Výsledky vyhledávání - "Christian Czysch"

Akademický článek

Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses

Autor: Judith Stickdorn, Christian Czysch, Carolina Medina-Montano, Lara Stein, Lujuan Xu, Maximilian Scherger, Hansjörg Schild, Stephan Grabbe, Lutz Nuhn

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 20, p 15417 (2023)

For successful therapeutic interventions in cancer immunotherapy, strong antigen-specific immune responses are required. To this end, immunostimulating cues must be combined with antigens to simultaneously arrive at antigen-presenting cells and initi

Externí odkaz: https://doaj.org/article/ca00091d61e74d00b55f95d8fbb79208

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Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels

Publikováno v: Advanced Functional Materials, 32(35):2203490. Wiley-VCH
Advanced Functional Materials

The development of controlled biodegradable materials is of fundamental importance in immunodrug delivery to spatiotemporally controlled immune stimulation but avoid systemic inflammatory side effects. Based on this, polycarbonate nanogels are develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acfb5007876972a84ea63a6bb0c2a2e
https://pure.eur.nl/en/publications/c2730e7e-773c-40fe-a341-123d74664982

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End group dye-labeled polycarbonate block copolymers for micellar (immuno-)drug delivery

Autor: Christian Czysch, Carolina Medina‐Montano, Nils‐Jørgen Knudsen Dal, Thi Dinh, Yannick Fröder, Pia Winterwerber, Konrad Maxeiner, Hans‐Joachim Räder, Detlef Schuppan, Hansjörg Schild, Matthias Bros, Bernhard Biersack, Federico Fenaroli, Stephan Grabbe, Lutz Nuhn

Publikováno v: Macromolecular Rapid Communications

Defined conjugation of functional molecules to block copolymer end groups is a powerful strategy to enhance the scope of micellar carriers for drug delivery. In this study, an approach to access well-defined polycarbonate-based block copolymers by la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790a0f3b72aa3849893d5ecb8718d6e0
http://hdl.handle.net/10852/101556

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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 143(26), 9872-9883. American Chemical Society
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd18e50dbec4b32f50d7dc98705510e
https://hdl.handle.net/21.11116/0000-0008-F185-121.11116/0000-0008-C1FD-1

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Polymerization of long chain alkyl glycidyl ethers: a platform for micellar gels with tailor-made melting points

Autor: Jan Blankenburg, Tobias Johann, Holger Frey, Christian Czysch, Patrick Verkoyen

Publikováno v: Polymer Chemistry. 9:5327-5338

Controlled polymerization of long-chain alkyl glycidyl ethers (AlkGE) under anionic ring opening polymerization conditions is enabled by the addition of a crown ether (18-crown-6, K+). Homopolymers with molecular weights in the range of 4000 to 9000

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::631574c6574b4e1fa578667e79c98904
https://doi.org/10.1039/c8py01312h

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