Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Christian Cremer"'
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Akademický článek
Updates in the Development of ImmunoRNases for the Selective Killing of Tumor Cells
Autor: Sandra Jordaan, Olusiji A. Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Publikováno v: Biomedicines, Vol 6, Iss 1, p 28 (2018)
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic pro
Externí odkaz: https://doaj.org/article/66c4f9f9103a4660be7438b5d9de26a3
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2
Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations
Autor: Thomas Nachreiner, Xiaojing Cong, Christian Cremer, Paolo Carloni, Stefan Barth
Publikováno v: Protein Science. 25:1451-1460
Targeted human cytolytic fusion proteins (hCFPs) represent a new generation of immunotoxins (ITs) for the specific targeting and elimination of malignant cell populations. Unlike conventional ITs, hCFPs comprise a human/humanized target cell-specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bfb55f2e4f5931ccfd56606e92a803c
https://doi.org/10.1002/pro.2941
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3
The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia
Autor: Stefan Barth, Theophilus Thepen, Judith Niesen, Fabian Philipp Kreutzer, Edgar Jost, Lea Hein, Christoph Stein, Hannes Brehm, Tim Stroisch, Dmitrij Hristodorov, Radoslav Mladenov, Rainer Fischer, Tim H. Brümmendorf, Christian Cremer, Bernhard Stockmeyer, Tobias Blume
Publikováno v: International Journal of Cancer. 137:2729-2738
Antibody-based immunotherapy of leukemia requires the targeting of specific antigens on the surface of blasts. The Fc gamma receptor (CD64) has been investigated in detail, and CD64-targeting immunotherapy has shown promising efficacy in the targeted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f36a9c929314ac8c7968e471b6e2740
https://doi.org/10.1002/ijc.29628
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4
Angiogenin Mutants as Novel Effector Molecules For the Generation of Fusion Proteins With Increased Cytotoxic Potential
Autor: Thomas Nachreiner, Rainer Fischer, Stefan Barth, Lea Hein, Christian Cremer, Tim Vierbuchen
Publikováno v: Journal of Immunotherapy. 38:85-95
Human cytolytic fusion proteins (hCFPs) are therapeutically efficacious recombinant polypeptides comprising a target cell-specific binding component and a human effector domain that induces apoptosis. Compared with former generations of immunotoxins,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e30e252d040935229b7e3ec289a7a5c
https://doi.org/10.1097/cji.0000000000000053
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6
Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations
Autor: Xiaojing, Cong, Christian, Cremer, Thomas, Nachreiner, Stefan, Barth, Paolo, Carloni
Publikováno v: Protein science : a publication of the Protein Society. 25(8)
Targeted human cytolytic fusion proteins (hCFPs) represent a new generation of immunotoxins (ITs) for the specific targeting and elimination of malignant cell populations. Unlike conventional ITs, hCFPs comprise a human/humanized target cell-specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfbbc4e5e389ebddccdb623b7818a98c
https://pubmed.ncbi.nlm.nih.gov/27110669
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8
Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo
Autor: Thomas Nachreiner, Tim H. Brümmendorf, Edgar Jost, Lea Schenke, Hanna Braun, Christian Cremer, Xiaojing Cong, Radoslav Mladenov, Rainer Fischer, Stefan Barth, Paolo Carloni
Publikováno v: Cancer immunology, immunotherapy : CII. 64(12)
Immunotoxins are fusion proteins that combine a targeting component such as an antibody fragment or ligand with a cytotoxic effector component that induces apoptosis in specific cell populations displaying the corresponding antigen or receptor. Human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab491dd3cc9cfefa0146ee48b16f0195
https://pubmed.ncbi.nlm.nih.gov/26472728
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9
Tuning the Redox Potentials of Dinuclear Tungsten Oxo Complexes [(Cp*W(4,4′-R,R-2,2′-bpy)(-O))2][PF6]2 Toward Photochemical Water Splitting
Autor: Christian Cremer, Peter Burger
Publikováno v: Chemistry - A European Journal. 9:3583-3596
A series of novel dinuclear tungsten(IV) oxo complexes with disubstituted 4,4'-R,R-2,2'-bipyridyl (R(2)bpy) ligands of the type [(Cp*W(R(2)bpy)(mu-O))(2)][PF(6)](2) (R=NMe(2), tBu, Me, H, Cl) was prepared by hydrolysis of the tungsten(IV) trichloro c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a153886d93018d617271023d1bd01682
https://doi.org/10.1002/chem.200204330
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10
Synthesis and crystal structure of the 16 e− cationic tungsten(IV) complex [WCp*(4,4′-Me2bipy)Cl2]+BPh4− †
Autor: Peter Burger, Christian Cremer
Publikováno v: Journal of the Chemical Society, Dalton Transactions. :1967-1974
A general synthetic route to electron rich half-sandwich tungsten(IV) complexes with a series of 4,4′-disubstituted 2,2′-bipyridyl (R2bipy) donor ligands of the type [WIVCp*(R2bipy)Cl3] has been elaborated. The crystal structure and conductivity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83ebd4d37b941026e41c29efeba954ab
https://doi.org/10.1039/a902743b
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