Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christian Bisang"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2850-2858
Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efeeebb170d6ec6e36bda33e294a435
https://doi.org/10.1016/j.bmc.2017.08.006
https://doi.org/10.1016/j.bmc.2017.08.006
Autor:
John A. Robinson, Christian Bisang, Steven J. Demarco, Kerstin Moehle, Francesca Bernardini, Daniel Obrecht, Frank Gombert
Publikováno v:
Current Medicinal Chemistry. 16:42-65
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance. There is also an urgent ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f83b16b56831a1d6e774ffb8f130237
https://doi.org/10.2174/092986709787002844
https://doi.org/10.2174/092986709787002844
Autor:
Peter F. Leadlay, Paul F. Long, Nicholas J. Dunster, Hamish A. I. McArthur, Marko Oliynyk, Carmen Méndez, Christian Bisang, Jesus Cortes, Ellen L. McCormick, José A. Salas, Christopher J. Wilkinson, James Staunton
Publikováno v:
Molecular Microbiology. 43:1215-1225
Chain initiation on many modular polyketide synthases is mediated by acyl transfer from the CoA ester of a dicarboxylic acid, followed by decarboxylation in situ by KSQ, a ketosynthase-like decarboxylase domain. Consistent with this, the acyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa4bf6ca474ba793fe01407f71b1c84
https://doi.org/10.1046/j.1365-2958.2002.02815.x
https://doi.org/10.1046/j.1365-2958.2002.02815.x
Autor:
Ernst Freund, Fabienne Emery, Hugues Matile, Christian Bauch, Christian Bisang, Gerd Pluschke, John A. Robinson, Luyong Jiang
Publikováno v:
Journal of the American Chemical Society. 120:7439-7449
The immunodominant central portion of the circumsporozoite (CS) surface protein of the malaria parasite Plasmodium falciparum contains a tetrapeptide motif, Asn-Pro-Asn-Ala (NPNA), tandemly repeated almost 40 times. The three-dimensional structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd55acb8316cf895387b8b156a9be4c1
https://doi.org/10.1021/ja980444j
https://doi.org/10.1021/ja980444j
Publikováno v:
Helvetica Chimica Acta. 79:1825-1842
We explore here an approach to mimic the structures and biological functions of protein loops in small synthetic molecules, by grafting the loop of interest onto an organic template comprising a bicyclic diketopiperazine, prepared by the formal coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f510b3c2601673eaeaf3a3db6f10ead
https://doi.org/10.1002/hlca.19960790708
https://doi.org/10.1002/hlca.19960790708
Autor:
Christian Bisang, Christoph K. Weber, Janice Inglis, Ilian Jelesarov, Celia A. Schiffer, Wilfred F. van Gunsteren, Hans Rudolf Bosshard, John A. Robinson
Publikováno v:
Journal of the American Chemical Society. 117:7904-7915
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cba4bbbb287dc0936c41ad4c061837
https://doi.org/10.1021/ja00135a008
https://doi.org/10.1021/ja00135a008
Publikováno v:
ChemInform. 28
A trifunctional template 1 is synthesized from trans-4-hydroxy-L-proline and L-aspartic acid, immobilized on a solid-support, and used for the solid-phase synthesis of a cyclic conformationally restrained hexapeptide loop mimetic containing the motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::283f3d612587cb0393bb7ac04be03347
https://doi.org/10.1002/chin.199708198
https://doi.org/10.1002/chin.199708198
Publikováno v:
ChemInform. 28
We explore here an approach to mimic the structures and biological functions of protein loops in small synthetic molecules, by grafting the loop of interest onto an organic template comprising a bicyclic diketopiperazine, prepared by the formal coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca97dccc6dc539b2552a742cfa1e728
https://doi.org/10.1002/chin.199705230
https://doi.org/10.1002/chin.199705230
Autor:
C Ludin, Christian Bisang, O Sellier-Kessler, E Chevalier, Kerstin Moehle, J Zumbrunn, S De Marco, F Jung, Daniel Obrecht, Frank Otto Gombert, H Henze, G Lemercier
Publikováno v:
D30. THE ROLE OF INFLAMMATION IN CHRONIC INTERSTITIAL LUNG DISEASE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee164bcfafa642f61ec817e2ad3b6b8f
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5652
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5652
Autor:
Michelle A. Jones, J. Staunton, H. A. I. Mcarthur, Christian B. W. Stark, Elizabeth J. Frost, J. B. Lester, Jesus Cortes, Christopher J. Wilkinson, Ellen L. McCormick, Peter F. Leadlay, Christian Bisang, Steven G. Kendrew, Zoë A. Hughes-Thomas, Markiyan Oliynyk, Z. Oliynyk, Paul F. Long
Publikováno v:
Journal of industrial microbiologybiotechnology. 27(6)
The biosynthesis of complex reduced polyketides is catalysed in actinomycetes by large multifunctional enzymes, the modular Type I polyketide synthases (PKSs). Most of our current knowledge of such systems stems from the study of a restricted number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaba8f8ac0625b0632af8f9cec812be
https://pubmed.ncbi.nlm.nih.gov/11774001
https://pubmed.ncbi.nlm.nih.gov/11774001