Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christian D. Lates"'
Autor:
Christian D. Lates, Robert Schmouder, Parasar Pal, Olivier J. David, Hisanori Hara, Rhett Behrje
Publikováno v:
Clinical Pharmacology in Drug Development
This open‐label, single‐sequence study in healthy subjects investigated the effects of steady‐state carbamazepine on the pharmacokinetic (PK) profile of a single 2‐mg dose of fingolimod. In period 1, a single oral dose of fingolimod 2 mg (day
Autor:
Samm Portelli, Susan L. Johnson, Omar Abu-Baker, Elizabeth K. Hussey, Michael J. Fossler, William S. Harris, Robert A. Blum, Christian D. Lates, Feng Gao, Elizabeth Gould, Karunakar K. Reddy
Publikováno v:
Clinical pharmacology in drug development. 1(1)
LOVAZA (omega-3-acid ethyl esters; eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]), with diet, lowers very high triglycerides (≥500 mg/dL) in adults. This study evaluated whether an emulsion formulation (LEM) increases the bioavailability o
Autor:
Laurel M. Adams, Lyndon C. Kirby, Robert A. Blum, Christian D. Lates, Derek J. Eberwein, Sharon C. Murray, Ke Zhang, Shannon R. Morris, Brendan M. Johnson
Publikováno v:
The Journal of Clinical Pharmacology. 50:566-575
Casopitant, a novel NK-1 receptor antagonist under investigation for the prevention of postoperative and chemotherapy-induced nausea and vomiting, is a weak to moderate inhibitor of CYP3A and a moderate inducer of CYP2C9 in vitro. Furthermore, both C
Autor:
Michael Hesney, Walter K. Kraft, John Busillo, Kevin M. Gottesdiener, Christian D. Lates, Robert A. Blum, Howard E. Greenberg, Kevin J. Petty, M. Gail Murphy, Scott A. Waldman, Anup K. Majumdar, Sandi Van Buren, Michael R. Goldberg, Laura H. Orlowski, Carolyn M. Hustad, Jacqueline B. McCrea, Deborah Panebianco
Publikováno v:
Clinical Therapeutics. 25:1407-1419
Background: The neurokinin-1-receptor antagonist aprepitant, when given in combination with a corticosteroid and a 5-hydroxytryptamine type 3 (5-HT 3 )-receptor antagonist, has been shown to be effective for the prevention of acute and delated chemot
Publikováno v:
British Journal of Clinical Pharmacology. 53:474-484
Aims Mitogen-induced ex vivo whole blood lymphocyte proliferation (WBLP) is a widely used method to assess lymphocyte responsiveness to immunosuppressive therapy. A three-component complex model was developed to characterize effects of prednisolone o
Autor:
Peter F. Lebowitz, Laurel M. Adams, Christian D. Lates, Ke Zhang, Brendan M. Johnson, Emily Lu, Robert A. Blum
Publikováno v:
Supportive Care in Cancer
Introduction Pharmacokinetic interactions between casopitant (a substrate and weak to moderate inhibitor of CYP3A), dexamethasone (a substrate and weak inducer of CYP3A), and ondansetron (a mixed CYP substrate) were evaluated in a two-part, three-per
Publikováno v:
Journal of clinical pharmacology. 43(11)
The integrity of current corticosteroid dose equivalency tables, as assessed by mechanistic models for cell trafficking and cortisol dynamics, was investigated in this study. Single, presumably equivalent, doses of intravenous hydrocortisone, methylp
Publikováno v:
Clinical pharmacology and therapeutics. 72(4)
Objectives The pharmacokinetics and pharmacodynamics after administration of methylprednisolone alone, diltiazem alone, and both drugs jointly were assessed in healthy volunteers. Methods An unblinded, controlled, fixed-sequence, 2-period study was c
Publikováno v:
Journal of clinical pharmacology. 41(11)
Prednisolone pharmacokinetics (PK) and pharmacyodynamics (PD) were investigated in relation to sex and race in white males, black males, white females, and black females (n = 8/group) after a single oral dose (0.27 mg/kg) of prednisone. The study con