Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christian Dillon"'
Autor:
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Kötzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Böpple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
Publikováno v:
Journal of Medicinal Chemistry. 65:9206-9229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22c0126effbafdbcab44017975b2c5d
https://doi.org/10.1021/acs.jmedchem.2c00403
https://doi.org/10.1021/acs.jmedchem.2c00403
Publikováno v:
International Journal of the Built Environment and Asset Management. 2:132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82681b784fe4025a3523c87377cbc3f3
https://doi.org/10.1504/ijbeam.2021.120483
https://doi.org/10.1504/ijbeam.2021.120483
Publikováno v:
Molecular Cancer Research. 18:A38-A38
The Hippo pathway is not only important for control of organ size in animals, it has also emerged as an important regulator of cancer development and progression. A robust surrogate for pathway activity is of importance to characterize the role of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a363f673567d644b4d212fc32e327a7
https://doi.org/10.1158/1557-3125.hippo19-a38
https://doi.org/10.1158/1557-3125.hippo19-a38
Publikováno v:
SLAS Discovery. 20:305-317
Translating existing and emerging knowledge of cancer biology into effective novel therapies remains a great challenge in drug discovery. A firm understanding of the target biology, confidence in the supporting preclinical research, and access to div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b97268fe7253ac03db07501e4c980d
https://doi.org/10.1177/1087057114564349
https://doi.org/10.1177/1087057114564349
Publikováno v:
International Journal of the Built Environment and Asset Management; 2021, Vol. 2 Issue: 2 p132-161, 30p
Autor:
Mahito Sadaie, Christian Dillon, Masashi Narita, Andrew R. J. Young, Claire J. Cairney, Lauren S. Godwin, Christopher J. Torrance, Dorothy C. Bennett, W. Nicol Keith
Publikováno v:
Molecular Biology of the Cell
Compound screening for altered nuclear phenotypes identifies several promiscuous kinase inhibitors that trigger progression of senescence during a polyploid G1. Their common target is AURKB. More-specific inhibition of AURKB phenocopies these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177765c54f4bb0ab31cb9f10b51ce226
https://eprints.gla.ac.uk/110612/1/110612.pdf
https://eprints.gla.ac.uk/110612/1/110612.pdf
Autor:
Chris D. Madsen, Mark Linch, Asim Khwaja, Nick Peel, Christian Dillon, Peter J. Parker, Julian Downward, Erik Sahai, Marta Sanz-Garcia, Carine Rossé, Jon Roffey, Angus J.M. Cameron, Philippe Riou
Publikováno v:
Carcinogenesis
Summary Atypical PKCι cooperates with oncogenic Ras and Her2, but not all oncogenes, to promote loss of polarized epithelial morphogenesis. Small molecule inhibitors of PKCι can rescue polarized morphology and provide a potential therapeutic strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13696568ae5fbd5a4e071a95b4b9491
https://pubmed.ncbi.nlm.nih.gov/24072773
https://pubmed.ncbi.nlm.nih.gov/24072773
Autor:
Judith Murray-Rust, Brenda Kostelecky, Erika Soriano, Svend Kjaer, Neil Q. McDonald, Sarah Kaye, Bhavisha A Patel, Carine Rossé, Peter J. Parker, Mark Linch, Christelle Soudy, Jon Roffey, Philippe Riou, Caroline Barton, Andrew Purkiss, Phillip P. Knowles, Christian Dillon
Publikováno v:
The Biochemical journal. 451(2)
The aPKC [atypical PKC (protein kinase C)] isoforms ι and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent tumours. To date, few isoform-specific chemical b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9da09319aaf450fea98a3f173e9c6e4
https://pubmed.ncbi.nlm.nih.gov/23418854
https://pubmed.ncbi.nlm.nih.gov/23418854
Autor:
Andrzej Mazan, Naphtali J. Reyna, Faika Mseeh, Christian Dillon, Matthew M. Hamilton, Giulio Draetta, Maria Alimova, Jennifer Bardenhagen, Connor A. Parker, Edward Felix, Phil Jones, Alessia Petrocchi, Carlo Toniatti, Xi Shi, Richard T. Lewis, Joseph R. Marszalek, Elisabetta Leo
Publikováno v:
Molecular Cancer Therapeutics. 14:B48-B48
MTH1 is a protein that sanitizes oxidized dNTPs in the cell. It preferentially hydrolyzes 8-oxo-dGTP and 2-OH-dATP to their corresponding monophosphates and thereby prevents the incorporation of oxidized nucleotides into DNA or RNA. The functional re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::950f397cc413e25497ab1e1dd36c93bd
https://doi.org/10.1158/1535-7163.targ-15-b48
https://doi.org/10.1158/1535-7163.targ-15-b48
Autor:
Peter J. Parker, Philippe Riou, Mark Linch, Neil Q. McDonald, Susan M. Boyd, Christian Dillon, Andrew P. Turnbull, Sven Kjaer, Jon Roffey
Publikováno v:
Cancer Research. 75:LB-052
Protein kinases are attractive targets for pharmacological intervention through their frequent disease associated aberration of cellular signalling networks. In this context an understanding of the myriad of substrates on which a protein kinase opera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379597daa06711e27724cac8c05c4f90
https://doi.org/10.1158/1538-7445.am2015-lb-052
https://doi.org/10.1158/1538-7445.am2015-lb-052