyloside compounds to displace GAGs from their core proteins
Autor:
Larisa M. Haupt, Simon M. Cool, Torben Helledie, Kee Woei Ng, Tobias Speicher, Victor Nurcombe, Christian Dombrowski
Publikováno v:
Stem Cells and Development
The mechanisms involved in the control of embryonic stem (ES) cell differentiation are yet to be fully elucidated. However, it has become clear that the family of fibroblast growth factors (FGFs) are centrally involved. In this study we examined the