Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Christian Betzel"'
Autor:
Andreas Prester, Markus Perbandt, Marina Galchenkova, Dominik Oberthuer, Nadine Werner, Alessandra Henkel, Julia Maracke, Oleksandr Yefanov, Johanna Hakanpää, Guillaume Pompidor, Jan Meyer, Henry Chapman, Martin Aepfelbacher, Winfried Hinrichs, Holger Rohde, Christian Betzel
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The emergence and spread of antibiotic resistance represent a growing threat to public health. Of particular concern is the appearance of β-lactamases, which are capable to hydrolyze and inactivate the most important class of antibiotics, t
Externí odkaz:
https://doaj.org/article/8df6755d143d4e47afcdc923e679304e
Autor:
Ani Harutyunyan, Liana Gabrielyan, Anush Aghajanyan, Susanna Gevorgyan, Robin Schubert, Christian Betzel, Wojciech Kujawski, Lilit Gabrielyan
Publikováno v:
ACS Omega, Vol 9, Iss 27, Pp 29410-29421 (2024)
Externí odkaz:
https://doaj.org/article/e292748fc4234eea8b343581b24e508b
Autor:
Patrick Y. A. Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker, Chan Kim, Christina Schmidt, Faisal H. M. Koua, Alexandra Tolstikova, Wiebke Ewert, Gisel Esperanza Peña Murillo, Grant Mills, Henry Kirkwood, Hévila Brognaro, Huijong Han, Jayanath Koliyadu, Joachim Schulz, Johan Bielecki, Julia Lieske, Julia Maracke, Juraj Knoska, Kristina Lorenzen, Lea Brings, Marcin Sikorski, Marco Kloos, Mohammad Vakili, Patrik Vagovic, Philipp Middendorf, Raphael de Wijn, Richard Bean, Romain Letrun, Seonghyun Han, Sven Falke, Tian Geng, Tokushi Sato, Vasundara Srinivasan, Yoonhee Kim, Oleksandr M. Yefanov, Luca Gelisio, Tobias Beck, Andrew S. Doré, Adrian P. Mancuso, Christian Betzel, Saša Bajt, Lars Redecke, Henry N. Chapman, Alke Meents, Dušan Turk, Winfried Hinrichs, Thomas J. Lane
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key drug target. Mpro is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. This suggests the system has evolved to survive pe
Externí odkaz:
https://doaj.org/article/7a737b71ae764265a7f11a3df650ea0b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by
Externí odkaz:
https://doaj.org/article/1dc8df3793c247a7821530fc163f0574
Autor:
Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we s
Externí odkaz:
https://doaj.org/article/959ee7d783844cc0965882267049dc4f
Autor:
Prabhu Rajaiah Prince, Janine Hochmair, Hévila Brognaro, Susanna Gevorgyan, Maximilian Franck, Robin Schubert, Kristina Lorenzen, Selin Yazici, Eckhard Mandelkow, Susanne Wegmann, Christian Betzel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated Tau is the main component of neurofibrillary tangles observed in Alzheimer’s disease. In vitro, Tau aggregation can be triggered by polyanionic c
Externí odkaz:
https://doaj.org/article/3a8096f753d74d81b89c1098d73793e0
Autor:
Kara A Zielinski, Andreas Prester, Hina Andaleeb, Soi Bui, Oleksandr Yefanov, Lucrezia Catapano, Alessandra Henkel, Max O. Wiedorn, Olga Lorbeer, Eva Crosas, Jan Meyer, Valerio Mariani, Martin Domaracky, Thomas A. White, Holger Fleckenstein, Iosifina Sarrou, Nadine Werner, Christian Betzel, Holger Rohde, Martin Aepfelbacher, Henry N. Chapman, Markus Perbandt, Roberto A. Steiner, Dominik Oberthuer
Publikováno v:
IUCrJ, Vol 9, Iss 6, Pp 778-791 (2022)
Serial crystallography at conventional synchrotron light sources (SSX) offers the possibility to routinely collect data at room temperature using micrometre-sized crystals of biological macromolecules. However, SSX data collection is not yet as routi
Externí odkaz:
https://doaj.org/article/1a539044df7442e893cbada6b50b1d5b
Autor:
Susanna Gevorgyan, Robin Schubert, Sven Falke, Kristina Lorenzen, Karen Trchounian, Christian Betzel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In recent years silver nanoparticles (Ag NPs) gained increased and widespread applications in various fields of industry, technology, and medicine. This study describes the green synthesis of silver nanoparticles (Ag NPs) applying a low-mole
Externí odkaz:
https://doaj.org/article/e77b710f2cd0484588ef69ebe168c274
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Markus Perbandt, Nadine Werner, Andreas Prester, Holger Rohde, Martin Aepfelbacher, Winfried Hinrichs, Christian Betzel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract β-lactamases are a major cause of rapidly emerging and spreading antibiotic resistance. Currently β-lactamase inhibitors (BLIs) in clinical use act only on Ambler Class A, C and some class D lactamases. The urgent need to identify new BLIs
Externí odkaz:
https://doaj.org/article/ca5190fa59cc4f238b62aa8a7960acb0