A HumanIn VitroModel That Mimics the Renal Proximal Tubule

Autor: Anna Gosiewska, Heike Walles, Johanna Schanz, Anke Hoppensack, Katja Schenke-Layland, Christian C. Kazanecki, David C. Colter

Publikováno v: Tissue Engineering Part C: Methods. 20:599-609

Human in vitro-manufactured tissue and organ models can serve as powerful enabling tools for the exploration of fundamental questions regarding cell, matrix, and developmental biology in addition to the study of drug delivery dynamics and kinetics. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150559d245ab39e7dbf1a11ccbb28ce0
https://doi.org/10.1089/ten.tec.2013.0446

Plasma Osteopontin Modulates Chronic Restraint Stress-Induced Thymus Atrophy by Regulating Stress Hormones: Inhibition by an Anti-Osteopontin Monoclonal Antibody

Autor: Yufang Shi, Yacov Ron, David T. Denhardt, Christian C. Kazanecki, Kathryn X. Wang

Publikováno v: The Journal of Immunology. 182:2485-2491

Osteopontin (OPN) is a cytokine implicated in mediating responses to certain stressors, including mechanical, oxidative, and cellular stress. However, the involvement of OPN in responding to other physical and psychological stress is largely unexplor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d1b656a6fd0fa514706d5d72af8125
https://doi.org/10.4049/jimmunol.0803023

Osteopontin-Deficient Bone Cells Are Defective in Their Ability to Produce NO in Response to Pulsatile Fluid Flow

Autor: E.H. Burger, Shuba Krishna, Christian C. Kazanecki, C.M. Semeins, David T. Denhardt, Jenneke Klein-Nulend

Publikováno v: Biochemical and Biophysical Research Communications. 288:448-453

Osteopontin (OPN) is a noncollagenous component of bone matrix. It mediates cell attachment and activates signal transduction pathways. In this work, bone cells, cultured from fragments of long bones derived from wild-type and OPN −/− (“knock-o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80965572c5f0972ef3072de36187275
https://doi.org/10.1006/bbrc.2001.5780

A FLUID FLOW RESPONSE DEFICIENCY OF OSTEOPONTIN KNOCK-OUT LONG BONE CELLS

Autor: David T. Denhardt, Larry W. Fisher, Christian C. Kazanecki, Esben S. Sørensen

Publikováno v: 3rd International Conference on Osteopontin and SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) Proteins, 2002.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bdaef0907f901264a93aed8e67c9f2f
https://doi.org/10.1100/tsw.2002.277

Cell-type specific post-translational modifications of mouse osteopontin are associated with different adhesive properties

Autor: David T. Denhardt, Brian Christensen, Esben S. Sørensen, Christian C. Kazanecki, Susan R. Rittling, Torben E. Petersen

Publikováno v: Aarhus University
Christensen, B, Kazanecki, C C, Petersen, T E, Rittling, S R, Denhardt, D T & Sørensen, E S 2007, ' Cell-type specific post-translational modifications of mouse osteopontin are associated with different adhesive properties ', Journal of Biological Chemistry, vol. 282, pp. 19463-19472 .

Osteopontin (OPN) is a highly modified integrin-binding protein found in all body fluids. Expression of OPN is strongly correlated with poor prognosis in many different human cancers, suggesting an important but poorly understood role for this protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8456aabc0ac032d486fd4274fe0eb116
https://pure.au.dk/portal/en/publications/celltype-specific-posttranslational-modifications-of-mouse-osteopontin-are-associated-with-different-adhesive-properties(1268f1a0-6de8-11dc-bee9-02004c4f4f50).html