Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Christian Conrad"'
Autor:
Ulrike Taron, Martin Braun, Naveed Ishaque, Marcel Jentsch, Valentin Schneider-Lunitz, Sven Twardziok, Harald Wagener, Christian Conrad
Publikováno v:
F1000Research, Vol 13 (2024)
Biomedical research projects are becoming increasingly complex and require technological solutions that support all phases of the data lifecycle and application of the FAIR principles. At the Berlin Institute of Health (BIH), we have developed and es
Externí odkaz:
https://doaj.org/article/61441284d3eb46bd82e1cdc1e32a3572
Autor:
Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad, Oliver Strobel
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatar
Externí odkaz:
https://doaj.org/article/67e84cf093684d099e7a2f8d345931a2
Autor:
Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian D. S. Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L. Heppner, Roland Eils, Marcus A. Mall, J. Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J. Wareham, Christian Conrad, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Genetic factors have been found to be associated with severe COVID-19. Here, the authors integrated genomic, proteomic, and single-cell data to identify ELF5 as a candidate risk gene with a possible role in respiratory epithelial cells, which are tar
Externí odkaz:
https://doaj.org/article/7bddc4d6d42748edbe382377dc878d84
Autor:
Foo Wei Ten, Dongsheng Yuan, Nabil Jabareen, Yin Jun Phua, Roland Eils, Sören Lukassen, Christian Conrad
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Feature identification and manual inspection is currently still an integral part of biological data analysis in single-cell sequencing. Features such as expressed genes and open chromatin status are selectively studied in specific contexts, cell stat
Externí odkaz:
https://doaj.org/article/b02bbcd6ab174203b37dc2701d23b875
Autor:
Teresa G. Krieger, Solange Le Blanc, Julia Jabs, Foo Wei Ten, Naveed Ishaque, Katharina Jechow, Olivia Debnath, Carl-Stephan Leonhardt, Anamika Giri, Roland Eils, Oliver Strobel, Christian Conrad
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and ba
Externí odkaz:
https://doaj.org/article/f77b80eb08eb4c0a93db5169bb083e64
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Martina K. Zowada, Stephan M. Tirier, Sebastian M. Dieter, Teresa G. Krieger, Ava Oberlack, Robert Lorenz Chua, Mario Huerta, Foo Wei Ten, Karin Laaber, Jeongbin Park, Katharina Jechow, Torsten Müller, Mathias Kalxdorf, Mark Kriegsmann, Katharina Kriegsmann, Friederike Herbst, Jeroen Krijgsveld, Martin Schneider, Roland Eils, Hanno Glimm, Christian Conrad, Claudia R. Ball
Publikováno v:
Cancers, Vol 13, Iss 5, p 1097 (2021)
Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell RNA-sequencing of patient-derived CRC models to decipher distinct cell subpopulations based
Externí odkaz:
https://doaj.org/article/820796e1edaa45718ea43138095a1254
Autor:
Christian Conrad
Publikováno v:
Southwest Respiratory and Critical Care Chronicles, Vol 5, Iss 20 (2017)
Externí odkaz:
https://doaj.org/article/c58768c906634de9a0ed11fed1ffe772
Autor:
Christian Conrad
Publikováno v:
Southwest Respiratory and Critical Care Chronicles, Vol 5, Iss 19 (2017)
Externí odkaz:
https://doaj.org/article/dd19617048c64f87b88de7e5d55eb154
Publikováno v:
Applied Sciences, Vol 9, Iss 6, p 1068 (2019)
More than three decades ago, at Fraunhofer IZFP, research activities that were related to the application of micromagnetic methods for nondestructive testing (NDT) of the microstructure and the properties of ferrous materials commenced. Soon, it was
Externí odkaz:
https://doaj.org/article/dcfb24a6d9e6409fa6ddd40e0a70b052