Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases

Autor: Ruchika Bhujbalrao, Krishna Gavvala, Reman Kumar Singh, Juhi Singh, Christian Boudier, Sutapa Chakrabarti, G. Naresh Patwari, Yves Mély, Ruchi Anand

Antibiotic resistance via epigenetic methylation of ribosomal RNA is one of the most prevalent strategies adopted by multidrug resistant pathogens. The erythromycin-resistance methyltransferase (Erm) methylates rRNA at the conserved A2058 position an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e65f8218ec34419844e0b8646c1337
https://refubium.fu-berlin.de/handle/fub188/38299

(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity

Autor: Nicolas Humbert, Maurizio Botta, Federica Poggialini, Eleonore Real, Manuel Pires, Christian Boudier, Vitaly I. Kalchenko, Yves Mély, Alessia Giannini, Maurizio Zazzi, Carole Seguin-Devaux, Sarah Cianférani, S. O. Cherenok, Kamal Kant Sharma, Mattia Mori, Francesco Saladini, Thomas Botzanowski, Lesia Kovalenko, Olga A. Zaporozhets

Publikováno v: ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2020, ⟨10.1021/acsinfecdis.9b00290⟩

International audience; The nucleocapsid protein (NC) is a highly conserved protein that plays key roles in HIV-1 replication through its nucleic acid chaperone properties mediated by its two zinc fingers and basic residues. NC is a promising target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a6105171b7fd6177f9a44506ea2322
https://hal.archives-ouvertes.fr/hal-02493003

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds

Autor: Stefano Roelens, Mattia Mori, Christian Boudier, Yves Mély, Carole Seguin-Devaux, Cristina Nativi, Nicolas Humbert, Oscar Francesconi, Stefano Ciaco, Eleonore Real

Publikováno v: ACS Med Chem Lett

[Image: see text] The HIV-1 nucleocapsid protein 7 (NC) is a potential target for effective antiretroviral therapy due to its central role in virus replication, mainly linked to nucleic acid (NA) chaperone activity, and low susceptibility to drug res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b60097268fa454d358f241d76e53f
http://hdl.handle.net/11365/1120396

Environmentally Sensitive Fluorescent Nucleoside Analogues for Surveying Dynamic Interconversions of Nucleic Acid Structures

Autor: Lyes Zaghzi, Olga A. Zaporozhets, Viktoriia Y. Postupalenko, Yves Mély, Nicolas Barthes, Yitzhak Tor, Marianna Sholokh, Rajhans Sharma, Christian Boudier, Natalia Grytsyk, Alain Burger, Benoît Y. Michel, Dmytro Dziuba

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(52)

Nucleic acids are characterized by a variety of dynamically interconverting structures that play a major role in transcriptional and translational regulation as well as recombination and repair. To monitor these interconversions, Forster resonance en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2faceda82bb15d7ede3b125144893be
https://pubmed.ncbi.nlm.nih.gov/29989220

Role of the Nucleocapsid Domain in HIV-1 Gag Oligomerization and Trafficking to the Plasma Membrane: A Fluorescence Lifetime Imaging Microscopy Investigation

Autor: Salah Edin El Meshri, Hugues de Rocquigny, Jean-Luc Darlix, Ludovic Richert, Yves Mély, Christian Boudier, Pascal Didier, Julien Godet, Denis Dujardin

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2015, 427, pp.1480-1494
Journal of Molecular Biology, Elsevier, 2015, 427 (6 Pt B), pp.1480-1494. ⟨10.1016/j.jmb.2015.01.015⟩
Journal of Molecular Biology, 2015, 427 (6 Pt B), pp.1480-1494. ⟨10.1016/j.jmb.2015.01.015⟩

International audience; The Pr55 Gag of human immunodeficiency virus type 1 orchestrates viral particle assembly in producer cells, which requires the genomic RNA and a lipid membrane as scaffolding platforms. The nucleocapsid (NC) domain with its tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e464b52a91a5705e87ef4f1801001e9
https://doi.org/10.1016/j.jmb.2015.01.015