Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Christian C, Felder"'
Autor:
Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The M4 muscarinic acetylcholine receptor (M4 mAChR) has emerged as a drug target of high therapeutic interest due to its expression in regions of the brain involved in the regulation of psychosis, cognition, and addiction. The mAChR agonist,
Externí odkaz:
https://doaj.org/article/7484d1906038449ebf83ab0a1980953a
Autor:
Scott A. Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A. J. Venkatakrishnan, Samuel Hertig, Peter J. Scammells, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Ron O. Dror
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Allosteric GPCR modulators can achieve exquisite subtype selectivity, but the underlying mechanism is unclear. Using molecular dynamics simulations, the authors here identify a previously undetected dynamic pocket in muscarinic GPCRs that is critical
Externí odkaz:
https://doaj.org/article/a0e90ef319f249dd8f9b3fd6b23a0233
Publikováno v:
Trends in Pharmacological Sciences. 43:1098-1112
Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia began in the 1990s when xanomeline, an M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63266f26f1cb0b097ede00179965f79c
https://doi.org/10.1016/j.tips.2022.09.006
https://doi.org/10.1016/j.tips.2022.09.006
Autor:
Jurgen Wess, Celine Valant, Andrew B. Tobin, David Thal, Roy D. Schwarz, Neil M. Nathanson, Ernst Mutschler, Fred Mitchelson, Chris Langmead, Günter Lambrecht, Heinz J. Kilbinger, Rudolf Hammer, Christian C. Felder, Frederick Ehlert, Richard M. Eglen, Arthur Christopoulos, R.A. John Challiss, Noel J. Buckley, David A. Brown, Sophie Bradley, Nigel J. M. Birdsall
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2393b817766271e25eebe9983a497ad3
https://doi.org/10.2218/gtopdb/f2/2023.1
https://doi.org/10.2218/gtopdb/f2/2023.1
Autor:
Ruth A. Ross, Roger G. Pertwee, Raphael Mechoulam, Ken Mackie, George Kunos, Allyn C. Howlett, Miles Herkenham, Peter Greasley, Christian C. Felder, Maurice R. Elphick, Vincenzo Di Marzo, William A. Devane, Ben F. Cravatt, Pierre Casellas, Guy Cabral, Heather Bradshaw, Tom I. Bonner, Francis Barth, Stephen P.H. Alexander, Mary Abood
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Cannabinoid Receptors [119]) are activated by endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d5489659fc23b87305e9aae2761f5b
https://doi.org/10.2218/gtopdb/f13/2023.1
https://doi.org/10.2218/gtopdb/f13/2023.1
Autor:
Jack K. McDonald, Emma T. van der Westhuizen, Vi Pham, Geoff Thompson, Christian C. Felder, Steven M. Paul, David M. Thal, Arthur Christopoulos, Celine Valant
Publikováno v:
ACS Chemical Neuroscience. 13:1206-1218
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0896bb8e581162bb30dc8d61f3362f1
https://doi.org/10.1021/acschemneuro.1c00827
https://doi.org/10.1021/acschemneuro.1c00827
Autor:
Alexander S. Powers, Vi Pham, Wessel A. C. Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W. Barnes, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Celine Valant, Ron O. Dror
Publikováno v:
Nature Chemical Biology.
A drug’s selectivity for target receptors is essential to its therapeutic utility, but achieving selectivity between similar receptors is challenging. The serendipitous discovery of ligands that stimulate target receptors more strongly than closely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd1a26cb8c19fe6e1b36ab5513e6e75
https://doi.org/10.1038/s41589-022-01247-5
https://doi.org/10.1038/s41589-022-01247-5
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188330 (2017)
Rodent genomic alignment sequences support a 2-exon model for muscarinic M4 receptor. Using this model a novel N-terminal extension was discovered in the human muscarinic acetylcholine M4 receptor. An open reading frame was discovered in the human, m
Externí odkaz:
https://doaj.org/article/1a80c16f89fc47e6acd5288c98a23616
Publikováno v:
The American journal of psychiatry. 179(9)
Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44238deab258d46533d3956a5ff2fbb8
https://pubmed.ncbi.nlm.nih.gov/35758639
https://pubmed.ncbi.nlm.nih.gov/35758639
Autor:
Alexander S. Powers, Vi Pham, Wessel A. C. Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W. Barnes, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Celine Valant, Ron O. Dror
Publikováno v:
Nature Chemical Biology. 19:529-529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc8514f2180841d085453224a9975a6
https://doi.org/10.1038/s41589-023-01297-3
https://doi.org/10.1038/s41589-023-01297-3