Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christian Cuba Samaniego"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract A lack of composable and tunable gene regulators has hindered efforts to engineer non-model bacteria and consortia. Toward addressing this, we explore the broad-host potential of small transcription activating RNA (STAR) and propose a design
Externí odkaz:
https://doaj.org/article/e5a0c20c57dc404bb83a26804f555e4c
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105624- (2023)
Summary: Recombinases are site-specific proteins found in nature that are capable of rearranging DNA. This function has made them promising gene editing tools in synthetic biology, as well as key elements in complex artificial gene circuits implement
Externí odkaz:
https://doaj.org/article/7c958cef57fb4a81ad81218a43182b58
Publikováno v:
Journal of Biological Dynamics, Vol 11, Iss 1, Pp 102-120 (2017)
Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computa
Externí odkaz:
https://doaj.org/article/c2662c1ff0344af586a50a5386c5616a
We show how subtraction can be performed via a simple chemical reaction network that includes molecular sequestration. The network computes the difference between the production rate parameters of the two mutually sequestering species. We benefit fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add8332ab45815b4533a13779e7fd14c
https://doi.org/10.1101/2023.04.24.538183
https://doi.org/10.1101/2023.04.24.538183
Autor:
Yichi Zhang, Christian Cuba Samaniego, Katelyn Carleton, Yili Qian, Giulia Giordano, Elisa Franco
Engineered genetic circuits with tailored functions that mimic how cells process information in changing environments (e.g. cell fate decision, chemotaxis, immune response) have great applications in biomedicine and synthetic biology. Although there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592695040abffeeaf3f16132e74f5ff0
https://doi.org/10.1101/2022.04.02.486709
https://doi.org/10.1101/2022.04.02.486709
Publikováno v:
ACS synthetic biology. 11(3)
The lack of signaling modularity of biomolecular systems poses major challenges toward engineering complex networks. Directional signaling between an upstream and a downstream circuit requires the presence of binding events, which result in the consu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed646c7e13daf578912b9013a062e1b8
https://pubmed.ncbi.nlm.nih.gov/35244392
https://pubmed.ncbi.nlm.nih.gov/35244392
Publikováno v:
iScience. 26:105624
In nature, recombinases are site-specific proteins capable of rearranging DNA, and they are expanding the repertoire of gene editing tools used in synthetic biology. The on/off response of recombinases, achieved by inverting the direction of a promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719e5d706d622c708b1c0c3359db730e
https://doi.org/10.1016/j.isci.2022.105624
https://doi.org/10.1016/j.isci.2022.105624
The lack of signalling modularity of biomolecular systems poses major challenges toward engineering complex networks. An important problem is posed by the consumption of signaling molecules upon circuit interconnection, which makes it possible to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f43793565a73d90b60a211a31e44bb
https://doi.org/10.1101/2021.10.26.465912
https://doi.org/10.1101/2021.10.26.465912
Publikováno v:
ACC
Cellular signaling pathways are responsible for decision making that sustains life. Most signaling pathways include post-translational modification cycles, that process multiple inputs and are tightly interconnected. Here we consider a model for phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f7f01a06b0ef835ce0d9b9de2cff0c
https://doi.org/10.23919/acc50511.2021.9482800
https://doi.org/10.23919/acc50511.2021.9482800
Publikováno v:
CDC
Many biological systems need to sense and respond to chemical gradients in order to find nutrients and adapt to their environment. In nature, molecular networks able to compute molecular gradients are complex, making it challenging to build minimal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcbf6f873c61cc8e1fdfc17f1c452992
https://doi.org/10.1109/cdc42340.2020.9304515
https://doi.org/10.1109/cdc42340.2020.9304515