Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Christian Billard"'
Autor:
Faten Merhi, Ruoping Tang, Marion Piedfer, Julie Mathieu, Isabelle Bombarda, Murhaf Zaher, Jean-Pierre Kolb, Christian Billard, Brigitte Bauvois
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25963 (2011)
BACKGROUND: The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and
Externí odkaz:
https://doaj.org/article/b330629cdc8643bbbf6441442d95ea50
Publikováno v:
Blood Reviews. 29:345-350
A typical feature of chronic lymphocytic leukemia (CLL) is the impaired ability of the leukemic cells to execute their apoptotic suicide program. Various strategies have been developed to restore apoptosis in CLL cells ex vivo. This article reviews t
Autor:
Christian Billard
Publikováno v:
Lymphoma and Chronic Lymphocytic Leukemias. 5:11-15
Despite significant advances in chemoimmunotherapy, chronic lymphocytic leukemia (CLL) is still incurable. This has prompted the development of new drugs and therapeutic strategies that include reactivating the impaired apoptosis (programed cell deat
Autor:
Christian Billard
Publikováno v:
International Journal of Hematologic Oncology. 3:233-241
SUMMARY Deficiency in the apoptotic program is one of the hallmarks of chronic lymphocytic leukemia. Defective apoptosis mainly results from the constitutive activation of survival pathways, which leads to the transcription and overexpression of anti
Autor:
Christian Billard
Publikováno v:
Oncotarget
// Christian Billard 1,2 1 INSERM U 872, Centre de Recherche des Cordeliers, Equipe 18, Paris, France 2 Universite Pierre et Marie Curie (UMRS 872), Paris, France. Correspondence: Christian Billard, email: // Keywords : CLL; impaired cell death progr
Autor:
Christian Billard
Publikováno v:
Molecular Cancer Therapeutics. 12:1691-1700
Targeting apoptosis is an attractive approach in cancer therapy. The BH3-only proteins of the BCL-2 family (having only the BCL-2 homology domain BH3) can trigger apoptosis by binding to the prosurvival members of this family and neutralizing their f
Autor:
Christian Billard
Publikováno v:
Molecular Cancer Research. 10:673-676
Despite real advances made in chemoimmunotherapy, chronic lymphocytic leukemia (CLL) is still an incurable disease. New therapeutic strategies based on the restoration of the cell death program seemed relevant. Some members of the Bcl-2 family are cr
Autor:
Juliette Nguyen, Ruoping Tang, Brigitte Bauvois, Marion Piedfer, Daniel Dauzonne, Christian Billard
Publikováno v:
The FASEB Journal
The transmembrane metalloprotease aminopeptidase‐N (APN)/CD13 is overexpressed in various solid and hematological malignancies in humans, including acute myeloid leukemia (AML) and is thought to influence tumor progression. Here, we investigated th
Publikováno v:
The Open Leukemia Journal. 3:24-33
CLL cells are resistant in vivo to apoptosis, in part, through the autocrine action of the survival factors BAFF and APRIL. We show here, by flow cytometry, that stimulation of Toll-like receptor-7 (TLR-7) with imidazoquinolines induces increases in
Publikováno v:
Leukemia & Lymphoma. 48:1587-1599
We showed previously that hyperforin (HF), a natural phloroglucinol, stimulated apoptosis in B cell chronic lymphocytic leukaemia cells (CLL) and displayed anti-angiogenic properties. In the present work, we investigated the effects of hyperforin on