Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christian Carbe"'
Publikováno v:
Cancer Research. 83:3063-3063
Triple negative breast cancer (TNBC) is frequently diagnosed in younger women and is prevalent in African American women. Most TNBCs are highly aggressive with early pattern of metastasis, and with limited treatment options and poor prognosis. Findin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a03da6712320391fe0d3950d427cc677
https://doi.org/10.1158/1538-7445.am2023-3063
https://doi.org/10.1158/1538-7445.am2023-3063
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd9320dee7766c95171bd447be3af16
https://doi.org/10.1096/fasebj.2022.36.s1.r5831
https://doi.org/10.1096/fasebj.2022.36.s1.r5831
Autor:
Christian Carbe, Maike Frye, Anne M. Moon, Srinivas Reddy Pallerla, Stefanie Ohlig, Yi Pan, Ruth Seelige, Jeffrey D. Esko, Ute Pickhinke, Kay Grobe, Sabine Kupich, Roger Lawrence, Xin Zhang
Publikováno v:
Matrix Biology. 35:253-265
Impaired heparan sulfate (HS) synthesis in vertebrate development causes complex malformations due to the functional disruption of multiple HS-binding growth factors and morphogens. Here, we report developmental heart defects in mice bearing a target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32232ae3e8d9e56007c3f636808e7aee
Publikováno v:
Journal of Biological Chemistry. 288:12130-12141
The advent of the ocular and nervous system in metazoan evolution coincides with the diversification of a single ancestral paired box (Pax) gene into Pax6, Pax6(5a), and Pax2. To investigate the role of these Pax genes in neural development, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2952fc5234fcf761a6cbf4190c0a702d
https://doi.org/10.1074/jbc.m112.436865
https://doi.org/10.1074/jbc.m112.436865
Autor:
Christian Carbe, Xin Zhang
Publikováno v:
Human Molecular Genetics. 20:1315-1323
Aphakia (lack of lens) is a rare human congenital disorder with its genetic etiology largely unknown. Even in model organisms, very few mutations are known to result in such a drastic ocular defect. In this study, we have shown that homozygous deleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7958b1c84d42fbc263448316b09d5ff9
https://doi.org/10.1093/hmg/ddr014
https://doi.org/10.1093/hmg/ddr014
Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development
Publikováno v:
Development. 137:1085-1093
Shp2/Ptpn11 tyrosine phosphatase is a general regulator of the RTK pathways. By genetic ablation, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, survival and differentiation. Shp2 deletion disrupted ERK sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629d33292b1910f0a23e8db39cfbfa4a
https://doi.org/10.1242/dev.042820
https://doi.org/10.1242/dev.042820
Autor:
Natalia A. Riobo, Jessica I. Gold, Walter J. Koch, Erhe Gao, Sankar Addya, Lan Cheng, Christian Carbe
During myocardial ischemia, upregulation of the hedgehog (Hh) pathway promotes neovascularization and increases cardiomyocyte survival. The canonical Hh pathway activates a transcriptional program through the Gli family of transcription factors by de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d9e868cdab0b38fd72bc70895e43a6
https://europepmc.org/articles/PMC4080174/
https://europepmc.org/articles/PMC4080174/
Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development
Glycosaminoglycans (GAGs) play a central role in embryonic development by regulating the movement and signaling of morphogens. We have previously demonstrated that GAGs are the co-receptors for Fgf10 signaling in the lacrimal gland epithelium, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c712885ec527f066ac0bbe9dbea006f
https://europepmc.org/articles/PMC3392702/
https://europepmc.org/articles/PMC3392702/
Publikováno v:
Developmental Biology. 356(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3deab8412698e33acc4d81c36da3b9
Publikováno v:
Developmental biology. 363(1)
Pax6 is an essential transcription factor for lens, lacrimal gland and pancreas development. Previous transgenic analyses have identified several Pax6 regulatory elements, but their functional significance and binding factors remain largely unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507de0f5ce4d038be8354eded38c2964
https://pubmed.ncbi.nlm.nih.gov/22240097
https://pubmed.ncbi.nlm.nih.gov/22240097